A Genome-Wide Association Study of a Korean Population Identifies Genetic Susceptibility to Hypertension Based on Sex-Specific Differences

Genome-wide association studies have expanded our understanding of the genetic variation of hypertension. Hypertension and blood pressure are influenced by sex-specific differences; therefore, genetic variants may have sex-specific effects on phenotype. To identify the genetic factors influencing th...

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Autores principales:	Seong-Beom Cho, Jinhwa Jang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hypertension sex genome-wide association study genetic effect heterogeneity Genetics QH426-470
Acceso en línea:	https://doaj.org/article/f097af67aaca4b278489d33fbeb57616
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spelling	oai:doaj.org-article:f097af67aaca4b278489d33fbeb576162021-11-25T17:42:11ZA Genome-Wide Association Study of a Korean Population Identifies Genetic Susceptibility to Hypertension Based on Sex-Specific Differences10.3390/genes121118042073-4425https://doaj.org/article/f097af67aaca4b278489d33fbeb576162021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1804https://doaj.org/toc/2073-4425Genome-wide association studies have expanded our understanding of the genetic variation of hypertension. Hypertension and blood pressure are influenced by sex-specific differences; therefore, genetic variants may have sex-specific effects on phenotype. To identify the genetic factors influencing the sex-specific differences concerning hypertension, we conducted a heterogeneity analysis of a genome-wide association study (GWAS) on 13,926 samples from a Korean population. Using the Illumina exome chip data of the population, we performed GWASs of the male and female population independently and applied a statistical test that identified heterogeneous effects of the variants between the two groups. To gain information about the biological implication of the genetic heterogeneity, we used gene set enrichment analysis with GWAS catalog and pathway gene sets. The heterogeneity analysis revealed that the rs11066015 of ACAD10 was a significant locus that had sex-specific genetic effects on the development of hypertension. The rs2074356 of HECTD4 also showed significant genetic heterogeneity in systolic blood pressure. The enrichment analysis showed significant results that are consistent with the pathophysiology of hypertension. These results indicate a sex-specific genetic susceptibility to hypertension that should be considered in future genetic studies of hypertension.Seong-Beom ChoJinhwa JangMDPI AGarticlehypertensionsexgenome-wide association studygenetic effectheterogeneityGeneticsQH426-470ENGenes, Vol 12, Iss 1804, p 1804 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypertension sex genome-wide association study genetic effect heterogeneity Genetics QH426-470
spellingShingle	hypertension sex genome-wide association study genetic effect heterogeneity Genetics QH426-470 Seong-Beom Cho Jinhwa Jang A Genome-Wide Association Study of a Korean Population Identifies Genetic Susceptibility to Hypertension Based on Sex-Specific Differences
description	Genome-wide association studies have expanded our understanding of the genetic variation of hypertension. Hypertension and blood pressure are influenced by sex-specific differences; therefore, genetic variants may have sex-specific effects on phenotype. To identify the genetic factors influencing the sex-specific differences concerning hypertension, we conducted a heterogeneity analysis of a genome-wide association study (GWAS) on 13,926 samples from a Korean population. Using the Illumina exome chip data of the population, we performed GWASs of the male and female population independently and applied a statistical test that identified heterogeneous effects of the variants between the two groups. To gain information about the biological implication of the genetic heterogeneity, we used gene set enrichment analysis with GWAS catalog and pathway gene sets. The heterogeneity analysis revealed that the rs11066015 of ACAD10 was a significant locus that had sex-specific genetic effects on the development of hypertension. The rs2074356 of HECTD4 also showed significant genetic heterogeneity in systolic blood pressure. The enrichment analysis showed significant results that are consistent with the pathophysiology of hypertension. These results indicate a sex-specific genetic susceptibility to hypertension that should be considered in future genetic studies of hypertension.
format	article
author	Seong-Beom Cho Jinhwa Jang
author_facet	Seong-Beom Cho Jinhwa Jang
author_sort	Seong-Beom Cho
title	A Genome-Wide Association Study of a Korean Population Identifies Genetic Susceptibility to Hypertension Based on Sex-Specific Differences
title_short	A Genome-Wide Association Study of a Korean Population Identifies Genetic Susceptibility to Hypertension Based on Sex-Specific Differences
title_full	A Genome-Wide Association Study of a Korean Population Identifies Genetic Susceptibility to Hypertension Based on Sex-Specific Differences
title_fullStr	A Genome-Wide Association Study of a Korean Population Identifies Genetic Susceptibility to Hypertension Based on Sex-Specific Differences
title_full_unstemmed	A Genome-Wide Association Study of a Korean Population Identifies Genetic Susceptibility to Hypertension Based on Sex-Specific Differences
title_sort	genome-wide association study of a korean population identifies genetic susceptibility to hypertension based on sex-specific differences
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f097af67aaca4b278489d33fbeb57616
work_keys_str_mv	AT seongbeomcho agenomewideassociationstudyofakoreanpopulationidentifiesgeneticsusceptibilitytohypertensionbasedonsexspecificdifferences AT jinhwajang agenomewideassociationstudyofakoreanpopulationidentifiesgeneticsusceptibilitytohypertensionbasedonsexspecificdifferences AT seongbeomcho genomewideassociationstudyofakoreanpopulationidentifiesgeneticsusceptibilitytohypertensionbasedonsexspecificdifferences AT jinhwajang genomewideassociationstudyofakoreanpopulationidentifiesgeneticsusceptibilitytohypertensionbasedonsexspecificdifferences
_version_	1718412140500484096

A Genome-Wide Association Study of a Korean Population Identifies Genetic Susceptibility to Hypertension Based on Sex-Specific Differences

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