The role of the tissue renin-angiotensin-aldosterone system in the development of metabolic syndrome, diabetes mellitus and itsvascular complications
Renin-angiotensin-aldosterone system (RAAS) is a major system of the human body playing a key role in the regulation of most physiological andpathological conditions, such as vascular tone, AD level, myocardial and vascular wall remodeling, development of atherosclerosis, glomerulosclerosis,and othe...
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Endocrinology Research Centre
2010
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oai:doaj.org-article:f050afbe849841618793e235b48c940b2021-11-14T09:00:15ZThe role of the tissue renin-angiotensin-aldosterone system in the development of metabolic syndrome, diabetes mellitus and itsvascular complications2072-03512072-037810.14341/2072-0351-5481https://doaj.org/article/f050afbe849841618793e235b48c940b2010-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5481https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Renin-angiotensin-aldosterone system (RAAS) is a major system of the human body playing a key role in the regulation of most physiological andpathological conditions, such as vascular tone, AD level, myocardial and vascular wall remodeling, development of atherosclerosis, glomerulosclerosis,and other pathologies. The discovery of local (tissue) RAAS in the late XX century gave evidence of direct synthesis of all components of this system,from renin to aldosterone, in target tissues and organs. Activation of tissue RAAS was shown to play a leading role in the evolvement of diabetic complicationsincluding cardiovascular diseases, diabetic nephropathy (DN), and retinopathy. Recent studies revealed the presence of RAAS componentsin fat and pancreas. This system is involved in the development of visceral obesity, pre-diabetes, and Type 2 diabetes. These findings are confirmedby a reduced risk of CDM2 in subjects receiving long-term therapy with RAAS blockers.Marina Vladimirovna ShestakovaEndocrinology Research Centrearticlerenin-angiotensin-aldosterone systemvisceral obesitymetabolic syndromediabetes mellitusdiabetic nephropathydiabetic retinopathyNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 13, Iss 3, Pp 14-19 (2010) |
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DOAJ |
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DOAJ |
| language |
EN RU |
| topic |
renin-angiotensin-aldosterone system visceral obesity metabolic syndrome diabetes mellitus diabetic nephropathy diabetic retinopathy Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
renin-angiotensin-aldosterone system visceral obesity metabolic syndrome diabetes mellitus diabetic nephropathy diabetic retinopathy Nutritional diseases. Deficiency diseases RC620-627 Marina Vladimirovna Shestakova The role of the tissue renin-angiotensin-aldosterone system in the development of metabolic syndrome, diabetes mellitus and itsvascular complications |
| description |
Renin-angiotensin-aldosterone system (RAAS) is a major system of the human body playing a key role in the regulation of most physiological andpathological conditions, such as vascular tone, AD level, myocardial and vascular wall remodeling, development of atherosclerosis, glomerulosclerosis,and other pathologies. The discovery of local (tissue) RAAS in the late XX century gave evidence of direct synthesis of all components of this system,from renin to aldosterone, in target tissues and organs. Activation of tissue RAAS was shown to play a leading role in the evolvement of diabetic complicationsincluding cardiovascular diseases, diabetic nephropathy (DN), and retinopathy. Recent studies revealed the presence of RAAS componentsin fat and pancreas. This system is involved in the development of visceral obesity, pre-diabetes, and Type 2 diabetes. These findings are confirmedby a reduced risk of CDM2 in subjects receiving long-term therapy with RAAS blockers. |
| format |
article |
| author |
Marina Vladimirovna Shestakova |
| author_facet |
Marina Vladimirovna Shestakova |
| author_sort |
Marina Vladimirovna Shestakova |
| title |
The role of the tissue renin-angiotensin-aldosterone system in the development of metabolic syndrome, diabetes mellitus and itsvascular complications |
| title_short |
The role of the tissue renin-angiotensin-aldosterone system in the development of metabolic syndrome, diabetes mellitus and itsvascular complications |
| title_full |
The role of the tissue renin-angiotensin-aldosterone system in the development of metabolic syndrome, diabetes mellitus and itsvascular complications |
| title_fullStr |
The role of the tissue renin-angiotensin-aldosterone system in the development of metabolic syndrome, diabetes mellitus and itsvascular complications |
| title_full_unstemmed |
The role of the tissue renin-angiotensin-aldosterone system in the development of metabolic syndrome, diabetes mellitus and itsvascular complications |
| title_sort |
role of the tissue renin-angiotensin-aldosterone system in the development of metabolic syndrome, diabetes mellitus and itsvascular complications |
| publisher |
Endocrinology Research Centre |
| publishDate |
2010 |
| url |
https://doaj.org/article/f050afbe849841618793e235b48c940b |
| work_keys_str_mv |
AT marinavladimirovnashestakova theroleofthetissuereninangiotensinaldosteronesysteminthedevelopmentofmetabolicsyndromediabetesmellitusanditsvascularcomplications AT marinavladimirovnashestakova roleofthetissuereninangiotensinaldosteronesysteminthedevelopmentofmetabolicsyndromediabetesmellitusanditsvascularcomplications |
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