Objective Evaluation Of On-Eye Optical Quality Of Daily Disposable Silicone Hydrogel Contact Lens With Internal Wetting Agents

Shizuka Koh,1,2 Kiyoshi Watanabe,3 Kohji Nishida2 1Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan; 2Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan; 3Watanabe Eye Clinic, Osaka, JapanCorrespondence: Shizuka...

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Autores principales:	Koh S, Watanabe K, Nishida K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	visual performance quantitative assessment surface lens wettability Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f07eb2b122bd48dc8adba92d766f5fbb
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spelling	oai:doaj.org-article:f07eb2b122bd48dc8adba92d766f5fbb2021-12-02T09:23:21ZObjective Evaluation Of On-Eye Optical Quality Of Daily Disposable Silicone Hydrogel Contact Lens With Internal Wetting Agents1177-5483https://doaj.org/article/f07eb2b122bd48dc8adba92d766f5fbb2019-11-01T00:00:00Zhttps://www.dovepress.com/objective-evaluation-of-on-eye-optical-quality-of-daily-disposable-sil-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Shizuka Koh,1,2 Kiyoshi Watanabe,3 Kohji Nishida2 1Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan; 2Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan; 3Watanabe Eye Clinic, Osaka, JapanCorrespondence: Shizuka KohDepartment Of Innovative Visual Science, Osaka University Graduate School Of Medicine, Room E7, 2-2 Yamadaoka, Osaka 565-0871, JapanTel +81-6-6879-3456Fax +81-6-6879-3458Email skoh@ophthal.med.osaka-u.ac.jpPurpose: To investigate the on-eye optical quality of a daily disposable silicone hydrogel contact lens with internal wetting agent.Patients and methods: Study subjects were daily disposable soft contact lens wearers (N=20) who were instructed to wear daily disposable hydrogel etafilcon A lens (without added wetting agent) or daily disposable silicone hydrogel senofilcon A lens (with an internal wetting agent), for a week. Subjects wore their respective lenses bilaterally and disposed of the pair of lenses daily. At the end of the 1-week test-wear period, the on-eye visual performances of the lens and the ocular surfaces were evaluated. A wavefront sensor measured sequential ocular higher-order aberrations (HOAs) for 10 s after the blink. The aberration data were analyzed in the central 4-mm diameter up to the sixth-order Zernike polynomials. Total HOAs, fluctuation index (FI), and stability index (SI) of the total HOAs over time were compared between the two lenses. Ocular surface evaluation with fluorescein was performed following the wavefront measurement.Results: The senofilcon A lens had significantly lower average total HOAs, FI, and SI (p<0.001, p=0.001, p=0.007, respectively) than the etafilcon A lens. After 1-week wear of each lens, corneal staining was observed in eight subjects (40%) with the etafilcon A lens and in two subjects (10%) with the senofilcon A lens. The senofilcon A lens had significantly lower incidence of corneal staining than the etafilcon A lens (p=0.041).Conclusion: Quantitative sequential measurement of HOAs objectively showed the possibility of better and more stable optical quality with silicone hydrogel daily disposable contact lens with the internal wetting agent than with hydrogel lens without the added wetting agent.Keywords: visual performance, quantitative assessment, surface lens wettabilityKoh SWatanabe KNishida KDove Medical Pressarticlevisual performancequantitative assessmentsurface lens wettabilityOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 2159-2165 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	visual performance quantitative assessment surface lens wettability Ophthalmology RE1-994
spellingShingle	visual performance quantitative assessment surface lens wettability Ophthalmology RE1-994 Koh S Watanabe K Nishida K Objective Evaluation Of On-Eye Optical Quality Of Daily Disposable Silicone Hydrogel Contact Lens With Internal Wetting Agents
description	Shizuka Koh,1,2 Kiyoshi Watanabe,3 Kohji Nishida2 1Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan; 2Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan; 3Watanabe Eye Clinic, Osaka, JapanCorrespondence: Shizuka KohDepartment Of Innovative Visual Science, Osaka University Graduate School Of Medicine, Room E7, 2-2 Yamadaoka, Osaka 565-0871, JapanTel +81-6-6879-3456Fax +81-6-6879-3458Email skoh@ophthal.med.osaka-u.ac.jpPurpose: To investigate the on-eye optical quality of a daily disposable silicone hydrogel contact lens with internal wetting agent.Patients and methods: Study subjects were daily disposable soft contact lens wearers (N=20) who were instructed to wear daily disposable hydrogel etafilcon A lens (without added wetting agent) or daily disposable silicone hydrogel senofilcon A lens (with an internal wetting agent), for a week. Subjects wore their respective lenses bilaterally and disposed of the pair of lenses daily. At the end of the 1-week test-wear period, the on-eye visual performances of the lens and the ocular surfaces were evaluated. A wavefront sensor measured sequential ocular higher-order aberrations (HOAs) for 10 s after the blink. The aberration data were analyzed in the central 4-mm diameter up to the sixth-order Zernike polynomials. Total HOAs, fluctuation index (FI), and stability index (SI) of the total HOAs over time were compared between the two lenses. Ocular surface evaluation with fluorescein was performed following the wavefront measurement.Results: The senofilcon A lens had significantly lower average total HOAs, FI, and SI (p<0.001, p=0.001, p=0.007, respectively) than the etafilcon A lens. After 1-week wear of each lens, corneal staining was observed in eight subjects (40%) with the etafilcon A lens and in two subjects (10%) with the senofilcon A lens. The senofilcon A lens had significantly lower incidence of corneal staining than the etafilcon A lens (p=0.041).Conclusion: Quantitative sequential measurement of HOAs objectively showed the possibility of better and more stable optical quality with silicone hydrogel daily disposable contact lens with the internal wetting agent than with hydrogel lens without the added wetting agent.Keywords: visual performance, quantitative assessment, surface lens wettability
format	article
author	Koh S Watanabe K Nishida K
author_facet	Koh S Watanabe K Nishida K
author_sort	Koh S
title	Objective Evaluation Of On-Eye Optical Quality Of Daily Disposable Silicone Hydrogel Contact Lens With Internal Wetting Agents
title_short	Objective Evaluation Of On-Eye Optical Quality Of Daily Disposable Silicone Hydrogel Contact Lens With Internal Wetting Agents
title_full	Objective Evaluation Of On-Eye Optical Quality Of Daily Disposable Silicone Hydrogel Contact Lens With Internal Wetting Agents
title_fullStr	Objective Evaluation Of On-Eye Optical Quality Of Daily Disposable Silicone Hydrogel Contact Lens With Internal Wetting Agents
title_full_unstemmed	Objective Evaluation Of On-Eye Optical Quality Of Daily Disposable Silicone Hydrogel Contact Lens With Internal Wetting Agents
title_sort	objective evaluation of on-eye optical quality of daily disposable silicone hydrogel contact lens with internal wetting agents
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f07eb2b122bd48dc8adba92d766f5fbb
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Objective Evaluation Of On-Eye Optical Quality Of Daily Disposable Silicone Hydrogel Contact Lens With Internal Wetting Agents

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