Evaluating optic nerve diameter as a possible biomarker for disability in patients with multiple sclerosis

Noha Abo Koraysha,1 Nirmeen Kishk,1 Amr Hassan,1 Nehal M Samy El Gendy,2 Hatem S Shehata,1 Salsabil Abo Al-Azayem,1 Yasmine Shawki Kamal1 1Neurology Department, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt; 2Ophthalomology Department, Ka...

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Autores principales:	Koraysha NA, Kishk N, Hassan A, Samy El Gendy NM, Shehata HS, Al-Azayem SA, Kamal YS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	multiple sclerosis biomarker OCT transorbital sonography RNFL. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f099d24bb8434bbda63800272e8e6e18
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spelling	oai:doaj.org-article:f099d24bb8434bbda63800272e8e6e182021-12-02T02:31:55ZEvaluating optic nerve diameter as a possible biomarker for disability in patients with multiple sclerosis1178-2021https://doaj.org/article/f099d24bb8434bbda63800272e8e6e182019-09-01T00:00:00Zhttps://www.dovepress.com/evaluating-optic-nerve-diameter-as-a-possible-biomarker-for-disability-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Noha Abo Koraysha,1 Nirmeen Kishk,1 Amr Hassan,1 Nehal M Samy El Gendy,2 Hatem S Shehata,1 Salsabil Abo Al-Azayem,1 Yasmine Shawki Kamal1 1Neurology Department, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt; 2Ophthalomology Department, Kasr Al Ainy Hospital, Cairo University, Cairo, EgyptCorrespondence: Nehal M Samy El GendyOphthalomology Department, Kasr Al Ainy Hospital, Cairo University, 43th Gameat El Dewal Street, Cairo 12411, EgyptTel +20 100 108 5164Email Nehal.ElGendy@kasralainy.edu.egBackground and purpose: The development of new biomarkers for multiple sclerosis (MS) is of paramount importance to improve our ability to predict disease progression and disability. The aim of this study was to evaluate the potential role of the optic nerve diameter (OND) measured by ultrasonography as a biomarker of early disability in patients with relapsing-remitting multiple sclerosis (RRMS).Methods: Forty-nine RRMS patients, 23 with a history of optic neuritis (MS-ON) and 26 without a history of optic neuritis (MS N-ON), and 50 age- and sex-matched healthy control subjects were included in the study. The OND and optic nerve sheath diameter (ONSD) were measured by transorbital sonography (TOS), and the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) thicknesses were measured by optical coherence tomography (OCT) using the Optovue RTVue™ system (Optovue, Inc., Fremont, CA, USA).Results: There was no significant difference between the patient (whether ON or N-ON eyes) and control groups in either the OND (p=0.979) or the ONSD (p=0.911). However, patients with an expanded disability status scale (EDSS) score >2 had a significantly lower OND and RNFL thicknesses (p=0.014, p=0.010 respectively) than patients with an EDSS score ≤2. Statistical logistic regression revealed that OND was an independent predictor of EDSS>2 (p=0.044, OR =0.000, 95% CI=0.000–0.589).Conclusion: The OND, as measured by ultrasonography, could be potentially used as a biomarker for the detection of early disability in RRMS patients.Keywords: multiple sclerosis, biomarker, OCT, transorbital sonography, RNFLKoraysha NAKishk NHassan ASamy El Gendy NMShehata HSAl-Azayem SAKamal YSDove Medical Pressarticlemultiple sclerosisbiomarkerOCTtransorbital sonographyRNFL.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2571-2578 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosis biomarker OCT transorbital sonography RNFL. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	multiple sclerosis biomarker OCT transorbital sonography RNFL. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Koraysha NA Kishk N Hassan A Samy El Gendy NM Shehata HS Al-Azayem SA Kamal YS Evaluating optic nerve diameter as a possible biomarker for disability in patients with multiple sclerosis
description	Noha Abo Koraysha,1 Nirmeen Kishk,1 Amr Hassan,1 Nehal M Samy El Gendy,2 Hatem S Shehata,1 Salsabil Abo Al-Azayem,1 Yasmine Shawki Kamal1 1Neurology Department, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt; 2Ophthalomology Department, Kasr Al Ainy Hospital, Cairo University, Cairo, EgyptCorrespondence: Nehal M Samy El GendyOphthalomology Department, Kasr Al Ainy Hospital, Cairo University, 43th Gameat El Dewal Street, Cairo 12411, EgyptTel +20 100 108 5164Email Nehal.ElGendy@kasralainy.edu.egBackground and purpose: The development of new biomarkers for multiple sclerosis (MS) is of paramount importance to improve our ability to predict disease progression and disability. The aim of this study was to evaluate the potential role of the optic nerve diameter (OND) measured by ultrasonography as a biomarker of early disability in patients with relapsing-remitting multiple sclerosis (RRMS).Methods: Forty-nine RRMS patients, 23 with a history of optic neuritis (MS-ON) and 26 without a history of optic neuritis (MS N-ON), and 50 age- and sex-matched healthy control subjects were included in the study. The OND and optic nerve sheath diameter (ONSD) were measured by transorbital sonography (TOS), and the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) thicknesses were measured by optical coherence tomography (OCT) using the Optovue RTVue™ system (Optovue, Inc., Fremont, CA, USA).Results: There was no significant difference between the patient (whether ON or N-ON eyes) and control groups in either the OND (p=0.979) or the ONSD (p=0.911). However, patients with an expanded disability status scale (EDSS) score >2 had a significantly lower OND and RNFL thicknesses (p=0.014, p=0.010 respectively) than patients with an EDSS score ≤2. Statistical logistic regression revealed that OND was an independent predictor of EDSS>2 (p=0.044, OR =0.000, 95% CI=0.000–0.589).Conclusion: The OND, as measured by ultrasonography, could be potentially used as a biomarker for the detection of early disability in RRMS patients.Keywords: multiple sclerosis, biomarker, OCT, transorbital sonography, RNFL
format	article
author	Koraysha NA Kishk N Hassan A Samy El Gendy NM Shehata HS Al-Azayem SA Kamal YS
author_facet	Koraysha NA Kishk N Hassan A Samy El Gendy NM Shehata HS Al-Azayem SA Kamal YS
author_sort	Koraysha NA
title	Evaluating optic nerve diameter as a possible biomarker for disability in patients with multiple sclerosis
title_short	Evaluating optic nerve diameter as a possible biomarker for disability in patients with multiple sclerosis
title_full	Evaluating optic nerve diameter as a possible biomarker for disability in patients with multiple sclerosis
title_fullStr	Evaluating optic nerve diameter as a possible biomarker for disability in patients with multiple sclerosis
title_full_unstemmed	Evaluating optic nerve diameter as a possible biomarker for disability in patients with multiple sclerosis
title_sort	evaluating optic nerve diameter as a possible biomarker for disability in patients with multiple sclerosis
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f099d24bb8434bbda63800272e8e6e18
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Evaluating optic nerve diameter as a possible biomarker for disability in patients with multiple sclerosis

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