Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Allelic losses occurring in cancer cells have been suggested as potential targets for therapy. Here, the authors show how recurring loss of heterozygosity of a drug metabolic gene in colorectal cancers can be exploited using a low molecular weight compound.

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Autores principales:	Veronica Rendo, Ivaylo Stoimenov, André Mateus, Elin Sjöberg, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Adrian Ng, Casey OʼBrien, Marios Giannakis, Per Artursson, Peter Nygren, Ian Cheong, Tobias Sjöblom
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f0524ece03f240dd980cb46a0462a392
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spelling	oai:doaj.org-article:f0524ece03f240dd980cb46a0462a3922021-12-02T14:40:29ZExploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy10.1038/s41467-020-15111-42041-1723https://doaj.org/article/f0524ece03f240dd980cb46a0462a3922020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15111-4https://doaj.org/toc/2041-1723Allelic losses occurring in cancer cells have been suggested as potential targets for therapy. Here, the authors show how recurring loss of heterozygosity of a drug metabolic gene in colorectal cancers can be exploited using a low molecular weight compound.Veronica RendoIvaylo StoimenovAndré MateusElin SjöbergRichard SvenssonAnna-Lena GustavssonLars JohanssonAdrian NgCasey OʼBrienMarios GiannakisPer ArturssonPeter NygrenIan CheongTobias SjöblomNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Veronica Rendo Ivaylo Stoimenov André Mateus Elin Sjöberg Richard Svensson Anna-Lena Gustavsson Lars Johansson Adrian Ng Casey OʼBrien Marios Giannakis Per Artursson Peter Nygren Ian Cheong Tobias Sjöblom Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
description	Allelic losses occurring in cancer cells have been suggested as potential targets for therapy. Here, the authors show how recurring loss of heterozygosity of a drug metabolic gene in colorectal cancers can be exploited using a low molecular weight compound.
format	article
author	Veronica Rendo Ivaylo Stoimenov André Mateus Elin Sjöberg Richard Svensson Anna-Lena Gustavsson Lars Johansson Adrian Ng Casey OʼBrien Marios Giannakis Per Artursson Peter Nygren Ian Cheong Tobias Sjöblom
author_facet	Veronica Rendo Ivaylo Stoimenov André Mateus Elin Sjöberg Richard Svensson Anna-Lena Gustavsson Lars Johansson Adrian Ng Casey OʼBrien Marios Giannakis Per Artursson Peter Nygren Ian Cheong Tobias Sjöblom
author_sort	Veronica Rendo
title	Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
title_short	Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
title_full	Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
title_fullStr	Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
title_full_unstemmed	Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
title_sort	exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f0524ece03f240dd980cb46a0462a392
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Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

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