Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020
Resolving the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in households with members from different generations is crucial for containing the current pandemic. We conducted a large-scale, multicenter, cross-sectional seroepidemiologic household transmission stu...
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Centers for Disease Control and Prevention
2021
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oai:doaj.org-article:f06cb653e5b449bba8cbd210a9cf0e812021-11-22T12:56:37ZTransmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 202010.3201/eid2712.2109781080-60401080-6059https://doaj.org/article/f06cb653e5b449bba8cbd210a9cf0e812021-12-01T00:00:00Zhttps://wwwnc.cdc.gov/eid/article/27/12/21-0978_articlehttps://doaj.org/toc/1080-6040https://doaj.org/toc/1080-6059 Resolving the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in households with members from different generations is crucial for containing the current pandemic. We conducted a large-scale, multicenter, cross-sectional seroepidemiologic household transmission study in southwest Germany during May 11–August 1, 2020. We included 1,625 study participants from 405 households that each had ≥1 child and 1 reverse transcription PCR–confirmed SARS-CoV-2–infected index case-patient. The overall secondary attack rate was 31.6% and was significantly higher in exposed adults (37.5%) than in children (24.6%–29.2%; p = <0.015); the rate was also significantly higher when the index case-patient was >60 years of age (72.9%; p = 0.039). Other risk factors for infectiousness of the index case-patient were SARS-CoV-2–seropositivity (odds ratio [OR] 27.8, 95% CI 8.26–93.5), fever (OR 1.93, 95% CI 1.14–3.31), and cough (OR 2.07, 95% CI 1.21–3.53). Secondary infections in household contacts generate a substantial disease burden. Maximilian StichRoland EllingHanna RenkAleš JandaSven F. GarbadeBarbara MüllerHans-Georg KräusslichDorit FabriciusMaria ZernickelPeter MeissnerDaniela HuzlyJürgen Grulich-HennAnneke HaddadTessa GörneBenedikt SpielbergerLinus FritschAlexandra NietersHartmut HengelAndrea N. DietzThomas StammingerTina GanzenmuellerNatalia RuetaloAndreas PeterJonathan RemppisThomas IftnerKathrin JeltschTim WaterboerAxel R. FranzGeorg Friedrich HoffmannCorinna EngelKlaus-Michael DebatinBurkhard TönshoffPhilipp HennekeCenters for Disease Control and PreventionarticleCOVID-19coronavirus diseaseSARS-CoV-2severe acute respiratory syndrome coronavirus 2virusesrespiratory infectionsMedicineRInfectious and parasitic diseasesRC109-216ENEmerging Infectious Diseases, Vol 27, Iss 12, Pp 3009-3019 (2021) |
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DOAJ |
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EN |
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COVID-19 coronavirus disease SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses respiratory infections Medicine R Infectious and parasitic diseases RC109-216 |
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COVID-19 coronavirus disease SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses respiratory infections Medicine R Infectious and parasitic diseases RC109-216 Maximilian Stich Roland Elling Hanna Renk Aleš Janda Sven F. Garbade Barbara Müller Hans-Georg Kräusslich Dorit Fabricius Maria Zernickel Peter Meissner Daniela Huzly Jürgen Grulich-Henn Anneke Haddad Tessa Görne Benedikt Spielberger Linus Fritsch Alexandra Nieters Hartmut Hengel Andrea N. Dietz Thomas Stamminger Tina Ganzenmueller Natalia Ruetalo Andreas Peter Jonathan Remppis Thomas Iftner Kathrin Jeltsch Tim Waterboer Axel R. Franz Georg Friedrich Hoffmann Corinna Engel Klaus-Michael Debatin Burkhard Tönshoff Philipp Henneke Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020 |
| description |
Resolving the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in households with members from different generations is crucial for containing the current pandemic. We conducted a large-scale, multicenter, cross-sectional seroepidemiologic household transmission study in southwest Germany during May 11–August 1, 2020. We included 1,625 study participants from 405 households that each had ≥1 child and 1 reverse transcription PCR–confirmed SARS-CoV-2–infected index case-patient. The overall secondary attack rate was 31.6% and was significantly higher in exposed adults (37.5%) than in children (24.6%–29.2%; p = <0.015); the rate was also significantly higher when the index case-patient was >60 years of age (72.9%; p = 0.039). Other risk factors for infectiousness of the index case-patient were SARS-CoV-2–seropositivity (odds ratio [OR] 27.8, 95% CI 8.26–93.5), fever (OR 1.93, 95% CI 1.14–3.31), and cough (OR 2.07, 95% CI 1.21–3.53). Secondary infections in household contacts generate a substantial disease burden.
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| format |
article |
| author |
Maximilian Stich Roland Elling Hanna Renk Aleš Janda Sven F. Garbade Barbara Müller Hans-Georg Kräusslich Dorit Fabricius Maria Zernickel Peter Meissner Daniela Huzly Jürgen Grulich-Henn Anneke Haddad Tessa Görne Benedikt Spielberger Linus Fritsch Alexandra Nieters Hartmut Hengel Andrea N. Dietz Thomas Stamminger Tina Ganzenmueller Natalia Ruetalo Andreas Peter Jonathan Remppis Thomas Iftner Kathrin Jeltsch Tim Waterboer Axel R. Franz Georg Friedrich Hoffmann Corinna Engel Klaus-Michael Debatin Burkhard Tönshoff Philipp Henneke |
| author_facet |
Maximilian Stich Roland Elling Hanna Renk Aleš Janda Sven F. Garbade Barbara Müller Hans-Georg Kräusslich Dorit Fabricius Maria Zernickel Peter Meissner Daniela Huzly Jürgen Grulich-Henn Anneke Haddad Tessa Görne Benedikt Spielberger Linus Fritsch Alexandra Nieters Hartmut Hengel Andrea N. Dietz Thomas Stamminger Tina Ganzenmueller Natalia Ruetalo Andreas Peter Jonathan Remppis Thomas Iftner Kathrin Jeltsch Tim Waterboer Axel R. Franz Georg Friedrich Hoffmann Corinna Engel Klaus-Michael Debatin Burkhard Tönshoff Philipp Henneke |
| author_sort |
Maximilian Stich |
| title |
Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020 |
| title_short |
Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020 |
| title_full |
Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020 |
| title_fullStr |
Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020 |
| title_full_unstemmed |
Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020 |
| title_sort |
transmission of severe acute respiratory syndrome coronavirus 2 in households with children, southwest germany, may–august 2020 |
| publisher |
Centers for Disease Control and Prevention |
| publishDate |
2021 |
| url |
https://doaj.org/article/f06cb653e5b449bba8cbd210a9cf0e81 |
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