Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody
Coxsackievirus A6 (CVA6) causes hand, foot and mouth disease in children. Here the authors present the CVA6 procapsid and A-particle cryo-EM structures and identify an immune-dominant neutralizing epitope, which can be exploited for vaccine development.
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Nature Portfolio
2017
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oai:doaj.org-article:f06de03619794e4cae31c9264a758c1f2021-12-02T14:40:26ZAtomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody10.1038/s41467-017-00477-92041-1723https://doaj.org/article/f06de03619794e4cae31c9264a758c1f2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00477-9https://doaj.org/toc/2041-1723Coxsackievirus A6 (CVA6) causes hand, foot and mouth disease in children. Here the authors present the CVA6 procapsid and A-particle cryo-EM structures and identify an immune-dominant neutralizing epitope, which can be exploited for vaccine development.Longfa XuQingbing ZhengShaowei LiMaozhou HeYangtao WuYongchao LiRui ZhuHai YuQiyang HongJie JiangZizhen LiShuxuan LiHuan ZhaoLisheng YangWangheng HouWei WangXiangzhong YeJun ZhangTimothy S. BakerTong ChengZ. Hong ZhouXiaodong YanNingshao XiaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Longfa Xu Qingbing Zheng Shaowei Li Maozhou He Yangtao Wu Yongchao Li Rui Zhu Hai Yu Qiyang Hong Jie Jiang Zizhen Li Shuxuan Li Huan Zhao Lisheng Yang Wangheng Hou Wei Wang Xiangzhong Ye Jun Zhang Timothy S. Baker Tong Cheng Z. Hong Zhou Xiaodong Yan Ningshao Xia Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody |
| description |
Coxsackievirus A6 (CVA6) causes hand, foot and mouth disease in children. Here the authors present the CVA6 procapsid and A-particle cryo-EM structures and identify an immune-dominant neutralizing epitope, which can be exploited for vaccine development. |
| format |
article |
| author |
Longfa Xu Qingbing Zheng Shaowei Li Maozhou He Yangtao Wu Yongchao Li Rui Zhu Hai Yu Qiyang Hong Jie Jiang Zizhen Li Shuxuan Li Huan Zhao Lisheng Yang Wangheng Hou Wei Wang Xiangzhong Ye Jun Zhang Timothy S. Baker Tong Cheng Z. Hong Zhou Xiaodong Yan Ningshao Xia |
| author_facet |
Longfa Xu Qingbing Zheng Shaowei Li Maozhou He Yangtao Wu Yongchao Li Rui Zhu Hai Yu Qiyang Hong Jie Jiang Zizhen Li Shuxuan Li Huan Zhao Lisheng Yang Wangheng Hou Wei Wang Xiangzhong Ye Jun Zhang Timothy S. Baker Tong Cheng Z. Hong Zhou Xiaodong Yan Ningshao Xia |
| author_sort |
Longfa Xu |
| title |
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody |
| title_short |
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody |
| title_full |
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody |
| title_fullStr |
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody |
| title_full_unstemmed |
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody |
| title_sort |
atomic structures of coxsackievirus a6 and its complex with a neutralizing antibody |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/f06de03619794e4cae31c9264a758c1f |
| work_keys_str_mv |
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| _version_ |
1718390331701985280 |