IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

The role of IFI16 as a DNA sensor is highly controversial. With support from a Nature Communications back-to-back publication from Almineet al. the authors here provide functional evidence that IFI16 is required for DNA sensing via the cGAS-STING pathway in human macrophages.

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Autores principales:	K. L. Jønsson, A. Laustsen, C. Krapp, K. A. Skipper, K. Thavachelvam, D. Hotter, J. H. Egedal, M. Kjolby, P. Mohammadi, T. Prabakaran, L. K. Sørensen, C. Sun, S. B. Jensen, C. K. Holm, R. J. Lebbink, M. Johannsen, M. Nyegaard, J. G. Mikkelsen, F. Kirchhoff, S. R. Paludan, M. R. Jakobsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f077d067175040ebb442e5ac090773d6
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spelling	oai:doaj.org-article:f077d067175040ebb442e5ac090773d62021-12-02T14:42:07ZIFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP10.1038/ncomms143912041-1723https://doaj.org/article/f077d067175040ebb442e5ac090773d62017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14391https://doaj.org/toc/2041-1723The role of IFI16 as a DNA sensor is highly controversial. With support from a Nature Communications back-to-back publication from Almineet al. the authors here provide functional evidence that IFI16 is required for DNA sensing via the cGAS-STING pathway in human macrophages.K. L. JønssonA. LaustsenC. KrappK. A. SkipperK. ThavachelvamD. HotterJ. H. EgedalM. KjolbyP. MohammadiT. PrabakaranL. K. SørensenC. SunS. B. JensenC. K. HolmR. J. LebbinkM. JohannsenM. NyegaardJ. G. MikkelsenF. KirchhoffS. R. PaludanM. R. JakobsenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q K. L. Jønsson A. Laustsen C. Krapp K. A. Skipper K. Thavachelvam D. Hotter J. H. Egedal M. Kjolby P. Mohammadi T. Prabakaran L. K. Sørensen C. Sun S. B. Jensen C. K. Holm R. J. Lebbink M. Johannsen M. Nyegaard J. G. Mikkelsen F. Kirchhoff S. R. Paludan M. R. Jakobsen IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
description	The role of IFI16 as a DNA sensor is highly controversial. With support from a Nature Communications back-to-back publication from Almineet al. the authors here provide functional evidence that IFI16 is required for DNA sensing via the cGAS-STING pathway in human macrophages.
format	article
author	K. L. Jønsson A. Laustsen C. Krapp K. A. Skipper K. Thavachelvam D. Hotter J. H. Egedal M. Kjolby P. Mohammadi T. Prabakaran L. K. Sørensen C. Sun S. B. Jensen C. K. Holm R. J. Lebbink M. Johannsen M. Nyegaard J. G. Mikkelsen F. Kirchhoff S. R. Paludan M. R. Jakobsen
author_facet	K. L. Jønsson A. Laustsen C. Krapp K. A. Skipper K. Thavachelvam D. Hotter J. H. Egedal M. Kjolby P. Mohammadi T. Prabakaran L. K. Sørensen C. Sun S. B. Jensen C. K. Holm R. J. Lebbink M. Johannsen M. Nyegaard J. G. Mikkelsen F. Kirchhoff S. R. Paludan M. R. Jakobsen
author_sort	K. L. Jønsson
title	IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
title_short	IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
title_full	IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
title_fullStr	IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
title_full_unstemmed	IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
title_sort	ifi16 is required for dna sensing in human macrophages by promoting production and function of cgamp
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f077d067175040ebb442e5ac090773d6
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IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

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