Effect of different direct-acting antiviral regimens for treatment of nondiabetic hepatitis C virus–infected Egyptian patients on insulin resistance and sensitivity

Abstract Background The association between hepatitis C virus (HCV), insulin resistance (IR), and metabolic syndrome has been extensively investigated. Direct-acting antivirals (DAAs) have a high sustained virologic response (SVR) rate, reaching > 90%. The effect of SVR after DAA treatment on met...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tarek Yosef, Wesam Ahmed Ibrahim, Ahmed El-Ghandour, Soha Attia, Sarah El-Nakeep
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Hepatitis C virus Direct-acting antivirals Insulin resistance Insulin sensitivity HOMA-IR Matsuda index Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/f074dadba7d641818293d546e4dc338e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f074dadba7d641818293d546e4dc338e
record_format	dspace
spelling	oai:doaj.org-article:f074dadba7d641818293d546e4dc338e2021-11-07T12:03:14ZEffect of different direct-acting antiviral regimens for treatment of nondiabetic hepatitis C virus–infected Egyptian patients on insulin resistance and sensitivity10.1186/s43162-021-00075-81110-77822090-9098https://doaj.org/article/f074dadba7d641818293d546e4dc338e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s43162-021-00075-8https://doaj.org/toc/1110-7782https://doaj.org/toc/2090-9098Abstract Background The association between hepatitis C virus (HCV), insulin resistance (IR), and metabolic syndrome has been extensively investigated. Direct-acting antivirals (DAAs) have a high sustained virologic response (SVR) rate, reaching > 90%. The effect of SVR after DAA treatment on metabolic parameters and IR in nondiabetic patients could be an important factor in the patient’s long-term outcome. The aim of the study is to evaluate the impact of different DAA regimens on IR and sensitivity in naïve chronic HCV-infected nondiabetic patients (before and after 12 weeks of treatment). Methods This prospective cohort study was conducted on 100 HCV-infected Child A nondiabetic patients eligible for DAA treatment in the Department of Gastroenterology and Hepatology, Ain Shams University, and Kobry El-Kobba Military Hospital among patients attending the outpatient clinic. Patients were categorized into four groups according to the HCV regimens they received for 12 weeks. All patient were subjected to the following tests before and 12 weeks after treatment: HCV quantitative PCR, Fibroscan, fasting insulin level (using insulin quantitative test kit), fasting and postprandial blood glucose (PPG), lipid profile, liver enzymes, BMI, and waist circumference. Results All patients achieved SVR at 12 weeks. In all treatment groups, lab was assessed before and after treatment, the 2-h PPG, high-density lipoprotein, and low-density lipoprotein levels showed statistically significant increases, whereas triglyceride, fasting glucose, hemoglobin A1C, and fasting plasma insulin levels showed statistically significant decreases. The homeostasis model assessment of insulin resistance (HOMA-IR) exhibited statistically significant decreases, whereas the quantitative insulin sensitivity check index (QUICKI) and Matsuda index showed statistically significant increases, across the four groups. Conclusions DAA treatment in naïve nondiabetic HCV-infected patients affects metabolic profile and insulin resistance/sensitivity, with similar effect among different DAA regimens.Tarek YosefWesam Ahmed IbrahimAhmed El-GhandourSoha AttiaSarah El-NakeepSpringerOpenarticleHepatitis C virusDirect-acting antiviralsInsulin resistanceInsulin sensitivityHOMA-IRMatsuda indexInternal medicineRC31-1245ENThe Egyptian Journal of Internal Medicine, Vol 33, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hepatitis C virus Direct-acting antivirals Insulin resistance Insulin sensitivity HOMA-IR Matsuda index Internal medicine RC31-1245
spellingShingle	Hepatitis C virus Direct-acting antivirals Insulin resistance Insulin sensitivity HOMA-IR Matsuda index Internal medicine RC31-1245 Tarek Yosef Wesam Ahmed Ibrahim Ahmed El-Ghandour Soha Attia Sarah El-Nakeep Effect of different direct-acting antiviral regimens for treatment of nondiabetic hepatitis C virus–infected Egyptian patients on insulin resistance and sensitivity
