Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa

Rhodopsin-related dominant retinitis pigmentosa is a degenerative disease of the retina of the eye for which there is no current treatment. In this study, the authors use a novel form of RNA-interference- artificial mirtrons- to slow retinal degeneration in a mouse model of the disease.

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Autores principales:	Harry O. Orlans, Michelle E. McClements, Alun R. Barnard, Cristina Martinez-Fernandez de la Camara, Robert E. MacLaren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f079a2227d8741e1858d4c8fe8a57b28
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spelling	oai:doaj.org-article:f079a2227d8741e1858d4c8fe8a57b282021-12-02T18:01:12ZMirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa10.1038/s41467-021-25204-32041-1723https://doaj.org/article/f079a2227d8741e1858d4c8fe8a57b282021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25204-3https://doaj.org/toc/2041-1723Rhodopsin-related dominant retinitis pigmentosa is a degenerative disease of the retina of the eye for which there is no current treatment. In this study, the authors use a novel form of RNA-interference- artificial mirtrons- to slow retinal degeneration in a mouse model of the disease.Harry O. OrlansMichelle E. McClementsAlun R. BarnardCristina Martinez-Fernandez de la CamaraRobert E. MacLarenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Harry O. Orlans Michelle E. McClements Alun R. Barnard Cristina Martinez-Fernandez de la Camara Robert E. MacLaren Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa
description	Rhodopsin-related dominant retinitis pigmentosa is a degenerative disease of the retina of the eye for which there is no current treatment. In this study, the authors use a novel form of RNA-interference- artificial mirtrons- to slow retinal degeneration in a mouse model of the disease.
format	article
author	Harry O. Orlans Michelle E. McClements Alun R. Barnard Cristina Martinez-Fernandez de la Camara Robert E. MacLaren
author_facet	Harry O. Orlans Michelle E. McClements Alun R. Barnard Cristina Martinez-Fernandez de la Camara Robert E. MacLaren
author_sort	Harry O. Orlans
title	Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa
title_short	Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa
title_full	Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa
title_fullStr	Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa
title_full_unstemmed	Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa
title_sort	mirtron-mediated rna knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f079a2227d8741e1858d4c8fe8a57b28
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Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa

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