Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells

Obesity is associated with inflammation in adipose tissue, characterized by a shift in local T cell subsets. Here the authors show that loss of MHCII expression on adipocytes increases levels of immunosuppressive regulatory T cells in adipose tissue, which enhances insulin sensitivity.

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Autores principales:	Tuo Deng, Joey Liu, Yanru Deng, Laurie Minze, Xiang Xiao, Valerie Wright, Richeng Yu, Xian C. Li, Alecia Blaszczak, Stephen Bergin, David DiSilvestro, Ryan Judd, David Bradley, Michael Caligiuri, Christopher J. Lyon, Willa A. Hsueh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f06d437e5dce45deabca2a777dc8a491
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spelling	oai:doaj.org-article:f06d437e5dce45deabca2a777dc8a4912021-12-02T14:41:59ZAdipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells10.1038/ncomms157252041-1723https://doaj.org/article/f06d437e5dce45deabca2a777dc8a4912017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms15725https://doaj.org/toc/2041-1723Obesity is associated with inflammation in adipose tissue, characterized by a shift in local T cell subsets. Here the authors show that loss of MHCII expression on adipocytes increases levels of immunosuppressive regulatory T cells in adipose tissue, which enhances insulin sensitivity.Tuo DengJoey LiuYanru DengLaurie MinzeXiang XiaoValerie WrightRicheng YuXian C. LiAlecia BlaszczakStephen BerginDavid DiSilvestroRyan JuddDavid BradleyMichael CaligiuriChristopher J. LyonWilla A. HsuehNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tuo Deng Joey Liu Yanru Deng Laurie Minze Xiang Xiao Valerie Wright Richeng Yu Xian C. Li Alecia Blaszczak Stephen Bergin David DiSilvestro Ryan Judd David Bradley Michael Caligiuri Christopher J. Lyon Willa A. Hsueh Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells
description	Obesity is associated with inflammation in adipose tissue, characterized by a shift in local T cell subsets. Here the authors show that loss of MHCII expression on adipocytes increases levels of immunosuppressive regulatory T cells in adipose tissue, which enhances insulin sensitivity.
format	article
author	Tuo Deng Joey Liu Yanru Deng Laurie Minze Xiang Xiao Valerie Wright Richeng Yu Xian C. Li Alecia Blaszczak Stephen Bergin David DiSilvestro Ryan Judd David Bradley Michael Caligiuri Christopher J. Lyon Willa A. Hsueh
author_facet	Tuo Deng Joey Liu Yanru Deng Laurie Minze Xiang Xiao Valerie Wright Richeng Yu Xian C. Li Alecia Blaszczak Stephen Bergin David DiSilvestro Ryan Judd David Bradley Michael Caligiuri Christopher J. Lyon Willa A. Hsueh
author_sort	Tuo Deng
title	Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells
title_short	Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells
title_full	Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells
title_fullStr	Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells
title_full_unstemmed	Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells
title_sort	adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose treg cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f06d437e5dce45deabca2a777dc8a491
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Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells

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