The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway

Alternative splicing of pre-mRNA increases transcriptome and proteome diversity by generating distinct isoforms that encode functionally diverse proteins, thus affecting many biological processes, including innate immunity. cGAS-STING signaling pathway, whose key molecules also undergo alternative s...

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Autores principales:	Jiaqian Liang, Ze Hong, Boyue Sun, Zhaoxi Guo, Chen Wang, Juanjuan Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	alternative splicing spliced isoforms cGAS-STING signaling pathway IFN response antiviral response Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f071fe819167418abe923d324ea88c9c
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spelling	oai:doaj.org-article:f071fe819167418abe923d324ea88c9c2021-11-18T05:09:08ZThe Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway1664-322410.3389/fimmu.2021.771744https://doaj.org/article/f071fe819167418abe923d324ea88c9c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.771744/fullhttps://doaj.org/toc/1664-3224Alternative splicing of pre-mRNA increases transcriptome and proteome diversity by generating distinct isoforms that encode functionally diverse proteins, thus affecting many biological processes, including innate immunity. cGAS-STING signaling pathway, whose key molecules also undergo alternative splicing, plays a crucial role in regulating innate immunity. Protein isoforms of key components in the cGAS-STING-TBK1-IRF3 axis have been detected in a variety of species. A chain of evidence showed that these protein isoforms exhibit distinct functions compared to their normal counterparts. The mentioned isoforms act as positive or negative modulators in interferon response via distinct mechanisms. Particularly, we highlight that alternative splicing serves a vital function for the host to avoid the overactivation of the cGAS-STING signaling pathway and that viruses can utilize alternative splicing to resist antiviral response by the host. These findings could provide insights for potential alternative splicing-targeting therapeutic applications.Jiaqian LiangZe HongBoyue SunZhaoxi GuoChen WangJuanjuan ZhuFrontiers Media S.A.articlealternative splicingspliced isoformscGAS-STING signaling pathwayIFN responseantiviral responseImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alternative splicing spliced isoforms cGAS-STING signaling pathway IFN response antiviral response Immunologic diseases. Allergy RC581-607
spellingShingle	alternative splicing spliced isoforms cGAS-STING signaling pathway IFN response antiviral response Immunologic diseases. Allergy RC581-607 Jiaqian Liang Ze Hong Boyue Sun Zhaoxi Guo Chen Wang Juanjuan Zhu The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway
description	Alternative splicing of pre-mRNA increases transcriptome and proteome diversity by generating distinct isoforms that encode functionally diverse proteins, thus affecting many biological processes, including innate immunity. cGAS-STING signaling pathway, whose key molecules also undergo alternative splicing, plays a crucial role in regulating innate immunity. Protein isoforms of key components in the cGAS-STING-TBK1-IRF3 axis have been detected in a variety of species. A chain of evidence showed that these protein isoforms exhibit distinct functions compared to their normal counterparts. The mentioned isoforms act as positive or negative modulators in interferon response via distinct mechanisms. Particularly, we highlight that alternative splicing serves a vital function for the host to avoid the overactivation of the cGAS-STING signaling pathway and that viruses can utilize alternative splicing to resist antiviral response by the host. These findings could provide insights for potential alternative splicing-targeting therapeutic applications.
format	article
author	Jiaqian Liang Ze Hong Boyue Sun Zhaoxi Guo Chen Wang Juanjuan Zhu
author_facet	Jiaqian Liang Ze Hong Boyue Sun Zhaoxi Guo Chen Wang Juanjuan Zhu
author_sort	Jiaqian Liang
title	The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway
title_short	The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway
title_full	The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway
title_fullStr	The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway
title_full_unstemmed	The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway
title_sort	alternatively spliced isoforms of key molecules in the cgas-sting signaling pathway
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f071fe819167418abe923d324ea88c9c
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The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway

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