Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

New dietary approaches for the prevention of cognitive impairment are being investigated. However, evidence from dietary interventions is mainly from food and nutrient supplement interventions, with inconsistent results and high heterogeneity between trials. We conducted a comprehensive systematic s...

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Autores principales:	Laia Gutierrez, Alexandre Folch, Melina Rojas, José Luis Cantero, Mercedes Atienza, Jaume Folch, Antoni Camins, Agustín Ruiz, Christopher Papandreou, Mònica Bulló
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diet food supplements dietary interventions cognitive impairment healthy Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/f08c3b680e33452493a889e14c18299a
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spelling	oai:doaj.org-article:f08c3b680e33452493a889e14c18299a2021-11-25T18:33:33ZEffects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials10.3390/nu131137282072-6643https://doaj.org/article/f08c3b680e33452493a889e14c18299a2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3728https://doaj.org/toc/2072-6643New dietary approaches for the prevention of cognitive impairment are being investigated. However, evidence from dietary interventions is mainly from food and nutrient supplement interventions, with inconsistent results and high heterogeneity between trials. We conducted a comprehensive systematic search of randomized controlled trials (RCTs) published in MEDLINE-PubMed, from January 2018 to July 2021, investigating the impact of dietary counseling, as well as food-based and dietary supplement interventions on cognitive function in adults with or without cognitive impairment. Based on the search strategy, 197 eligible publications were used for data abstraction. Finally, 61 articles were included in the analysis. There was reasonable evidence that dietary patterns, as well as food and dietary supplements improved cognitive domains or measures of brain integrity. The Mediterranean diet showed promising results, whereas the role of the DASH diet was not clear. Healthy food consumption improved cognitive function, although the quality of these studies was relatively low. The role of dietary supplements was mixed, with strong evidence of the benefits of polyphenols and combinations of nutrients, but with low evidence for PUFAs, vitamin D, specific protein, amino acids, and other types of supplements. Further well-designed RCTs are needed to guide the development of dietary approaches for the prevention of cognitive impairment.Laia GutierrezAlexandre FolchMelina RojasJosé Luis CanteroMercedes AtienzaJaume FolchAntoni CaminsAgustín RuizChristopher PapandreouMònica BullóMDPI AGarticledietfoodsupplementsdietary interventionscognitive impairmenthealthyNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3728, p 3728 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diet food supplements dietary interventions cognitive impairment healthy Nutrition. Foods and food supply TX341-641
spellingShingle	diet food supplements dietary interventions cognitive impairment healthy Nutrition. Foods and food supply TX341-641 Laia Gutierrez Alexandre Folch Melina Rojas José Luis Cantero Mercedes Atienza Jaume Folch Antoni Camins Agustín Ruiz Christopher Papandreou Mònica Bulló Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials
description	New dietary approaches for the prevention of cognitive impairment are being investigated. However, evidence from dietary interventions is mainly from food and nutrient supplement interventions, with inconsistent results and high heterogeneity between trials. We conducted a comprehensive systematic search of randomized controlled trials (RCTs) published in MEDLINE-PubMed, from January 2018 to July 2021, investigating the impact of dietary counseling, as well as food-based and dietary supplement interventions on cognitive function in adults with or without cognitive impairment. Based on the search strategy, 197 eligible publications were used for data abstraction. Finally, 61 articles were included in the analysis. There was reasonable evidence that dietary patterns, as well as food and dietary supplements improved cognitive domains or measures of brain integrity. The Mediterranean diet showed promising results, whereas the role of the DASH diet was not clear. Healthy food consumption improved cognitive function, although the quality of these studies was relatively low. The role of dietary supplements was mixed, with strong evidence of the benefits of polyphenols and combinations of nutrients, but with low evidence for PUFAs, vitamin D, specific protein, amino acids, and other types of supplements. Further well-designed RCTs are needed to guide the development of dietary approaches for the prevention of cognitive impairment.
format	article
author	Laia Gutierrez Alexandre Folch Melina Rojas José Luis Cantero Mercedes Atienza Jaume Folch Antoni Camins Agustín Ruiz Christopher Papandreou Mònica Bulló
author_facet	Laia Gutierrez Alexandre Folch Melina Rojas José Luis Cantero Mercedes Atienza Jaume Folch Antoni Camins Agustín Ruiz Christopher Papandreou Mònica Bulló
author_sort	Laia Gutierrez
title	Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials
title_short	Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials
title_full	Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials
title_fullStr	Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials
title_full_unstemmed	Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials
title_sort	effects of nutrition on cognitive function in adults with or without cognitive impairment: a systematic review of randomized controlled clinical trials
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f08c3b680e33452493a889e14c18299a
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Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials

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