Histidine-rich glycoprotein as a prognostic biomarker for sepsis

Abstract Various biomarkers have been proposed for sepsis; however, only a few become the standard. We previously reported that plasma histidine-rich glycoprotein (HRG) levels decreased in septic mice, and supplemental infusion of HRG improved survival in mice model of sepsis. Moreover, our previous...

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Autores principales:	Kosuke Kuroda, Kenzo Ishii, Yuko Mihara, Naoya Kawanoue, Hidenori Wake, Shuji Mori, Michihiro Yoshida, Masahiro Nishibori, Hiroshi Morimatsu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f09f13e87665407ca0f8aca65649dc8f
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spelling	oai:doaj.org-article:f09f13e87665407ca0f8aca65649dc8f2021-12-02T16:50:27ZHistidine-rich glycoprotein as a prognostic biomarker for sepsis10.1038/s41598-021-89555-z2045-2322https://doaj.org/article/f09f13e87665407ca0f8aca65649dc8f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89555-zhttps://doaj.org/toc/2045-2322Abstract Various biomarkers have been proposed for sepsis; however, only a few become the standard. We previously reported that plasma histidine-rich glycoprotein (HRG) levels decreased in septic mice, and supplemental infusion of HRG improved survival in mice model of sepsis. Moreover, our previous clinical study demonstrated that HRG levels in septic patients were lower than those in noninfective systemic inflammatory response syndrome patients, and it could be a biomarker for sepsis. In this study, we focused on septic patients and assessed the differences in HRG levels between the non-survivors and survivors. We studied ICU patients newly diagnosed with sepsis. Blood samples were collected within 24 h of ICU admission, and HRG levels were determined using an enzyme-linked immunosorbent assay. Ninety-nine septic patients from 11 institutes in Japan were included. HRG levels were significantly lower in non-survivors (n = 16) than in survivors (n = 83) (median, 15.1 [interquartile ranges, 12.7–16.6] vs. 30.6 [22.1–39.6] µg/ml; p < 0.01). Survival analysis revealed that HRG levels were associated with mortality (hazard ratio 0.79, p < 0.01), and the Harrell C-index (predictive power) for HRG was 0.90. These results suggested that HRG could be a novel prognostic biomarker for sepsis.Kosuke KurodaKenzo IshiiYuko MiharaNaoya KawanoueHidenori WakeShuji MoriMichihiro YoshidaMasahiro NishiboriHiroshi MorimatsuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kosuke Kuroda Kenzo Ishii Yuko Mihara Naoya Kawanoue Hidenori Wake Shuji Mori Michihiro Yoshida Masahiro Nishibori Hiroshi Morimatsu Histidine-rich glycoprotein as a prognostic biomarker for sepsis
description	Abstract Various biomarkers have been proposed for sepsis; however, only a few become the standard. We previously reported that plasma histidine-rich glycoprotein (HRG) levels decreased in septic mice, and supplemental infusion of HRG improved survival in mice model of sepsis. Moreover, our previous clinical study demonstrated that HRG levels in septic patients were lower than those in noninfective systemic inflammatory response syndrome patients, and it could be a biomarker for sepsis. In this study, we focused on septic patients and assessed the differences in HRG levels between the non-survivors and survivors. We studied ICU patients newly diagnosed with sepsis. Blood samples were collected within 24 h of ICU admission, and HRG levels were determined using an enzyme-linked immunosorbent assay. Ninety-nine septic patients from 11 institutes in Japan were included. HRG levels were significantly lower in non-survivors (n = 16) than in survivors (n = 83) (median, 15.1 [interquartile ranges, 12.7–16.6] vs. 30.6 [22.1–39.6] µg/ml; p < 0.01). Survival analysis revealed that HRG levels were associated with mortality (hazard ratio 0.79, p < 0.01), and the Harrell C-index (predictive power) for HRG was 0.90. These results suggested that HRG could be a novel prognostic biomarker for sepsis.
format	article
author	Kosuke Kuroda Kenzo Ishii Yuko Mihara Naoya Kawanoue Hidenori Wake Shuji Mori Michihiro Yoshida Masahiro Nishibori Hiroshi Morimatsu
author_facet	Kosuke Kuroda Kenzo Ishii Yuko Mihara Naoya Kawanoue Hidenori Wake Shuji Mori Michihiro Yoshida Masahiro Nishibori Hiroshi Morimatsu
author_sort	Kosuke Kuroda
title	Histidine-rich glycoprotein as a prognostic biomarker for sepsis
title_short	Histidine-rich glycoprotein as a prognostic biomarker for sepsis
title_full	Histidine-rich glycoprotein as a prognostic biomarker for sepsis
title_fullStr	Histidine-rich glycoprotein as a prognostic biomarker for sepsis
title_full_unstemmed	Histidine-rich glycoprotein as a prognostic biomarker for sepsis
title_sort	histidine-rich glycoprotein as a prognostic biomarker for sepsis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f09f13e87665407ca0f8aca65649dc8f
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Histidine-rich glycoprotein as a prognostic biomarker for sepsis

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