Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications

Gelatin, a denatured form of collagen, is an attractive biomaterial for biotechnology. In particular, gelatin particles have been noted due to their attractive properties as drug carriers. The drug release from gelatin particles can be easily controlled by the crosslinking degree of gelatin molecule...

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Autor principal:	Teruki Nii
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biotechnology drug delivery drug research model gelatin regenerative medicine Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/f07697e925264decb94817d39280b785
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spelling	oai:doaj.org-article:f07697e925264decb94817d39280b7852021-11-25T18:27:17ZStrategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications10.3390/molecules262267951420-3049https://doaj.org/article/f07697e925264decb94817d39280b7852021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6795https://doaj.org/toc/1420-3049Gelatin, a denatured form of collagen, is an attractive biomaterial for biotechnology. In particular, gelatin particles have been noted due to their attractive properties as drug carriers. The drug release from gelatin particles can be easily controlled by the crosslinking degree of gelatin molecule, responding to the purpose of the research. The gelatin particles capable of drug release are effective in wound healing, drug screening models. For example, a sustained release of growth factors for tissue regeneration at the injured sites can heal a wound. In the case of the drug screening model, a tissue-like model composed of cells with high activity by the sustained release of drug or growth factor provides reliable results of drug effects. Gelatin particles are effective in drug delivery and the culture of spheroids or cell sheets because the particles prevent hypoxia-derived cell death. This review introduces recent research on gelatin microparticles-based strategies for regenerative therapy and drug screening models.Teruki NiiMDPI AGarticlebiotechnologydrug deliverydrug research modelgelatinregenerative medicineOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6795, p 6795 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biotechnology drug delivery drug research model gelatin regenerative medicine Organic chemistry QD241-441
spellingShingle	biotechnology drug delivery drug research model gelatin regenerative medicine Organic chemistry QD241-441 Teruki Nii Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications
description	Gelatin, a denatured form of collagen, is an attractive biomaterial for biotechnology. In particular, gelatin particles have been noted due to their attractive properties as drug carriers. The drug release from gelatin particles can be easily controlled by the crosslinking degree of gelatin molecule, responding to the purpose of the research. The gelatin particles capable of drug release are effective in wound healing, drug screening models. For example, a sustained release of growth factors for tissue regeneration at the injured sites can heal a wound. In the case of the drug screening model, a tissue-like model composed of cells with high activity by the sustained release of drug or growth factor provides reliable results of drug effects. Gelatin particles are effective in drug delivery and the culture of spheroids or cell sheets because the particles prevent hypoxia-derived cell death. This review introduces recent research on gelatin microparticles-based strategies for regenerative therapy and drug screening models.
format	article
author	Teruki Nii
author_facet	Teruki Nii
author_sort	Teruki Nii
title	Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications
title_short	Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications
title_full	Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications
title_fullStr	Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications
title_full_unstemmed	Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications
title_sort	strategies using gelatin microparticles for regenerative therapy and drug screening applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f07697e925264decb94817d39280b785
work_keys_str_mv	AT terukinii strategiesusinggelatinmicroparticlesforregenerativetherapyanddrugscreeningapplications
_version_	1718411170203828224

Strategies Using Gelatin Microparticles for Regenerative Therapy and Drug Screening Applications

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