Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies

Immediate treatment for cutaneous injuries is a realistic approach to improve the healing rate and minimise the risk of complications. Multifunctional biomaterials have been proven to be a potential strategy for chronic skin wound management, especially for future advancements in precision medicine....

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Autores principales:	Mazlan Zawani, Mh Busra Fauzi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	epigallocatechin gallate chronic skin wound antioxidants tissue engineering biomaterials reactive oxygen species Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/f0926aa608d940a5baa9b0cc914be147
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spelling	oai:doaj.org-article:f0926aa608d940a5baa9b0cc914be1472021-11-11T18:42:52ZEpigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies10.3390/polym132136562073-4360https://doaj.org/article/f0926aa608d940a5baa9b0cc914be1472021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/21/3656https://doaj.org/toc/2073-4360Immediate treatment for cutaneous injuries is a realistic approach to improve the healing rate and minimise the risk of complications. Multifunctional biomaterials have been proven to be a potential strategy for chronic skin wound management, especially for future advancements in precision medicine. Hence, antioxidant incorporated biomaterials play a vital role in the new era of tissue engineering. A bibliographic investigation was conducted on articles focusing on in vitro, in vivo, and clinical studies that evaluate the effect and the antioxidants mechanism exerted by epigallocatechin gallate (EGCG) in wound healing and its ability to act as reactive oxygen species (ROS) scavengers. Over the years, EGCG has been proven to be a potent antioxidant efficient for wound healing purposes. Therefore, several novel studies were included in this article to shed light on EGCG incorporated biomaterials over five years of research. However, the related papers under this review’s scope are limited in number. All the studies showed that biomaterials with scavenging ability have a great potential to combat chronic wounds and assist the wound healing process against oxidative damage. However, the promising concept has faced challenges extending beyond the trial phase, whereby the implementation of these biomaterials, when exposed to an oxidative stress environment, may disrupt cell proliferation and tissue regeneration after transplantation. Therefore, thorough research should be executed to ensure a successful therapy.Mazlan ZawaniMh Busra FauziMDPI AGarticleepigallocatechin gallatechronic skin woundantioxidantstissue engineeringbiomaterialsreactive oxygen speciesOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3656, p 3656 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epigallocatechin gallate chronic skin wound antioxidants tissue engineering biomaterials reactive oxygen species Organic chemistry QD241-441
spellingShingle	epigallocatechin gallate chronic skin wound antioxidants tissue engineering biomaterials reactive oxygen species Organic chemistry QD241-441 Mazlan Zawani Mh Busra Fauzi Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies
description	Immediate treatment for cutaneous injuries is a realistic approach to improve the healing rate and minimise the risk of complications. Multifunctional biomaterials have been proven to be a potential strategy for chronic skin wound management, especially for future advancements in precision medicine. Hence, antioxidant incorporated biomaterials play a vital role in the new era of tissue engineering. A bibliographic investigation was conducted on articles focusing on in vitro, in vivo, and clinical studies that evaluate the effect and the antioxidants mechanism exerted by epigallocatechin gallate (EGCG) in wound healing and its ability to act as reactive oxygen species (ROS) scavengers. Over the years, EGCG has been proven to be a potent antioxidant efficient for wound healing purposes. Therefore, several novel studies were included in this article to shed light on EGCG incorporated biomaterials over five years of research. However, the related papers under this review’s scope are limited in number. All the studies showed that biomaterials with scavenging ability have a great potential to combat chronic wounds and assist the wound healing process against oxidative damage. However, the promising concept has faced challenges extending beyond the trial phase, whereby the implementation of these biomaterials, when exposed to an oxidative stress environment, may disrupt cell proliferation and tissue regeneration after transplantation. Therefore, thorough research should be executed to ensure a successful therapy.
format	article
author	Mazlan Zawani Mh Busra Fauzi
author_facet	Mazlan Zawani Mh Busra Fauzi
author_sort	Mazlan Zawani
title	Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies
title_short	Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies
title_full	Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies
title_fullStr	Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies
title_full_unstemmed	Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies
title_sort	epigallocatechin gallate: the emerging wound healing potential of multifunctional biomaterials for future precision medicine treatment strategies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f0926aa608d940a5baa9b0cc914be147
work_keys_str_mv	AT mazlanzawani epigallocatechingallatetheemergingwoundhealingpotentialofmultifunctionalbiomaterialsforfutureprecisionmedicinetreatmentstrategies AT mhbusrafauzi epigallocatechingallatetheemergingwoundhealingpotentialofmultifunctionalbiomaterialsforfutureprecisionmedicinetreatmentstrategies
_version_	1718431797787754496

Epigallocatechin Gallate: The Emerging Wound Healing Potential of Multifunctional Biomaterials for Future Precision Medicine Treatment Strategies

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