Octacosanol restores stress-affected sleep in mice by alleviating stress

Abstract Octacosanol, a component of various food materials, possesses prominent biological activities and functions. It fights against cellular stress by increasing glutathione level and thus scavenging oxygen reactive species. However, its anti-stress activity and role in sleep induction remained...

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Autores principales:	Mahesh K. Kaushik, Kosuke Aritake, Atsuko Takeuchi, Masashi Yanagisawa, Yoshihiro Urade
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f05c1581e20c4d48ae0ce5c4dd8d2f7a
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spelling	oai:doaj.org-article:f05c1581e20c4d48ae0ce5c4dd8d2f7a2021-12-02T11:40:43ZOctacosanol restores stress-affected sleep in mice by alleviating stress10.1038/s41598-017-08874-22045-2322https://doaj.org/article/f05c1581e20c4d48ae0ce5c4dd8d2f7a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08874-2https://doaj.org/toc/2045-2322Abstract Octacosanol, a component of various food materials, possesses prominent biological activities and functions. It fights against cellular stress by increasing glutathione level and thus scavenging oxygen reactive species. However, its anti-stress activity and role in sleep induction remained elusive. We hypothesize that octacosanol can restore stress-affected sleep by mitigating stress. Cage change strategy was used to induce mild stress and sleep disturbance in mice, and effects of octacosanol administration on amount of sleep and stress were investigated. Results showed that octacosanol did not change rapid eye movement (REM) or non-REM (NREM) sleep compared to vehicle in normal mice. However, in cage change experiment, octacosanol induces significant increase in NREM sleep at doses of 100 and 200 mg/kg (75.7 ± 14.9 and 82.7 ± 9.3 min/5 h) compared to vehicle (21.2 ± 5.1 min/5 h), and decreased sleep latency. Octacosanol induced sleep by increasing number of sleep episodes and decreasing wake episode duration. Plasma corticosterone levels were significantly reduced after octacosanol (200 mg/kg) administration, suggesting a decrease in stress level. Octacosanol-induced changes in sleep-wake parameters in stressed-mice were comparable to the values in normal mice. Together, these data clearly showed that, though octacosanol does not alter normal sleep, it clearly alleviates stress and restore stress-affected sleep.Mahesh K. KaushikKosuke AritakeAtsuko TakeuchiMasashi YanagisawaYoshihiro UradeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mahesh K. Kaushik Kosuke Aritake Atsuko Takeuchi Masashi Yanagisawa Yoshihiro Urade Octacosanol restores stress-affected sleep in mice by alleviating stress
description	Abstract Octacosanol, a component of various food materials, possesses prominent biological activities and functions. It fights against cellular stress by increasing glutathione level and thus scavenging oxygen reactive species. However, its anti-stress activity and role in sleep induction remained elusive. We hypothesize that octacosanol can restore stress-affected sleep by mitigating stress. Cage change strategy was used to induce mild stress and sleep disturbance in mice, and effects of octacosanol administration on amount of sleep and stress were investigated. Results showed that octacosanol did not change rapid eye movement (REM) or non-REM (NREM) sleep compared to vehicle in normal mice. However, in cage change experiment, octacosanol induces significant increase in NREM sleep at doses of 100 and 200 mg/kg (75.7 ± 14.9 and 82.7 ± 9.3 min/5 h) compared to vehicle (21.2 ± 5.1 min/5 h), and decreased sleep latency. Octacosanol induced sleep by increasing number of sleep episodes and decreasing wake episode duration. Plasma corticosterone levels were significantly reduced after octacosanol (200 mg/kg) administration, suggesting a decrease in stress level. Octacosanol-induced changes in sleep-wake parameters in stressed-mice were comparable to the values in normal mice. Together, these data clearly showed that, though octacosanol does not alter normal sleep, it clearly alleviates stress and restore stress-affected sleep.
format	article
author	Mahesh K. Kaushik Kosuke Aritake Atsuko Takeuchi Masashi Yanagisawa Yoshihiro Urade
author_facet	Mahesh K. Kaushik Kosuke Aritake Atsuko Takeuchi Masashi Yanagisawa Yoshihiro Urade
author_sort	Mahesh K. Kaushik
title	Octacosanol restores stress-affected sleep in mice by alleviating stress
title_short	Octacosanol restores stress-affected sleep in mice by alleviating stress
title_full	Octacosanol restores stress-affected sleep in mice by alleviating stress
title_fullStr	Octacosanol restores stress-affected sleep in mice by alleviating stress
title_full_unstemmed	Octacosanol restores stress-affected sleep in mice by alleviating stress
title_sort	octacosanol restores stress-affected sleep in mice by alleviating stress
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f05c1581e20c4d48ae0ce5c4dd8d2f7a
work_keys_str_mv	AT maheshkkaushik octacosanolrestoresstressaffectedsleepinmicebyalleviatingstress AT kosukearitake octacosanolrestoresstressaffectedsleepinmicebyalleviatingstress AT atsukotakeuchi octacosanolrestoresstressaffectedsleepinmicebyalleviatingstress AT masashiyanagisawa octacosanolrestoresstressaffectedsleepinmicebyalleviatingstress AT yoshihirourade octacosanolrestoresstressaffectedsleepinmicebyalleviatingstress
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Octacosanol restores stress-affected sleep in mice by alleviating stress

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