FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

Merkel cells are mechanoreceptors located in the epidermis whose developmental origin is unclear. Here the authors show that Merkel cells originate from SOX9 positive cells inside hair follicles and that FGFR2-mediated epithelial signalling is required for their specification.

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Autores principales:	Minh Binh Nguyen, Idan Cohen, Vinod Kumar, Zijian Xu, Carmit Bar, Katherine L. Dauber-Decker, Pai-Chi Tsai, Pauline Marangoni, Ophir D. Klein, Ya-Chieh Hsu, Ting Chen, Marja L. Mikkola, Elena Ezhkova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f06a4283856d4067bfcbe380ad9407b0
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spelling	oai:doaj.org-article:f06a4283856d4067bfcbe380ad9407b02021-12-02T15:33:34ZFGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells10.1038/s41467-018-04399-y2041-1723https://doaj.org/article/f06a4283856d4067bfcbe380ad9407b02018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04399-yhttps://doaj.org/toc/2041-1723Merkel cells are mechanoreceptors located in the epidermis whose developmental origin is unclear. Here the authors show that Merkel cells originate from SOX9 positive cells inside hair follicles and that FGFR2-mediated epithelial signalling is required for their specification.Minh Binh NguyenIdan CohenVinod KumarZijian XuCarmit BarKatherine L. Dauber-DeckerPai-Chi TsaiPauline MarangoniOphir D. KleinYa-Chieh HsuTing ChenMarja L. MikkolaElena EzhkovaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minh Binh Nguyen Idan Cohen Vinod Kumar Zijian Xu Carmit Bar Katherine L. Dauber-Decker Pai-Chi Tsai Pauline Marangoni Ophir D. Klein Ya-Chieh Hsu Ting Chen Marja L. Mikkola Elena Ezhkova FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
description	Merkel cells are mechanoreceptors located in the epidermis whose developmental origin is unclear. Here the authors show that Merkel cells originate from SOX9 positive cells inside hair follicles and that FGFR2-mediated epithelial signalling is required for their specification.
format	article
author	Minh Binh Nguyen Idan Cohen Vinod Kumar Zijian Xu Carmit Bar Katherine L. Dauber-Decker Pai-Chi Tsai Pauline Marangoni Ophir D. Klein Ya-Chieh Hsu Ting Chen Marja L. Mikkola Elena Ezhkova
author_facet	Minh Binh Nguyen Idan Cohen Vinod Kumar Zijian Xu Carmit Bar Katherine L. Dauber-Decker Pai-Chi Tsai Pauline Marangoni Ophir D. Klein Ya-Chieh Hsu Ting Chen Marja L. Mikkola Elena Ezhkova
author_sort	Minh Binh Nguyen
title	FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
title_short	FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
title_full	FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
title_fullStr	FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
title_full_unstemmed	FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
title_sort	fgf signalling controls the specification of hair placode-derived sox9 positive progenitors to merkel cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f06a4283856d4067bfcbe380ad9407b0
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FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

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