Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

Insulin-related gene (Insig) negatively regulates hepatic fatty acid synthesis, a process involved in development of non-alcoholic fatty liver disease (NAFLD). Here, the authors show that AMPK activation by metformin promotes Insig phosphorylation, stabilizing it and inhibiting lipogenic gene expres...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yamei Han, Zhimin Hu, Aoyuan Cui, Zhengshuai Liu, Fengguang Ma, Yaqian Xue, Yuxiao Liu, Feifei Zhang, Zehua Zhao, Yanyan Yu, Jing Gao, Chun Wei, Jingya Li, Jing Fang, Jia Li, Jian-Gao Fan, Bao-Liang Song, Yu Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f05d04d83bc04083ad1a7956edf7d357
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f05d04d83bc04083ad1a7956edf7d357
record_format	dspace
spelling	oai:doaj.org-article:f05d04d83bc04083ad1a7956edf7d3572021-12-02T14:35:37ZPost-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene10.1038/s41467-019-08585-42041-1723https://doaj.org/article/f05d04d83bc04083ad1a7956edf7d3572019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08585-4https://doaj.org/toc/2041-1723Insulin-related gene (Insig) negatively regulates hepatic fatty acid synthesis, a process involved in development of non-alcoholic fatty liver disease (NAFLD). Here, the authors show that AMPK activation by metformin promotes Insig phosphorylation, stabilizing it and inhibiting lipogenic gene expression. This is protective against steatosis in diabetic mice.Yamei HanZhimin HuAoyuan CuiZhengshuai LiuFengguang MaYaqian XueYuxiao LiuFeifei ZhangZehua ZhaoYanyan YuJing GaoChun WeiJingya LiJing FangJia LiJian-Gao FanBao-Liang SongYu LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yamei Han Zhimin Hu Aoyuan Cui Zhengshuai Liu Fengguang Ma Yaqian Xue Yuxiao Liu Feifei Zhang Zehua Zhao Yanyan Yu Jing Gao Chun Wei Jingya Li Jing Fang Jia Li Jian-Gao Fan Bao-Liang Song Yu Li Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
description	Insulin-related gene (Insig) negatively regulates hepatic fatty acid synthesis, a process involved in development of non-alcoholic fatty liver disease (NAFLD). Here, the authors show that AMPK activation by metformin promotes Insig phosphorylation, stabilizing it and inhibiting lipogenic gene expression. This is protective against steatosis in diabetic mice.
format	article
author	Yamei Han Zhimin Hu Aoyuan Cui Zhengshuai Liu Fengguang Ma Yaqian Xue Yuxiao Liu Feifei Zhang Zehua Zhao Yanyan Yu Jing Gao Chun Wei Jingya Li Jing Fang Jia Li Jian-Gao Fan Bao-Liang Song Yu Li
author_facet	Yamei Han Zhimin Hu Aoyuan Cui Zhengshuai Liu Fengguang Ma Yaqian Xue Yuxiao Liu Feifei Zhang Zehua Zhao Yanyan Yu Jing Gao Chun Wei Jingya Li Jing Fang Jia Li Jian-Gao Fan Bao-Liang Song Yu Li
author_sort	Yamei Han
title	Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
title_short	Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
title_full	Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
title_fullStr	Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
title_full_unstemmed	Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
title_sort	post-translational regulation of lipogenesis via ampk-dependent phosphorylation of insulin-induced gene
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f05d04d83bc04083ad1a7956edf7d357
work_keys_str_mv	AT yameihan posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT zhiminhu posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT aoyuancui posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT zhengshuailiu posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT fengguangma posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT yaqianxue posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT yuxiaoliu posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT feifeizhang posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT zehuazhao posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT yanyanyu posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT jinggao posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT chunwei posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT jingyali posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT jingfang posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT jiali posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT jiangaofan posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT baoliangsong posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene AT yuli posttranslationalregulationoflipogenesisviaampkdependentphosphorylationofinsulininducedgene
_version_	1718391107921903616

Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

Ejemplares similares