Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection

Leukocyte function-associated antigen 1 (LFA-1) is the most widely expressed member of the β2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, its role in the response of CD8+ T cells to viral infections remains unclear. Inde...

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Autores principales:	Mario Perro, Matteo Iannacone, Ulrich H. von Andrian, Antonio Peixoto
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	integrin t cell activation lcmv t cell differentiation Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/f091faf694c34f37838f58697754d4a9
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spelling	oai:doaj.org-article:f091faf694c34f37838f58697754d4a92021-11-17T14:21:59ZRole of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection2150-55942150-560810.1080/21505594.2020.1845506https://doaj.org/article/f091faf694c34f37838f58697754d4a92020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1845506https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Leukocyte function-associated antigen 1 (LFA-1) is the most widely expressed member of the β2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, its role in the response of CD8+ T cells to viral infections remains unclear. Indeed, compelling clinical evidence shows that loss of LFA-1 function predisposes to infection in humans but animal models show limited to no susceptibility to infection. Here, we addressed this conundrum in a mouse model of infection with lymphocytic choriomeningitis virus (LCMV), where CD8+ T cells are necessary and sufficient to confer protection. To this end, we followed the fate and function of wild-type and LFA-1 deficient virus-specific CD8+ T cells and assessed the effect of blocking anti-LFA-1 monoclonal antibody in the outcome of infection. Our analysis of viral clearance and T cell responses using transcriptome profiling reveals a role for LFA-1 as a gatekeeper of effector T cell survival and dysfunction that when defective can predispose to LCMV infection.Mario PerroMatteo IannaconeUlrich H. von AndrianAntonio PeixotoTaylor & Francis Grouparticleintegrint cell activationlcmvt cell differentiationInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 1640-1655 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	integrin t cell activation lcmv t cell differentiation Infectious and parasitic diseases RC109-216
spellingShingle	integrin t cell activation lcmv t cell differentiation Infectious and parasitic diseases RC109-216 Mario Perro Matteo Iannacone Ulrich H. von Andrian Antonio Peixoto Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection
description	Leukocyte function-associated antigen 1 (LFA-1) is the most widely expressed member of the β2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, its role in the response of CD8+ T cells to viral infections remains unclear. Indeed, compelling clinical evidence shows that loss of LFA-1 function predisposes to infection in humans but animal models show limited to no susceptibility to infection. Here, we addressed this conundrum in a mouse model of infection with lymphocytic choriomeningitis virus (LCMV), where CD8+ T cells are necessary and sufficient to confer protection. To this end, we followed the fate and function of wild-type and LFA-1 deficient virus-specific CD8+ T cells and assessed the effect of blocking anti-LFA-1 monoclonal antibody in the outcome of infection. Our analysis of viral clearance and T cell responses using transcriptome profiling reveals a role for LFA-1 as a gatekeeper of effector T cell survival and dysfunction that when defective can predispose to LCMV infection.
format	article
author	Mario Perro Matteo Iannacone Ulrich H. von Andrian Antonio Peixoto
author_facet	Mario Perro Matteo Iannacone Ulrich H. von Andrian Antonio Peixoto
author_sort	Mario Perro
title	Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection
title_short	Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection
title_full	Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection
title_fullStr	Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection
title_full_unstemmed	Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection
title_sort	role of lfa-1 integrin in the control of a lymphocytic choriomeningitis virus (lcmv) infection
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/f091faf694c34f37838f58697754d4a9
work_keys_str_mv	AT marioperro roleoflfa1integrininthecontrolofalymphocyticchoriomeningitisviruslcmvinfection AT matteoiannacone roleoflfa1integrininthecontrolofalymphocyticchoriomeningitisviruslcmvinfection AT ulrichhvonandrian roleoflfa1integrininthecontrolofalymphocyticchoriomeningitisviruslcmvinfection AT antoniopeixoto roleoflfa1integrininthecontrolofalymphocyticchoriomeningitisviruslcmvinfection
_version_	1718425453887225856

Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection

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