Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites

The interplay between non-vesicular lipid transport, calcium signaling, and membrane dynamics is unclear. Here, the authors report a function for inositol triphosphate hydrolysis by the inositol 5-phosphatase INPP5A in controlling lipid exchange at interorganelle membrane contact sites between the e...

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Autores principales: Mouhannad Malek, Anna M. Wawrzyniak, Peter Koch, Christian Lüchtenborg, Manuel Hessenberger, Timo Sachsenheimer, Wonyul Jang, Britta Brügger, Volker Haucke
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f08d9ea9e2a840c19b61c37be2ec8fca
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spelling oai:doaj.org-article:f08d9ea9e2a840c19b61c37be2ec8fca2021-12-02T17:01:35ZInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites10.1038/s41467-021-22882-x2041-1723https://doaj.org/article/f08d9ea9e2a840c19b61c37be2ec8fca2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22882-xhttps://doaj.org/toc/2041-1723The interplay between non-vesicular lipid transport, calcium signaling, and membrane dynamics is unclear. Here, the authors report a function for inositol triphosphate hydrolysis by the inositol 5-phosphatase INPP5A in controlling lipid exchange at interorganelle membrane contact sites between the endoplasmic reticulum and Golgi.Mouhannad MalekAnna M. WawrzyniakPeter KochChristian LüchtenborgManuel HessenbergerTimo SachsenheimerWonyul JangBritta BrüggerVolker HauckeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mouhannad Malek
Anna M. Wawrzyniak
Peter Koch
Christian Lüchtenborg
Manuel Hessenberger
Timo Sachsenheimer
Wonyul Jang
Britta Brügger
Volker Haucke
Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
description The interplay between non-vesicular lipid transport, calcium signaling, and membrane dynamics is unclear. Here, the authors report a function for inositol triphosphate hydrolysis by the inositol 5-phosphatase INPP5A in controlling lipid exchange at interorganelle membrane contact sites between the endoplasmic reticulum and Golgi.
format article
author Mouhannad Malek
Anna M. Wawrzyniak
Peter Koch
Christian Lüchtenborg
Manuel Hessenberger
Timo Sachsenheimer
Wonyul Jang
Britta Brügger
Volker Haucke
author_facet Mouhannad Malek
Anna M. Wawrzyniak
Peter Koch
Christian Lüchtenborg
Manuel Hessenberger
Timo Sachsenheimer
Wonyul Jang
Britta Brügger
Volker Haucke
author_sort Mouhannad Malek
title Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
title_short Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
title_full Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
title_fullStr Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
title_full_unstemmed Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
title_sort inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-golgi contact sites
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f08d9ea9e2a840c19b61c37be2ec8fca
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