ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression

T-cell function impairment is one of the major determinants of tumour immune evasion. Here, the authors show that the hostile conditions in the tumour microenvironment lead to C/EBP homologous-protein upregulation in T cells via ER stress, resulting in repression of T-bet and consequent inhibition o...

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Autores principales:	Yu Cao, Jimena Trillo-Tinoco, Rosa A. Sierra, Carmen Anadon, Wenjie Dai, Eslam Mohamed, Ling Cen, Tara L. Costich, Anthony Magliocco, Douglas Marchion, Richard Klar, Sven Michel, Frank Jaschinski, Richard R. Reich, Shikhar Mehrotra, Juan R. Cubillos-Ruiz, David H. Munn, Jose R. Conejo-Garcia, Paulo C. Rodriguez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f05c7d9780cc4100b5638fc324c1bb21
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spelling	oai:doaj.org-article:f05c7d9780cc4100b5638fc324c1bb212021-12-02T14:35:31ZER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression10.1038/s41467-019-09263-12041-1723https://doaj.org/article/f05c7d9780cc4100b5638fc324c1bb212019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09263-1https://doaj.org/toc/2041-1723T-cell function impairment is one of the major determinants of tumour immune evasion. Here, the authors show that the hostile conditions in the tumour microenvironment lead to C/EBP homologous-protein upregulation in T cells via ER stress, resulting in repression of T-bet and consequent inhibition of CD8+ T cell function.”Yu CaoJimena Trillo-TinocoRosa A. SierraCarmen AnadonWenjie DaiEslam MohamedLing CenTara L. CostichAnthony MaglioccoDouglas MarchionRichard KlarSven MichelFrank JaschinskiRichard R. ReichShikhar MehrotraJuan R. Cubillos-RuizDavid H. MunnJose R. Conejo-GarciaPaulo C. RodriguezNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Cao Jimena Trillo-Tinoco Rosa A. Sierra Carmen Anadon Wenjie Dai Eslam Mohamed Ling Cen Tara L. Costich Anthony Magliocco Douglas Marchion Richard Klar Sven Michel Frank Jaschinski Richard R. Reich Shikhar Mehrotra Juan R. Cubillos-Ruiz David H. Munn Jose R. Conejo-Garcia Paulo C. Rodriguez ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
description	T-cell function impairment is one of the major determinants of tumour immune evasion. Here, the authors show that the hostile conditions in the tumour microenvironment lead to C/EBP homologous-protein upregulation in T cells via ER stress, resulting in repression of T-bet and consequent inhibition of CD8+ T cell function.”
format	article
author	Yu Cao Jimena Trillo-Tinoco Rosa A. Sierra Carmen Anadon Wenjie Dai Eslam Mohamed Ling Cen Tara L. Costich Anthony Magliocco Douglas Marchion Richard Klar Sven Michel Frank Jaschinski Richard R. Reich Shikhar Mehrotra Juan R. Cubillos-Ruiz David H. Munn Jose R. Conejo-Garcia Paulo C. Rodriguez
author_facet	Yu Cao Jimena Trillo-Tinoco Rosa A. Sierra Carmen Anadon Wenjie Dai Eslam Mohamed Ling Cen Tara L. Costich Anthony Magliocco Douglas Marchion Richard Klar Sven Michel Frank Jaschinski Richard R. Reich Shikhar Mehrotra Juan R. Cubillos-Ruiz David H. Munn Jose R. Conejo-Garcia Paulo C. Rodriguez
author_sort	Yu Cao
title	ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
title_short	ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
title_full	ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
title_fullStr	ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
title_full_unstemmed	ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
title_sort	er stress-induced mediator c/ebp homologous protein thwarts effector t cell activity in tumors through t-bet repression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f05c7d9780cc4100b5638fc324c1bb21
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ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression

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