Role and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma

Cancer/testis (CT) antigens exhibit selective expression predominantly in immunoprivileged tissues in non-pathological contexts but are aberrantly expressed in diverse cancers. Due to their expression pattern, they have historically been attractive targets for immunotherapies. A growing number of st...

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Autores principales:	Sharon Changshan Wu, Karl Münger
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	CT antigens HNSCC HPV Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f08826ba092240778bfd49fa7117c566
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spelling	oai:doaj.org-article:f08826ba092240778bfd49fa7117c5662021-11-25T17:02:41ZRole and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma10.3390/cancers132256902072-6694https://doaj.org/article/f08826ba092240778bfd49fa7117c5662021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5690https://doaj.org/toc/2072-6694Cancer/testis (CT) antigens exhibit selective expression predominantly in immunoprivileged tissues in non-pathological contexts but are aberrantly expressed in diverse cancers. Due to their expression pattern, they have historically been attractive targets for immunotherapies. A growing number of studies implicate CT antigens in almost all hallmarks of cancer, suggesting that they may act as cancer drivers. CT antigens are expressed in head and neck squamous cell carcinomas. However, their role in the pathogenesis of these cancers remains poorly studied. Given that CT antigens hold intriguing potential as therapeutic targets and as biomarkers for prognosis and that they can provide novel insights into oncogenic mechanisms, their further study in the context of head and squamous cell carcinoma is warranted.Sharon Changshan WuKarl MüngerMDPI AGarticleCT antigensHNSCCHPVNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5690, p 5690 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CT antigens HNSCC HPV Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	CT antigens HNSCC HPV Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sharon Changshan Wu Karl Münger Role and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma
description	Cancer/testis (CT) antigens exhibit selective expression predominantly in immunoprivileged tissues in non-pathological contexts but are aberrantly expressed in diverse cancers. Due to their expression pattern, they have historically been attractive targets for immunotherapies. A growing number of studies implicate CT antigens in almost all hallmarks of cancer, suggesting that they may act as cancer drivers. CT antigens are expressed in head and neck squamous cell carcinomas. However, their role in the pathogenesis of these cancers remains poorly studied. Given that CT antigens hold intriguing potential as therapeutic targets and as biomarkers for prognosis and that they can provide novel insights into oncogenic mechanisms, their further study in the context of head and squamous cell carcinoma is warranted.
format	article
author	Sharon Changshan Wu Karl Münger
author_facet	Sharon Changshan Wu Karl Münger
author_sort	Sharon Changshan Wu
title	Role and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma
title_short	Role and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma
title_full	Role and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma
title_fullStr	Role and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed	Role and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma
title_sort	role and clinical utility of cancer/testis antigens in head and neck squamous cell carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f08826ba092240778bfd49fa7117c566
work_keys_str_mv	AT sharonchangshanwu roleandclinicalutilityofcancertestisantigensinheadandnecksquamouscellcarcinoma AT karlmunger roleandclinicalutilityofcancertestisantigensinheadandnecksquamouscellcarcinoma
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Role and Clinical Utility of Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma

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