Advances in the Total Synthesis of Aflatoxins

Abstract: Aflatoxins, which are produced by Aspergillus flavus, Aspergillus nomius, and Aspergillus parasiticus, are a group of pentacyclic natural products with difuran and coumarin skeletons. They mainly include aflatoxin B1, B2, G1, G2, M1, and M2. Biologically, aflatoxins are of concern to human...

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Autores principales:	Liyan Yang, Zhonglei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	aflatoxins natural products contaminants total syntheses formal syntheses Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f074cc593a044f18aea3ba4431a4ae9f
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spelling	oai:doaj.org-article:f074cc593a044f18aea3ba4431a4ae9f2021-12-01T15:53:24ZAdvances in the Total Synthesis of Aflatoxins2296-264610.3389/fchem.2021.779765https://doaj.org/article/f074cc593a044f18aea3ba4431a4ae9f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.779765/fullhttps://doaj.org/toc/2296-2646Abstract: Aflatoxins, which are produced by Aspergillus flavus, Aspergillus nomius, and Aspergillus parasiticus, are a group of pentacyclic natural products with difuran and coumarin skeletons. They mainly include aflatoxin B1, B2, G1, G2, M1, and M2. Biologically, aflatoxins are of concern to human health as they can be present as contaminants in food products. The unique skeletons of aflatoxins and their risk to human health have led to the publication of nine remarkable total syntheses (including three asymmetric syntheses) and ten formal total syntheses (including four asymmetric formal syntheses) of aflatoxins in the past 55 years. To better understand the mechanism of the biological activity of aflatoxins and their presence in samples from the food industry, this review summarizes progress in the total synthesis of aflatoxins.Liyan YangZhonglei WangZhonglei WangZhonglei WangFrontiers Media S.A.articleaflatoxinsnatural productscontaminantstotal synthesesformal synthesesChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aflatoxins natural products contaminants total syntheses formal syntheses Chemistry QD1-999
spellingShingle	aflatoxins natural products contaminants total syntheses formal syntheses Chemistry QD1-999 Liyan Yang Zhonglei Wang Zhonglei Wang Zhonglei Wang Advances in the Total Synthesis of Aflatoxins
description	Abstract: Aflatoxins, which are produced by Aspergillus flavus, Aspergillus nomius, and Aspergillus parasiticus, are a group of pentacyclic natural products with difuran and coumarin skeletons. They mainly include aflatoxin B1, B2, G1, G2, M1, and M2. Biologically, aflatoxins are of concern to human health as they can be present as contaminants in food products. The unique skeletons of aflatoxins and their risk to human health have led to the publication of nine remarkable total syntheses (including three asymmetric syntheses) and ten formal total syntheses (including four asymmetric formal syntheses) of aflatoxins in the past 55 years. To better understand the mechanism of the biological activity of aflatoxins and their presence in samples from the food industry, this review summarizes progress in the total synthesis of aflatoxins.
format	article
author	Liyan Yang Zhonglei Wang Zhonglei Wang Zhonglei Wang
author_facet	Liyan Yang Zhonglei Wang Zhonglei Wang Zhonglei Wang
author_sort	Liyan Yang
title	Advances in the Total Synthesis of Aflatoxins
title_short	Advances in the Total Synthesis of Aflatoxins
title_full	Advances in the Total Synthesis of Aflatoxins
title_fullStr	Advances in the Total Synthesis of Aflatoxins
title_full_unstemmed	Advances in the Total Synthesis of Aflatoxins
title_sort	advances in the total synthesis of aflatoxins
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f074cc593a044f18aea3ba4431a4ae9f
work_keys_str_mv	AT liyanyang advancesinthetotalsynthesisofaflatoxins AT zhongleiwang advancesinthetotalsynthesisofaflatoxins AT zhongleiwang advancesinthetotalsynthesisofaflatoxins AT zhongleiwang advancesinthetotalsynthesisofaflatoxins
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Advances in the Total Synthesis of Aflatoxins

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