3D direct printing of mechanical and biocompatible hydrogel meta-structures

Direct Ink Writing (DIW) has demonstrated great potential as a versatile method to 3D print multifunctional structures. In this work, we report the implementation of hydrogel meta-structures using DIW at room temperature, which seamlessly integrate large specific surface areas, interconnected porous...

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Autores principales:	Lei Zhang, Wenhan Lee, Xinhao Li, Yanhui Jiang, Nicholas Xuanlai Fang, Guohao Dai, Yongmin Liu
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Direct ink writing Gyroid meta-structure Mechanical-functional integration Naturally derived hydrogel Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f06144b984214f41bf70c953af508cdb
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spelling	oai:doaj.org-article:f06144b984214f41bf70c953af508cdb2021-11-26T04:36:45Z3D direct printing of mechanical and biocompatible hydrogel meta-structures2452-199X10.1016/j.bioactmat.2021.08.015https://doaj.org/article/f06144b984214f41bf70c953af508cdb2022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003911https://doaj.org/toc/2452-199XDirect Ink Writing (DIW) has demonstrated great potential as a versatile method to 3D print multifunctional structures. In this work, we report the implementation of hydrogel meta-structures using DIW at room temperature, which seamlessly integrate large specific surface areas, interconnected porous characteristics, mechanical toughness, biocompatibility, and water absorption and retention capabilities. Robust but hydrophobic polymers and weakly crosslinked nature-origin hydrogels form a balance in the self-supporting ink, allowing us to directly print complex meta-structures without sacrificial materials and heating extrusion. Mechanically, the mixed bending or stretching of symmetrical re-entrant cellular lattices and the unique curvature patterns are combined to provide little lateral expansion and large compressive energy absorbance when external forces are applied on the printed meta-structures. In addition, we have successfully demonstrated ear, aortic valve conduits and hierarchical architectures. We anticipate that the reported 3D meta-structured hydrogel would offer a new strategy to develop functional biomaterials for tissue engineering applications in the future.Lei ZhangWenhan LeeXinhao LiYanhui JiangNicholas Xuanlai FangGuohao DaiYongmin LiuKeAi Communications Co., Ltd.articleDirect ink writingGyroid meta-structureMechanical-functional integrationNaturally derived hydrogelMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 48-55 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Direct ink writing Gyroid meta-structure Mechanical-functional integration Naturally derived hydrogel Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Direct ink writing Gyroid meta-structure Mechanical-functional integration Naturally derived hydrogel Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Lei Zhang Wenhan Lee Xinhao Li Yanhui Jiang Nicholas Xuanlai Fang Guohao Dai Yongmin Liu 3D direct printing of mechanical and biocompatible hydrogel meta-structures
description	Direct Ink Writing (DIW) has demonstrated great potential as a versatile method to 3D print multifunctional structures. In this work, we report the implementation of hydrogel meta-structures using DIW at room temperature, which seamlessly integrate large specific surface areas, interconnected porous characteristics, mechanical toughness, biocompatibility, and water absorption and retention capabilities. Robust but hydrophobic polymers and weakly crosslinked nature-origin hydrogels form a balance in the self-supporting ink, allowing us to directly print complex meta-structures without sacrificial materials and heating extrusion. Mechanically, the mixed bending or stretching of symmetrical re-entrant cellular lattices and the unique curvature patterns are combined to provide little lateral expansion and large compressive energy absorbance when external forces are applied on the printed meta-structures. In addition, we have successfully demonstrated ear, aortic valve conduits and hierarchical architectures. We anticipate that the reported 3D meta-structured hydrogel would offer a new strategy to develop functional biomaterials for tissue engineering applications in the future.
format	article
author	Lei Zhang Wenhan Lee Xinhao Li Yanhui Jiang Nicholas Xuanlai Fang Guohao Dai Yongmin Liu
author_facet	Lei Zhang Wenhan Lee Xinhao Li Yanhui Jiang Nicholas Xuanlai Fang Guohao Dai Yongmin Liu
author_sort	Lei Zhang
title	3D direct printing of mechanical and biocompatible hydrogel meta-structures
title_short	3D direct printing of mechanical and biocompatible hydrogel meta-structures
title_full	3D direct printing of mechanical and biocompatible hydrogel meta-structures
title_fullStr	3D direct printing of mechanical and biocompatible hydrogel meta-structures
title_full_unstemmed	3D direct printing of mechanical and biocompatible hydrogel meta-structures
title_sort	3d direct printing of mechanical and biocompatible hydrogel meta-structures
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/f06144b984214f41bf70c953af508cdb
work_keys_str_mv	AT leizhang 3ddirectprintingofmechanicalandbiocompatiblehydrogelmetastructures AT wenhanlee 3ddirectprintingofmechanicalandbiocompatiblehydrogelmetastructures AT xinhaoli 3ddirectprintingofmechanicalandbiocompatiblehydrogelmetastructures AT yanhuijiang 3ddirectprintingofmechanicalandbiocompatiblehydrogelmetastructures AT nicholasxuanlaifang 3ddirectprintingofmechanicalandbiocompatiblehydrogelmetastructures AT guohaodai 3ddirectprintingofmechanicalandbiocompatiblehydrogelmetastructures AT yongminliu 3ddirectprintingofmechanicalandbiocompatiblehydrogelmetastructures
_version_	1718409876334444544

3D direct printing of mechanical and biocompatible hydrogel meta-structures

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