Differential Expression Profiles and Functional Prediction of circRNAs in Necrotizing Enterocolitis

Circular RNAs (circRNAs), a novel type of noncoding RNAs, have been demonstrated to behave as microRNA (miRNA) sponges to exert their effects during pathological processes of diseases. However, the roles of circRNAs have not been explored in necrotizing enterocolitis (NEC). This study sought to iden...

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Autores principales:	Ya Pan, Wenjuan Chen, Xiangyun Yan, Boshi Yu, Shuwen Yao, Xiaohui Chen, Shuping Han
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/f0534086e38f4e5f951196e405505b3d
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spelling	oai:doaj.org-article:f0534086e38f4e5f951196e405505b3d2021-11-15T01:19:30ZDifferential Expression Profiles and Functional Prediction of circRNAs in Necrotizing Enterocolitis2314-614110.1155/2021/9862066https://doaj.org/article/f0534086e38f4e5f951196e405505b3d2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9862066https://doaj.org/toc/2314-6141Circular RNAs (circRNAs), a novel type of noncoding RNAs, have been demonstrated to behave as microRNA (miRNA) sponges to exert their effects during pathological processes of diseases. However, the roles of circRNAs have not been explored in necrotizing enterocolitis (NEC). This study sought to identify differentially expressed circRNAs and predict their potential biological functions in NEC. circRNA expression profiles in terminal ileum from newborn rats with NEC and normal controls were explored using next-generation sequencing. In the NEC group, 53 circRNAs were significantly differentially expressed, including 9 upregulated and 44 downregulated. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were conducted, and circRNA-miRNA interaction networks were generated to predict the potential roles of circRNAs in NEC progression. Further investigation revealed that most circRNAs include miRNA binding sites and that some are implicated in NEC development. In conclusion, this study’s findings demonstrate that differentially expressed circRNAs are involved in NEC development via their interactions with miRNAs, making them prospective targets for NEC diagnosis and treatment.Ya PanWenjuan ChenXiangyun YanBoshi YuShuwen YaoXiaohui ChenShuping HanHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Ya Pan Wenjuan Chen Xiangyun Yan Boshi Yu Shuwen Yao Xiaohui Chen Shuping Han Differential Expression Profiles and Functional Prediction of circRNAs in Necrotizing Enterocolitis
description	Circular RNAs (circRNAs), a novel type of noncoding RNAs, have been demonstrated to behave as microRNA (miRNA) sponges to exert their effects during pathological processes of diseases. However, the roles of circRNAs have not been explored in necrotizing enterocolitis (NEC). This study sought to identify differentially expressed circRNAs and predict their potential biological functions in NEC. circRNA expression profiles in terminal ileum from newborn rats with NEC and normal controls were explored using next-generation sequencing. In the NEC group, 53 circRNAs were significantly differentially expressed, including 9 upregulated and 44 downregulated. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were conducted, and circRNA-miRNA interaction networks were generated to predict the potential roles of circRNAs in NEC progression. Further investigation revealed that most circRNAs include miRNA binding sites and that some are implicated in NEC development. In conclusion, this study’s findings demonstrate that differentially expressed circRNAs are involved in NEC development via their interactions with miRNAs, making them prospective targets for NEC diagnosis and treatment.
format	article
author	Ya Pan Wenjuan Chen Xiangyun Yan Boshi Yu Shuwen Yao Xiaohui Chen Shuping Han
author_facet	Ya Pan Wenjuan Chen Xiangyun Yan Boshi Yu Shuwen Yao Xiaohui Chen Shuping Han
author_sort	Ya Pan
title	Differential Expression Profiles and Functional Prediction of circRNAs in Necrotizing Enterocolitis
title_short	Differential Expression Profiles and Functional Prediction of circRNAs in Necrotizing Enterocolitis
title_full	Differential Expression Profiles and Functional Prediction of circRNAs in Necrotizing Enterocolitis
title_fullStr	Differential Expression Profiles and Functional Prediction of circRNAs in Necrotizing Enterocolitis
title_full_unstemmed	Differential Expression Profiles and Functional Prediction of circRNAs in Necrotizing Enterocolitis
title_sort	differential expression profiles and functional prediction of circrnas in necrotizing enterocolitis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/f0534086e38f4e5f951196e405505b3d
work_keys_str_mv	AT yapan differentialexpressionprofilesandfunctionalpredictionofcircrnasinnecrotizingenterocolitis AT wenjuanchen differentialexpressionprofilesandfunctionalpredictionofcircrnasinnecrotizingenterocolitis AT xiangyunyan differentialexpressionprofilesandfunctionalpredictionofcircrnasinnecrotizingenterocolitis AT boshiyu differentialexpressionprofilesandfunctionalpredictionofcircrnasinnecrotizingenterocolitis AT shuwenyao differentialexpressionprofilesandfunctionalpredictionofcircrnasinnecrotizingenterocolitis AT xiaohuichen differentialexpressionprofilesandfunctionalpredictionofcircrnasinnecrotizingenterocolitis AT shupinghan differentialexpressionprofilesandfunctionalpredictionofcircrnasinnecrotizingenterocolitis
_version_	1718428958869946368

Differential Expression Profiles and Functional Prediction of circRNAs in Necrotizing Enterocolitis

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