Immunobiological properties of granulocytemacrophage colony-stimulating factor and synthetic peptides of his active center

Granulocyte-macrophage colony-stimulating factor (GM-CSF) belongs to the group of growth cytokines (hematopoietins) that regulate proliferation and differentiation of myeloid lineage cells. Recently, a lot of new data have accumulated, indicating the presence of a number of previously unknown biolog...

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Autores principales:	A. V. Zurochka, V. A. Zurochka, M. A. Dobrynina, V. A. Gritsenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	granulocyte-macrophage colony-stimulating factor synthetic peptide of the active center gm-csf-receptor immunobiological effects therapy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f0720519032d456a92b4063e8a6677f5
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spelling	oai:doaj.org-article:f0720519032d456a92b4063e8a6677f52021-11-18T08:03:51ZImmunobiological properties of granulocytemacrophage colony-stimulating factor and synthetic peptides of his active center1563-06252313-741X10.15789/1563-0625-IPO-2216https://doaj.org/article/f0720519032d456a92b4063e8a6677f52021-11-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2216https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XGranulocyte-macrophage colony-stimulating factor (GM-CSF) belongs to the group of growth cytokines (hematopoietins) that regulate proliferation and differentiation of myeloid lineage cells. Recently, a lot of new data have accumulated, indicating the presence of a number of previously unknown biological effects in GM-CSF and synthetic peptides of its active center, which open up new prospects for their wide clinical use.The review outlines current understanding of the structure, functions, and mechanisms of GM-CSF action and concerns the structure of its receptor. The GM-CSF producer cells are characterized, as well as target cells (effector cells) responding to this cytokine are also presented. The known mechanisms of intracellular signaling involved into the GM-CSF/receptor interaction are described. The main pleiotropic effects of this cytokine as a factor of hematopoiesis and an immunostimulating agent are characterized. The previously known and recently found immunobiological effects of this cytokine, its recombinant forms and synthetic analogues of its active center are discussed.Participation of GM-CSF in hematopoiesis and differentiation of myeloid cells, the effects of this cytokine on the functional activity of immunocompetent populations (lymphocytes, macrophages, neutrophils, dendritic cells) and tissue cells were characterized. The influence of GM-CSF on the development and course of infectious and inflammatory processes, its role in the creation of combined vaccines is reviewed. Clinical data on usage of GM-CSF and its recombinant forms in hematology, immunology, oncology, reproductive medicine and in the treatment of systemic autoimmune processes and infectious diseases are presented.The recently discovered immunobiological properties of synthetic peptides derived from active center of GM-CSF are summarized, indicating that they exhibit immunotropic and hematopoietic effects, as well as antimicrobial activity against Gram-negative and Gram-positive bacteria, viruses, and tissue repair (effect on the rate of wound healing), which is not typical to the whole GM-CSF molecule. We discuss the prospects for clinical applications of synthetic GM-CSF analogue (ZP2 peptide), and an opportunity of creating new cosmetics and pharmaceuticals with combined immunostimulating, antimicrobial and reparative properties on its basis.The review expands the view on potential usage of cytokine therapy in the treatment of various infectious and non-infectious diseases in humans, and is addressing a wide range of specialists working in the field of allergology and immunology, infectology and regenerative medicine.A. V. ZurochkaV. A. ZurochkaM. A. DobryninaV. A. GritsenkoSPb RAACIarticlegranulocyte-macrophage colony-stimulating factorsynthetic peptide of the active centergm-csf-receptorimmunobiological effectstherapyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 5, Pp 1031-1054 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	granulocyte-macrophage colony-stimulating factor synthetic peptide of the active center gm-csf-receptor immunobiological effects therapy Immunologic diseases. Allergy RC581-607
spellingShingle	granulocyte-macrophage colony-stimulating factor synthetic peptide of the active center gm-csf-receptor immunobiological effects therapy Immunologic diseases. Allergy RC581-607 A. V. Zurochka V. A. Zurochka M. A. Dobrynina V. A. Gritsenko Immunobiological properties of granulocytemacrophage colony-stimulating factor and synthetic peptides of his active center
description	Granulocyte-macrophage colony-stimulating factor (GM-CSF) belongs to the group of growth cytokines (hematopoietins) that regulate proliferation and differentiation of myeloid lineage cells. Recently, a lot of new data have accumulated, indicating the presence of a number of previously unknown biological effects in GM-CSF and synthetic peptides of its active center, which open up new prospects for their wide clinical use.The review outlines current understanding of the structure, functions, and mechanisms of GM-CSF action and concerns the structure of its receptor. The GM-CSF producer cells are characterized, as well as target cells (effector cells) responding to this cytokine are also presented. The known mechanisms of intracellular signaling involved into the GM-CSF/receptor interaction are described. The main pleiotropic effects of this cytokine as a factor of hematopoiesis and an immunostimulating agent are characterized. The previously known and recently found immunobiological effects of this cytokine, its recombinant forms and synthetic analogues of its active center are discussed.Participation of GM-CSF in hematopoiesis and differentiation of myeloid cells, the effects of this cytokine on the functional activity of immunocompetent populations (lymphocytes, macrophages, neutrophils, dendritic cells) and tissue cells were characterized. The influence of GM-CSF on the development and course of infectious and inflammatory processes, its role in the creation of combined vaccines is reviewed. Clinical data on usage of GM-CSF and its recombinant forms in hematology, immunology, oncology, reproductive medicine and in the treatment of systemic autoimmune processes and infectious diseases are presented.The recently discovered immunobiological properties of synthetic peptides derived from active center of GM-CSF are summarized, indicating that they exhibit immunotropic and hematopoietic effects, as well as antimicrobial activity against Gram-negative and Gram-positive bacteria, viruses, and tissue repair (effect on the rate of wound healing), which is not typical to the whole GM-CSF molecule. We discuss the prospects for clinical applications of synthetic GM-CSF analogue (ZP2 peptide), and an opportunity of creating new cosmetics and pharmaceuticals with combined immunostimulating, antimicrobial and reparative properties on its basis.The review expands the view on potential usage of cytokine therapy in the treatment of various infectious and non-infectious diseases in humans, and is addressing a wide range of specialists working in the field of allergology and immunology, infectology and regenerative medicine.
format	article
author	A. V. Zurochka V. A. Zurochka M. A. Dobrynina V. A. Gritsenko
author_facet	A. V. Zurochka V. A. Zurochka M. A. Dobrynina V. A. Gritsenko
author_sort	A. V. Zurochka
title	Immunobiological properties of granulocytemacrophage colony-stimulating factor and synthetic peptides of his active center
title_short	Immunobiological properties of granulocytemacrophage colony-stimulating factor and synthetic peptides of his active center
title_full	Immunobiological properties of granulocytemacrophage colony-stimulating factor and synthetic peptides of his active center
title_fullStr	Immunobiological properties of granulocytemacrophage colony-stimulating factor and synthetic peptides of his active center
title_full_unstemmed	Immunobiological properties of granulocytemacrophage colony-stimulating factor and synthetic peptides of his active center
title_sort	immunobiological properties of granulocytemacrophage colony-stimulating factor and synthetic peptides of his active center
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/f0720519032d456a92b4063e8a6677f5
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Immunobiological properties of granulocytemacrophage colony-stimulating factor and synthetic peptides of his active center

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