Dissipation Dynamics, Terminal Residues and Dietary Risk Assessment of Two Isomers of Dimethacarb in Rice by HPLC-MS/MS

Dimethacarb is a carbamate insecticide developed in China that contains 3,5-dimethylphenyl methylcarbamate (XMC) and 3,4-dimethylphenyl methylcarbamate (MPMC) isomers. Dimethacarb has been registered for use in rice in China, but no residue or degradation of dimethacarb in rice has been reported and...

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Autores principales:	Shouying Tang, Xiurou Meng, Yongkang Wang, Xueqin Shi, Tianyou Feng, Deyu Hu, Yuping Zhang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dimethacarb rice degradation residues risk assessment HPLC-MS/MS Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/f097c9789fe247a6a245b28ae97baa40
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spelling	oai:doaj.org-article:f097c9789fe247a6a245b28ae97baa402021-11-25T17:33:22ZDissipation Dynamics, Terminal Residues and Dietary Risk Assessment of Two Isomers of Dimethacarb in Rice by HPLC-MS/MS10.3390/foods101126152304-8158https://doaj.org/article/f097c9789fe247a6a245b28ae97baa402021-10-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2615https://doaj.org/toc/2304-8158Dimethacarb is a carbamate insecticide developed in China that contains 3,5-dimethylphenyl methylcarbamate (XMC) and 3,4-dimethylphenyl methylcarbamate (MPMC) isomers. Dimethacarb has been registered for use in rice in China, but no residue or degradation of dimethacarb in rice has been reported and the maximum residue limits (MRLs) for rice have not been established. A versatile high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed with modified QuEChERS sample preparation to determine two isomers of dimethacarb in rice. The average recovery of XMC and MPMC in brown rice, rice husk, and rice straw ranged from 71.69 to 100.60%, with spike levels of 0.01 to 1 mg/kg and relative standard deviations (RSDs) of 0.21 to 8.41%. Field experiments showed that the half-lives of XMC and MPMC in rice straw were 4.08 to 4.23 days and 3.48 to 3.69 days, respectively. Final residues of XMC and MPMC in rice husk after 21 days of spraying at six sites ranged from 0.23–2.65 mg/kg and 0.06–1.10 mg/kg, and <0.01–0.16 mg/kg and <0.01–0.04 mg/kg in brown rice. The ratio of XMC to MPMC content in the rice husk differed from the original 50% dimethacarb EC, indicating the difference in the degradation rate of XMC and MPMC. The estimated risk quotient (RQ) for both XMC and MPMC was less than 30%. These data for residues from six representative locations could provide a reference for establishing the MRL of dimethacarb in rice.Shouying TangXiurou MengYongkang WangXueqin ShiTianyou FengDeyu HuYuping ZhangMDPI AGarticledimethacarbricedegradationresiduesrisk assessmentHPLC-MS/MSChemical technologyTP1-1185ENFoods, Vol 10, Iss 2615, p 2615 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dimethacarb rice degradation residues risk assessment HPLC-MS/MS Chemical technology TP1-1185
spellingShingle	dimethacarb rice degradation residues risk assessment HPLC-MS/MS Chemical technology TP1-1185 Shouying Tang Xiurou Meng Yongkang Wang Xueqin Shi Tianyou Feng Deyu Hu Yuping Zhang Dissipation Dynamics, Terminal Residues and Dietary Risk Assessment of Two Isomers of Dimethacarb in Rice by HPLC-MS/MS
description	Dimethacarb is a carbamate insecticide developed in China that contains 3,5-dimethylphenyl methylcarbamate (XMC) and 3,4-dimethylphenyl methylcarbamate (MPMC) isomers. Dimethacarb has been registered for use in rice in China, but no residue or degradation of dimethacarb in rice has been reported and the maximum residue limits (MRLs) for rice have not been established. A versatile high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed with modified QuEChERS sample preparation to determine two isomers of dimethacarb in rice. The average recovery of XMC and MPMC in brown rice, rice husk, and rice straw ranged from 71.69 to 100.60%, with spike levels of 0.01 to 1 mg/kg and relative standard deviations (RSDs) of 0.21 to 8.41%. Field experiments showed that the half-lives of XMC and MPMC in rice straw were 4.08 to 4.23 days and 3.48 to 3.69 days, respectively. Final residues of XMC and MPMC in rice husk after 21 days of spraying at six sites ranged from 0.23–2.65 mg/kg and 0.06–1.10 mg/kg, and <0.01–0.16 mg/kg and <0.01–0.04 mg/kg in brown rice. The ratio of XMC to MPMC content in the rice husk differed from the original 50% dimethacarb EC, indicating the difference in the degradation rate of XMC and MPMC. The estimated risk quotient (RQ) for both XMC and MPMC was less than 30%. These data for residues from six representative locations could provide a reference for establishing the MRL of dimethacarb in rice.
format	article
author	Shouying Tang Xiurou Meng Yongkang Wang Xueqin Shi Tianyou Feng Deyu Hu Yuping Zhang
author_facet	Shouying Tang Xiurou Meng Yongkang Wang Xueqin Shi Tianyou Feng Deyu Hu Yuping Zhang
author_sort	Shouying Tang
title	Dissipation Dynamics, Terminal Residues and Dietary Risk Assessment of Two Isomers of Dimethacarb in Rice by HPLC-MS/MS
title_short	Dissipation Dynamics, Terminal Residues and Dietary Risk Assessment of Two Isomers of Dimethacarb in Rice by HPLC-MS/MS
title_full	Dissipation Dynamics, Terminal Residues and Dietary Risk Assessment of Two Isomers of Dimethacarb in Rice by HPLC-MS/MS
title_fullStr	Dissipation Dynamics, Terminal Residues and Dietary Risk Assessment of Two Isomers of Dimethacarb in Rice by HPLC-MS/MS
title_full_unstemmed	Dissipation Dynamics, Terminal Residues and Dietary Risk Assessment of Two Isomers of Dimethacarb in Rice by HPLC-MS/MS
title_sort	dissipation dynamics, terminal residues and dietary risk assessment of two isomers of dimethacarb in rice by hplc-ms/ms
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f097c9789fe247a6a245b28ae97baa40
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Dissipation Dynamics, Terminal Residues and Dietary Risk Assessment of Two Isomers of Dimethacarb in Rice by HPLC-MS/MS

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