Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.

<h4>Background</h4>Essential hypertension (EH) with anxiety or depression belongs to the category of psycho-cardiology. Hypertension is closely related to anxiety and depression. The adverse reactions of Western medicine are apparent and the compliance is poor. Supplementary and replacem...

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Autores principales:	Xueyan Han, Xinxin Liu, Fengxing Zhong, Yiguo Wang, Qiming Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f06fb5eee8b74aafa5ad1fb79a7ab14e
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spelling	oai:doaj.org-article:f06fb5eee8b74aafa5ad1fb79a7ab14e2021-12-02T20:09:09ZComparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.1932-620310.1371/journal.pone.0254699https://doaj.org/article/f06fb5eee8b74aafa5ad1fb79a7ab14e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254699https://doaj.org/toc/1932-6203<h4>Background</h4>Essential hypertension (EH) with anxiety or depression belongs to the category of psycho-cardiology. Hypertension is closely related to anxiety and depression. The adverse reactions of Western medicine are apparent and the compliance is poor. Supplementary and replacement therapies have accumulated rich experience in clinical practices, which can reduce side effects and improve clinical efficacy. This study intends to use the Bayesian network meta-analysis (NMA) analysis method for the first time to gather randomized controlled trials (RCTs) related to complementary and alternative therapies in the treatment of hypertension with anxiety or depression disorder and rank efficacy and safety, to provide a reference basis for the treatment of hypertension with anxiety or depression disorder.<h4>Methods</h4>All randomized controlled trials (RCTs) and registered and ongoing trials of Chinese and English databases, related to supplementation and replacement therapies of EH with anxiety or depression disorder, published from initial state to February 2021, will be collected in the form of computer retrieval. Two researchers will independently screen the literature, extracting data, assessing bias risk and assessing heterogeneity. We will use software WinBUGS 1.4.3 and Stata 16.0 for pairwise meta-analysis and NMA to comprehensively evaluate various interventions. The quality of evidence will be evaluated through the Grading of Recommendations Assessment, Development and Evaluation (GRADE).<h4>Results</h4>This NMA will comprehensively compare and rank the efficacy and safety of a series of complementary and alternative therapies in treating EH with anxiety or depression disorder.<h4>Conclusion</h4>Supplementary and replacement therapies have accumulated rich experience of clinical practices in improving EH with anxiety or depression disorder. We expect that this NMA will guide practice and research by providing reliable evidence of evidence-based medicine for the treatment of EH with anxiety or depression disorder.<h4>Protocol registration number</h4>INPLASY202120068.Xueyan HanXinxin LiuFengxing ZhongYiguo WangQiming ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254699 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xueyan Han Xinxin Liu Fengxing Zhong Yiguo Wang Qiming Zhang Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.
description	<h4>Background</h4>Essential hypertension (EH) with anxiety or depression belongs to the category of psycho-cardiology. Hypertension is closely related to anxiety and depression. The adverse reactions of Western medicine are apparent and the compliance is poor. Supplementary and replacement therapies have accumulated rich experience in clinical practices, which can reduce side effects and improve clinical efficacy. This study intends to use the Bayesian network meta-analysis (NMA) analysis method for the first time to gather randomized controlled trials (RCTs) related to complementary and alternative therapies in the treatment of hypertension with anxiety or depression disorder and rank efficacy and safety, to provide a reference basis for the treatment of hypertension with anxiety or depression disorder.<h4>Methods</h4>All randomized controlled trials (RCTs) and registered and ongoing trials of Chinese and English databases, related to supplementation and replacement therapies of EH with anxiety or depression disorder, published from initial state to February 2021, will be collected in the form of computer retrieval. Two researchers will independently screen the literature, extracting data, assessing bias risk and assessing heterogeneity. We will use software WinBUGS 1.4.3 and Stata 16.0 for pairwise meta-analysis and NMA to comprehensively evaluate various interventions. The quality of evidence will be evaluated through the Grading of Recommendations Assessment, Development and Evaluation (GRADE).<h4>Results</h4>This NMA will comprehensively compare and rank the efficacy and safety of a series of complementary and alternative therapies in treating EH with anxiety or depression disorder.<h4>Conclusion</h4>Supplementary and replacement therapies have accumulated rich experience of clinical practices in improving EH with anxiety or depression disorder. We expect that this NMA will guide practice and research by providing reliable evidence of evidence-based medicine for the treatment of EH with anxiety or depression disorder.<h4>Protocol registration number</h4>INPLASY202120068.
format	article
author	Xueyan Han Xinxin Liu Fengxing Zhong Yiguo Wang Qiming Zhang
author_facet	Xueyan Han Xinxin Liu Fengxing Zhong Yiguo Wang Qiming Zhang
author_sort	Xueyan Han
title	Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.
title_short	Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.
title_full	Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.
title_fullStr	Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.
title_full_unstemmed	Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.
title_sort	comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f06fb5eee8b74aafa5ad1fb79a7ab14e
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Comparison of efficacy and safety of complementary and alternative therapies for essential hypertension with anxiety or depression disorder.

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