Seroprevalence and risk factors of chikungunya virus infection in Mayotte, Indian Ocean, 2005-2006: a population-based survey.

<h4>Background</h4>Since 2006, Chikungunya virus (CHIKV) has re-emerged as an important pathogen of global concern. However, individual and household factors associated with the acquisition and the magnitude of clinically silent CHIKV infections remain poorly understood. In this present...

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Autores principales:	Daouda Sissoko, Amrat Moendandze, Denis Malvy, Claude Giry, Khaled Ezzedine, Jean Louis Solet, Vincent Pierre
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f08c1b3acddf4d8198ee80953a58b91f
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spelling	oai:doaj.org-article:f08c1b3acddf4d8198ee80953a58b91f2021-11-25T06:18:51ZSeroprevalence and risk factors of chikungunya virus infection in Mayotte, Indian Ocean, 2005-2006: a population-based survey.1932-620310.1371/journal.pone.0003066https://doaj.org/article/f08c1b3acddf4d8198ee80953a58b91f2008-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18725980/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Since 2006, Chikungunya virus (CHIKV) has re-emerged as an important pathogen of global concern. However, individual and household factors associated with the acquisition and the magnitude of clinically silent CHIKV infections remain poorly understood. In this present study, we aimed to investigate the seroprevalence, estimate the proportion of symptomatic illness and identify the risk factors for CHIKV infection in the primo-exposed population of Mayotte. METHODS/ PRINCIPAL FINDINGS: We conducted a household-based cross sectional serosurvey in Mayotte in November and December 2006 using complex multistage cluster sampling. To produce the results representative of the island population aged 2 years or older, sample data were adjusted with sample weights. Explanatory and multiple logistic regression analyses were performed to investigate associations between CHIKV infection seropositivity (presence of IgM and/or IgG to CHIKV by enzyme-linked immunoabsorbent assay) and risk factors. A total of 1154 individuals were analyzed. The overall seroprevalence of CHIKV infection was 37.2% (95% CI = 33.9-40.5), 318 (72.3%) of the seropositive participants reported symptoms consistent with a CHIKV infection during the epidemic period. Risk factors for CHIKV seropositivity among adults (aged 15 years and older) were male gender, low socioeconomic index, schooling < or = 6 years and living in makeshift housing.<h4>Conclusions</h4>Our findings indicate that roughly one out of four CHIKV infections is asymptomatic. Conditions associated with poverty may be considered as critical in CHIKV acquisition. Thus, these conditions should be taken into account in the development of future prevention strategies of CHIKV disease.Daouda SissokoAmrat MoendandzeDenis MalvyClaude GiryKhaled EzzedineJean Louis SoletVincent PierrePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 8, p e3066 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daouda Sissoko Amrat Moendandze Denis Malvy Claude Giry Khaled Ezzedine Jean Louis Solet Vincent Pierre Seroprevalence and risk factors of chikungunya virus infection in Mayotte, Indian Ocean, 2005-2006: a population-based survey.
description	<h4>Background</h4>Since 2006, Chikungunya virus (CHIKV) has re-emerged as an important pathogen of global concern. However, individual and household factors associated with the acquisition and the magnitude of clinically silent CHIKV infections remain poorly understood. In this present study, we aimed to investigate the seroprevalence, estimate the proportion of symptomatic illness and identify the risk factors for CHIKV infection in the primo-exposed population of Mayotte. METHODS/ PRINCIPAL FINDINGS: We conducted a household-based cross sectional serosurvey in Mayotte in November and December 2006 using complex multistage cluster sampling. To produce the results representative of the island population aged 2 years or older, sample data were adjusted with sample weights. Explanatory and multiple logistic regression analyses were performed to investigate associations between CHIKV infection seropositivity (presence of IgM and/or IgG to CHIKV by enzyme-linked immunoabsorbent assay) and risk factors. A total of 1154 individuals were analyzed. The overall seroprevalence of CHIKV infection was 37.2% (95% CI = 33.9-40.5), 318 (72.3%) of the seropositive participants reported symptoms consistent with a CHIKV infection during the epidemic period. Risk factors for CHIKV seropositivity among adults (aged 15 years and older) were male gender, low socioeconomic index, schooling < or = 6 years and living in makeshift housing.<h4>Conclusions</h4>Our findings indicate that roughly one out of four CHIKV infections is asymptomatic. Conditions associated with poverty may be considered as critical in CHIKV acquisition. Thus, these conditions should be taken into account in the development of future prevention strategies of CHIKV disease.
format	article
author	Daouda Sissoko Amrat Moendandze Denis Malvy Claude Giry Khaled Ezzedine Jean Louis Solet Vincent Pierre
author_facet	Daouda Sissoko Amrat Moendandze Denis Malvy Claude Giry Khaled Ezzedine Jean Louis Solet Vincent Pierre
author_sort	Daouda Sissoko
title	Seroprevalence and risk factors of chikungunya virus infection in Mayotte, Indian Ocean, 2005-2006: a population-based survey.
title_short	Seroprevalence and risk factors of chikungunya virus infection in Mayotte, Indian Ocean, 2005-2006: a population-based survey.
title_full	Seroprevalence and risk factors of chikungunya virus infection in Mayotte, Indian Ocean, 2005-2006: a population-based survey.
title_fullStr	Seroprevalence and risk factors of chikungunya virus infection in Mayotte, Indian Ocean, 2005-2006: a population-based survey.
title_full_unstemmed	Seroprevalence and risk factors of chikungunya virus infection in Mayotte, Indian Ocean, 2005-2006: a population-based survey.
title_sort	seroprevalence and risk factors of chikungunya virus infection in mayotte, indian ocean, 2005-2006: a population-based survey.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/f08c1b3acddf4d8198ee80953a58b91f
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Seroprevalence and risk factors of chikungunya virus infection in Mayotte, Indian Ocean, 2005-2006: a population-based survey.

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