Upper limits of normal for serum alanine aminotransferase levels in Chinese Han population.

<h4>Background and objectives</h4>Serum alanine aminotransferase (ALT) activity is the most common tool for the assessment of liver diseases. However, it is not clear whether the current normal ALT range really discriminate patients with or without liver diseases. The present study was t...

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Autores principales:	Ming-Hua Zheng, Ke-Qing Shi, Yu-Chen Fan, Wen-Yue Liu, Xian-Feng Lin, Ling-Fei Li, Yong-Ping Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f0949d104e79420993b3605baaa24211
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spelling	oai:doaj.org-article:f0949d104e79420993b3605baaa242112021-11-18T07:06:45ZUpper limits of normal for serum alanine aminotransferase levels in Chinese Han population.1932-620310.1371/journal.pone.0043736https://doaj.org/article/f0949d104e79420993b3605baaa242112012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22962588/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and objectives</h4>Serum alanine aminotransferase (ALT) activity is the most common tool for the assessment of liver diseases. However, it is not clear whether the current normal ALT range really discriminate patients with or without liver diseases. The present study was to establish a new normal range of ALT and examine its ability to identify patients with hepatitis B or nonalcoholic fatty liver disease (NAFLD) in Chinese Han population.<h4>Methods</h4>53037 adults were included in this study from January 1st 2008 to August 31st 2010. The 95th percentile of ALT in population with relative low risk factors for liver diseases was set as the new upper limits of normal ALT in gender-specific manner.<h4>Results</h4>The 95(th) percentile levels at low risk factors for liver diseases were achieved at 35 U/L for men and 23 U/L for women. The concordance statistics for detection were 0.873 (95%CI: 0.865-0.881) for HBV and 0.932 (95%CI: 0.927-0.937) for NAFLD in men while 0.857 (95%CI: 0.850-0.864) for HBV and 0.909 (95%CI: 0.903-0.915) for NAFLD in women. The median sensitivity of the current used ALT upper limit (40 U/L) was 6.6% for HBV and 29.7% for NAFLD and median specificity was 98.7% for men and 99.4% for women. Using our new-derived thresholds, the sensitivities ranged from 35.3% to 61.1% and the specificities were 94.8% for men and 94.6% for women.<h4>Conclusions</h4>Our results suggest that upper limits of ALT 35 U/L for men and 23 U/L for women in Chinese Han population. Re-consideration of normal limits of ALT should be recommended.<h4>Trial registration</h4>ChiCTR.org ChiCTR-OCS-11001173.Ming-Hua ZhengKe-Qing ShiYu-Chen FanWen-Yue LiuXian-Feng LinLing-Fei LiYong-Ping ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e43736 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ming-Hua Zheng Ke-Qing Shi Yu-Chen Fan Wen-Yue Liu Xian-Feng Lin Ling-Fei Li Yong-Ping Chen Upper limits of normal for serum alanine aminotransferase levels in Chinese Han population.
description	<h4>Background and objectives</h4>Serum alanine aminotransferase (ALT) activity is the most common tool for the assessment of liver diseases. However, it is not clear whether the current normal ALT range really discriminate patients with or without liver diseases. The present study was to establish a new normal range of ALT and examine its ability to identify patients with hepatitis B or nonalcoholic fatty liver disease (NAFLD) in Chinese Han population.<h4>Methods</h4>53037 adults were included in this study from January 1st 2008 to August 31st 2010. The 95th percentile of ALT in population with relative low risk factors for liver diseases was set as the new upper limits of normal ALT in gender-specific manner.<h4>Results</h4>The 95(th) percentile levels at low risk factors for liver diseases were achieved at 35 U/L for men and 23 U/L for women. The concordance statistics for detection were 0.873 (95%CI: 0.865-0.881) for HBV and 0.932 (95%CI: 0.927-0.937) for NAFLD in men while 0.857 (95%CI: 0.850-0.864) for HBV and 0.909 (95%CI: 0.903-0.915) for NAFLD in women. The median sensitivity of the current used ALT upper limit (40 U/L) was 6.6% for HBV and 29.7% for NAFLD and median specificity was 98.7% for men and 99.4% for women. Using our new-derived thresholds, the sensitivities ranged from 35.3% to 61.1% and the specificities were 94.8% for men and 94.6% for women.<h4>Conclusions</h4>Our results suggest that upper limits of ALT 35 U/L for men and 23 U/L for women in Chinese Han population. Re-consideration of normal limits of ALT should be recommended.<h4>Trial registration</h4>ChiCTR.org ChiCTR-OCS-11001173.
format	article
author	Ming-Hua Zheng Ke-Qing Shi Yu-Chen Fan Wen-Yue Liu Xian-Feng Lin Ling-Fei Li Yong-Ping Chen
author_facet	Ming-Hua Zheng Ke-Qing Shi Yu-Chen Fan Wen-Yue Liu Xian-Feng Lin Ling-Fei Li Yong-Ping Chen
author_sort	Ming-Hua Zheng
title	Upper limits of normal for serum alanine aminotransferase levels in Chinese Han population.
title_short	Upper limits of normal for serum alanine aminotransferase levels in Chinese Han population.
title_full	Upper limits of normal for serum alanine aminotransferase levels in Chinese Han population.
title_fullStr	Upper limits of normal for serum alanine aminotransferase levels in Chinese Han population.
title_full_unstemmed	Upper limits of normal for serum alanine aminotransferase levels in Chinese Han population.
title_sort	upper limits of normal for serum alanine aminotransferase levels in chinese han population.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/f0949d104e79420993b3605baaa24211
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Upper limits of normal for serum alanine aminotransferase levels in Chinese Han population.

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