Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

The interplay between non-vesicular lipid transport, calcium signaling, and membrane dynamics is unclear. Here, the authors report a function for inositol triphosphate hydrolysis by the inositol 5-phosphatase INPP5A in controlling lipid exchange at interorganelle membrane contact sites between the e...

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Auteurs principaux:	Mouhannad Malek, Anna M. Wawrzyniak, Peter Koch, Christian Lüchtenborg, Manuel Hessenberger, Timo Sachsenheimer, Wonyul Jang, Britta Brügger, Volker Haucke
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f08d9ea9e2a840c19b61c37be2ec8fca
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spelling	oai:doaj.org-article:f08d9ea9e2a840c19b61c37be2ec8fca2021-12-02T17:01:35ZInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites10.1038/s41467-021-22882-x2041-1723https://doaj.org/article/f08d9ea9e2a840c19b61c37be2ec8fca2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22882-xhttps://doaj.org/toc/2041-1723The interplay between non-vesicular lipid transport, calcium signaling, and membrane dynamics is unclear. Here, the authors report a function for inositol triphosphate hydrolysis by the inositol 5-phosphatase INPP5A in controlling lipid exchange at interorganelle membrane contact sites between the endoplasmic reticulum and Golgi.Mouhannad MalekAnna M. WawrzyniakPeter KochChristian LüchtenborgManuel HessenbergerTimo SachsenheimerWonyul JangBritta BrüggerVolker HauckeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mouhannad Malek Anna M. Wawrzyniak Peter Koch Christian Lüchtenborg Manuel Hessenberger Timo Sachsenheimer Wonyul Jang Britta Brügger Volker Haucke Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
description	The interplay between non-vesicular lipid transport, calcium signaling, and membrane dynamics is unclear. Here, the authors report a function for inositol triphosphate hydrolysis by the inositol 5-phosphatase INPP5A in controlling lipid exchange at interorganelle membrane contact sites between the endoplasmic reticulum and Golgi.
format	article
author	Mouhannad Malek Anna M. Wawrzyniak Peter Koch Christian Lüchtenborg Manuel Hessenberger Timo Sachsenheimer Wonyul Jang Britta Brügger Volker Haucke
author_facet	Mouhannad Malek Anna M. Wawrzyniak Peter Koch Christian Lüchtenborg Manuel Hessenberger Timo Sachsenheimer Wonyul Jang Britta Brügger Volker Haucke
author_sort	Mouhannad Malek
title	Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
title_short	Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
title_full	Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
title_fullStr	Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
title_full_unstemmed	Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
title_sort	inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-golgi contact sites
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f08d9ea9e2a840c19b61c37be2ec8fca
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Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

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