Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome

Kang, Park and colleagues develop and demonstrate the effects of a new drug candidate for treatment of Hutchinson-Gilford progeria syndrome pathologies. Progerinin extends the life span of mice used to model this disease and induces histological and physiological improvements.

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Autores principales:	So-mi Kang, Min-Ho Yoon, Jinsook Ahn, Ji-Eun Kim, So Young Kim, Seock Yong Kang, Jeongmin Joo, Soyoung Park, Jung-Hyun Cho, Tae-Gyun Woo, Ah-Young Oh, Kyu Jin Chung, So Yon An, Tae Sung Hwang, Soo Yong Lee, Jeong-Su Kim, Nam-Chul Ha, Gyu-Yong Song, Bum-Joon Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f096a2f1eb914af38e3c04e0baf1efeb
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spelling	oai:doaj.org-article:f096a2f1eb914af38e3c04e0baf1efeb2021-12-02T11:45:59ZProgerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome10.1038/s42003-020-01540-w2399-3642https://doaj.org/article/f096a2f1eb914af38e3c04e0baf1efeb2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01540-whttps://doaj.org/toc/2399-3642Kang, Park and colleagues develop and demonstrate the effects of a new drug candidate for treatment of Hutchinson-Gilford progeria syndrome pathologies. Progerinin extends the life span of mice used to model this disease and induces histological and physiological improvements.So-mi KangMin-Ho YoonJinsook AhnJi-Eun KimSo Young KimSeock Yong KangJeongmin JooSoyoung ParkJung-Hyun ChoTae-Gyun WooAh-Young OhKyu Jin ChungSo Yon AnTae Sung HwangSoo Yong LeeJeong-Su KimNam-Chul HaGyu-Yong SongBum-Joon ParkNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 So-mi Kang Min-Ho Yoon Jinsook Ahn Ji-Eun Kim So Young Kim Seock Yong Kang Jeongmin Joo Soyoung Park Jung-Hyun Cho Tae-Gyun Woo Ah-Young Oh Kyu Jin Chung So Yon An Tae Sung Hwang Soo Yong Lee Jeong-Su Kim Nam-Chul Ha Gyu-Yong Song Bum-Joon Park Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome
description	Kang, Park and colleagues develop and demonstrate the effects of a new drug candidate for treatment of Hutchinson-Gilford progeria syndrome pathologies. Progerinin extends the life span of mice used to model this disease and induces histological and physiological improvements.
format	article
author	So-mi Kang Min-Ho Yoon Jinsook Ahn Ji-Eun Kim So Young Kim Seock Yong Kang Jeongmin Joo Soyoung Park Jung-Hyun Cho Tae-Gyun Woo Ah-Young Oh Kyu Jin Chung So Yon An Tae Sung Hwang Soo Yong Lee Jeong-Su Kim Nam-Chul Ha Gyu-Yong Song Bum-Joon Park
author_facet	So-mi Kang Min-Ho Yoon Jinsook Ahn Ji-Eun Kim So Young Kim Seock Yong Kang Jeongmin Joo Soyoung Park Jung-Hyun Cho Tae-Gyun Woo Ah-Young Oh Kyu Jin Chung So Yon An Tae Sung Hwang Soo Yong Lee Jeong-Su Kim Nam-Chul Ha Gyu-Yong Song Bum-Joon Park
author_sort	So-mi Kang
title	Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome
title_short	Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome
title_full	Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome
title_fullStr	Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome
title_full_unstemmed	Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome
title_sort	progerinin, an optimized progerin-lamin a binding inhibitor, ameliorates premature senescence phenotypes of hutchinson-gilford progeria syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f096a2f1eb914af38e3c04e0baf1efeb
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Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome

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