Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

Insulin-related gene (Insig) negatively regulates hepatic fatty acid synthesis, a process involved in development of non-alcoholic fatty liver disease (NAFLD). Here, the authors show that AMPK activation by metformin promotes Insig phosphorylation, stabilizing it and inhibiting lipogenic gene expres...

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Autores principales: Yamei Han, Zhimin Hu, Aoyuan Cui, Zhengshuai Liu, Fengguang Ma, Yaqian Xue, Yuxiao Liu, Feifei Zhang, Zehua Zhao, Yanyan Yu, Jing Gao, Chun Wei, Jingya Li, Jing Fang, Jia Li, Jian-Gao Fan, Bao-Liang Song, Yu Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/f05d04d83bc04083ad1a7956edf7d357
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Sumario:Insulin-related gene (Insig) negatively regulates hepatic fatty acid synthesis, a process involved in development of non-alcoholic fatty liver disease (NAFLD). Here, the authors show that AMPK activation by metformin promotes Insig phosphorylation, stabilizing it and inhibiting lipogenic gene expression. This is protective against steatosis in diabetic mice.

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