description	Abstract Background The association between hepatitis C virus (HCV), insulin resistance (IR), and metabolic syndrome has been extensively investigated. Direct-acting antivirals (DAAs) have a high sustained virologic response (SVR) rate, reaching > 90%. The effect of SVR after DAA treatment on metabolic parameters and IR in nondiabetic patients could be an important factor in the patient’s long-term outcome. The aim of the study is to evaluate the impact of different DAA regimens on IR and sensitivity in naïve chronic HCV-infected nondiabetic patients (before and after 12 weeks of treatment). Methods This prospective cohort study was conducted on 100 HCV-infected Child A nondiabetic patients eligible for DAA treatment in the Department of Gastroenterology and Hepatology, Ain Shams University, and Kobry El-Kobba Military Hospital among patients attending the outpatient clinic. Patients were categorized into four groups according to the HCV regimens they received for 12 weeks. All patient were subjected to the following tests before and 12 weeks after treatment: HCV quantitative PCR, Fibroscan, fasting insulin level (using insulin quantitative test kit), fasting and postprandial blood glucose (PPG), lipid profile, liver enzymes, BMI, and waist circumference. Results All patients achieved SVR at 12 weeks. In all treatment groups, lab was assessed before and after treatment, the 2-h PPG, high-density lipoprotein, and low-density lipoprotein levels showed statistically significant increases, whereas triglyceride, fasting glucose, hemoglobin A1C, and fasting plasma insulin levels showed statistically significant decreases. The homeostasis model assessment of insulin resistance (HOMA-IR) exhibited statistically significant decreases, whereas the quantitative insulin sensitivity check index (QUICKI) and Matsuda index showed statistically significant increases, across the four groups. Conclusions DAA treatment in naïve nondiabetic HCV-infected patients affects metabolic profile and insulin resistance/sensitivity, with similar effect among different DAA regimens.
format	article
author	Tarek Yosef Wesam Ahmed Ibrahim Ahmed El-Ghandour Soha Attia Sarah El-Nakeep
author_facet	Tarek Yosef Wesam Ahmed Ibrahim Ahmed El-Ghandour Soha Attia Sarah El-Nakeep
author_sort	Tarek Yosef
title	Effect of different direct-acting antiviral regimens for treatment of nondiabetic hepatitis C virus–infected Egyptian patients on insulin resistance and sensitivity
title_short	Effect of different direct-acting antiviral regimens for treatment of nondiabetic hepatitis C virus–infected Egyptian patients on insulin resistance and sensitivity
title_full	Effect of different direct-acting antiviral regimens for treatment of nondiabetic hepatitis C virus–infected Egyptian patients on insulin resistance and sensitivity
title_fullStr	Effect of different direct-acting antiviral regimens for treatment of nondiabetic hepatitis C virus–infected Egyptian patients on insulin resistance and sensitivity
title_full_unstemmed	Effect of different direct-acting antiviral regimens for treatment of nondiabetic hepatitis C virus–infected Egyptian patients on insulin resistance and sensitivity
title_sort	effect of different direct-acting antiviral regimens for treatment of nondiabetic hepatitis c virus–infected egyptian patients on insulin resistance and sensitivity
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/f074dadba7d641818293d546e4dc338e
work_keys_str_mv	AT tarekyosef effectofdifferentdirectactingantiviralregimensfortreatmentofnondiabetichepatitiscvirusinfectedegyptianpatientsoninsulinresistanceandsensitivity AT wesamahmedibrahim effectofdifferentdirectactingantiviralregimensfortreatmentofnondiabetichepatitiscvirusinfectedegyptianpatientsoninsulinresistanceandsensitivity AT ahmedelghandour effectofdifferentdirectactingantiviralregimensfortreatmentofnondiabetichepatitiscvirusinfectedegyptianpatientsoninsulinresistanceandsensitivity AT sohaattia effectofdifferentdirectactingantiviralregimensfortreatmentofnondiabetichepatitiscvirusinfectedegyptianpatientsoninsulinresistanceandsensitivity AT sarahelnakeep effectofdifferentdirectactingantiviralregimensfortreatmentofnondiabetichepatitiscvirusinfectedegyptianpatientsoninsulinresistanceandsensitivity
_version_	1718443584344031232

Effect of different direct-acting antiviral regimens for treatment of nondiabetic hepatitis C virus–infected Egyptian patients on insulin resistance and sensitivity

Ejemplares similares