Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila

The role of mitochondrial DNA mutations in organismal fitness and lifespan have been studied in mitochondrial mutator models with varying results. Here, the authors generate a new APOBEC1 expression-based Drosophila mutator model and show that it has limited mitochondrial function and reduced lifesp...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Simonetta Andreazza, Colby L. Samstag, Alvaro Sanchez-Martinez, Erika Fernandez-Vizarra, Aurora Gomez-Duran, Juliette J. Lee, Roberta Tufi, Michael J. Hipp, Elizabeth K. Schmidt, Thomas J. Nicholls, Payam A. Gammage, Patrick F. Chinnery, Michal Minczuk, Leo J. Pallanck, Scott R. Kennedy, Alexander J. Whitworth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f090eaf1785247208a099d9f6a996bb3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f090eaf1785247208a099d9f6a996bb3
record_format	dspace
spelling	oai:doaj.org-article:f090eaf1785247208a099d9f6a996bb32021-12-02T16:57:46ZMitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila10.1038/s41467-019-10857-y2041-1723https://doaj.org/article/f090eaf1785247208a099d9f6a996bb32019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10857-yhttps://doaj.org/toc/2041-1723The role of mitochondrial DNA mutations in organismal fitness and lifespan have been studied in mitochondrial mutator models with varying results. Here, the authors generate a new APOBEC1 expression-based Drosophila mutator model and show that it has limited mitochondrial function and reduced lifespan.Simonetta AndreazzaColby L. SamstagAlvaro Sanchez-MartinezErika Fernandez-VizarraAurora Gomez-DuranJuliette J. LeeRoberta TufiMichael J. HippElizabeth K. SchmidtThomas J. NichollsPayam A. GammagePatrick F. ChinneryMichal MinczukLeo J. PallanckScott R. KennedyAlexander J. WhitworthNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simonetta Andreazza Colby L. Samstag Alvaro Sanchez-Martinez Erika Fernandez-Vizarra Aurora Gomez-Duran Juliette J. Lee Roberta Tufi Michael J. Hipp Elizabeth K. Schmidt Thomas J. Nicholls Payam A. Gammage Patrick F. Chinnery Michal Minczuk Leo J. Pallanck Scott R. Kennedy Alexander J. Whitworth Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
description	The role of mitochondrial DNA mutations in organismal fitness and lifespan have been studied in mitochondrial mutator models with varying results. Here, the authors generate a new APOBEC1 expression-based Drosophila mutator model and show that it has limited mitochondrial function and reduced lifespan.
format	article
author	Simonetta Andreazza Colby L. Samstag Alvaro Sanchez-Martinez Erika Fernandez-Vizarra Aurora Gomez-Duran Juliette J. Lee Roberta Tufi Michael J. Hipp Elizabeth K. Schmidt Thomas J. Nicholls Payam A. Gammage Patrick F. Chinnery Michal Minczuk Leo J. Pallanck Scott R. Kennedy Alexander J. Whitworth
author_facet	Simonetta Andreazza Colby L. Samstag Alvaro Sanchez-Martinez Erika Fernandez-Vizarra Aurora Gomez-Duran Juliette J. Lee Roberta Tufi Michael J. Hipp Elizabeth K. Schmidt Thomas J. Nicholls Payam A. Gammage Patrick F. Chinnery Michal Minczuk Leo J. Pallanck Scott R. Kennedy Alexander J. Whitworth
author_sort	Simonetta Andreazza
title	Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
title_short	Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
title_full	Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
title_fullStr	Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
title_full_unstemmed	Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
title_sort	mitochondrially-targeted apobec1 is a potent mtdna mutator affecting mitochondrial function and organismal fitness in drosophila
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f090eaf1785247208a099d9f6a996bb3
work_keys_str_mv	AT simonettaandreazza mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT colbylsamstag mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT alvarosanchezmartinez mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT erikafernandezvizarra mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT auroragomezduran mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT juliettejlee mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT robertatufi mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT michaeljhipp mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT elizabethkschmidt mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT thomasjnicholls mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT payamagammage mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT patrickfchinnery mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT michalminczuk mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT leojpallanck mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT scottrkennedy mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila AT alexanderjwhitworth mitochondriallytargetedapobec1isapotentmtdnamutatoraffectingmitochondrialfunctionandorganismalfitnessindrosophila
_version_	1718382481949851648

Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila

Ejemplares similares