Alterations of amplitude of low-frequency fluctuation in treatment-resistant versus non-treatment-resistant depression patients

Aixia Zhang,1,2 Gaizhi Li,1 Chunxia Yang,1 Penghong Liu,2 Yanfang Wang,1 Lijun Kang,2 Yuchen Wang,2 Kerang Zhang11Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, People’s Republic of China; 2Shanxi Medical University, Taiyuan 030001, People&a...

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Autores principales:	Zhang A, Li G, Yang C, Liu P, Wang Y, Kang L, Zhang K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	amplitude of low frequency fluctuation refractory depression 264 putative functional area Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f09f54ed79f54f00ab0ca2a28fd0dbec
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spelling	oai:doaj.org-article:f09f54ed79f54f00ab0ca2a28fd0dbec2021-12-02T11:18:22ZAlterations of amplitude of low-frequency fluctuation in treatment-resistant versus non-treatment-resistant depression patients1178-2021https://doaj.org/article/f09f54ed79f54f00ab0ca2a28fd0dbec2019-07-01T00:00:00Zhttps://www.dovepress.com/alterations-of-amplitude-of-low-frequency-fluctuation-in-treatment-res-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Aixia Zhang,1,2 Gaizhi Li,1 Chunxia Yang,1 Penghong Liu,2 Yanfang Wang,1 Lijun Kang,2 Yuchen Wang,2 Kerang Zhang11Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, People’s Republic of China; 2Shanxi Medical University, Taiyuan 030001, People’s Republic of ChinaPurpose: We used parcellation based on 264 putative functional areas to explore the difference of amplitude of low-frequency fluctuation (ALFF) between refractory depression and non-refractory depression patients.Patients and methods: Sixty first episode drug-naive patients with major depressive disorder (MDD) and 20 healthy controls (HCs) were recruited in this study; the MDD group was divided into a refractory depression (TRD) group (n=15) and a non-refractory depression (non-TRD) group (n=18) according to the treatment effect following up for 2 years. All the subjects underwent magnetic resonance imaging scanning and performed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and all the patients with MDD finished the 17-item Hamilton Depression Rating Scale (HAMD17). We used a parcellation based on 264 putative functional areas to explore the difference of ALFF measures in the three groups. The correlation between the abnormal ALFF value and characteristics of MDD was examined.Results: RBANS total scores and index scores in the HCs were significantly different from that of the MDD group. HAMD-17 in the TRD group was significantly higher than that of non-TRD group. Relative to HCs, MDD groups showed significantly lower ALFF within the right default mode network, which was positively correlated with the immediate memory and language in the MDD group. Compared with the non-TRD group, the TRD group showed higher ALFF in the right sensory/somatomotor hand, right auditory and left default mode network.Conclusion: Dysfunction of the somatosensory areas, right auditory and left default mode network may be a marker for specific psychopathology symptoms of TRD.Keywords: amplitude of low frequency fluctuation, refractory depression, 264 putative functional areaZhang ALi GYang CLiu PWang YKang LWang YZhang KDove Medical Pressarticleamplitude of low frequency fluctuationrefractory depression264 putative functional areaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2119-2128 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	amplitude of low frequency fluctuation refractory depression 264 putative functional area Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	amplitude of low frequency fluctuation refractory depression 264 putative functional area Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhang A Li G Yang C Liu P Wang Y Kang L Wang Y Zhang K Alterations of amplitude of low-frequency fluctuation in treatment-resistant versus non-treatment-resistant depression patients
description	Aixia Zhang,1,2 Gaizhi Li,1 Chunxia Yang,1 Penghong Liu,2 Yanfang Wang,1 Lijun Kang,2 Yuchen Wang,2 Kerang Zhang11Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, People’s Republic of China; 2Shanxi Medical University, Taiyuan 030001, People’s Republic of ChinaPurpose: We used parcellation based on 264 putative functional areas to explore the difference of amplitude of low-frequency fluctuation (ALFF) between refractory depression and non-refractory depression patients.Patients and methods: Sixty first episode drug-naive patients with major depressive disorder (MDD) and 20 healthy controls (HCs) were recruited in this study; the MDD group was divided into a refractory depression (TRD) group (n=15) and a non-refractory depression (non-TRD) group (n=18) according to the treatment effect following up for 2 years. All the subjects underwent magnetic resonance imaging scanning and performed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and all the patients with MDD finished the 17-item Hamilton Depression Rating Scale (HAMD17). We used a parcellation based on 264 putative functional areas to explore the difference of ALFF measures in the three groups. The correlation between the abnormal ALFF value and characteristics of MDD was examined.Results: RBANS total scores and index scores in the HCs were significantly different from that of the MDD group. HAMD-17 in the TRD group was significantly higher than that of non-TRD group. Relative to HCs, MDD groups showed significantly lower ALFF within the right default mode network, which was positively correlated with the immediate memory and language in the MDD group. Compared with the non-TRD group, the TRD group showed higher ALFF in the right sensory/somatomotor hand, right auditory and left default mode network.Conclusion: Dysfunction of the somatosensory areas, right auditory and left default mode network may be a marker for specific psychopathology symptoms of TRD.Keywords: amplitude of low frequency fluctuation, refractory depression, 264 putative functional area
format	article
author	Zhang A Li G Yang C Liu P Wang Y Kang L Wang Y Zhang K
author_facet	Zhang A Li G Yang C Liu P Wang Y Kang L Wang Y Zhang K
author_sort	Zhang A
title	Alterations of amplitude of low-frequency fluctuation in treatment-resistant versus non-treatment-resistant depression patients
title_short	Alterations of amplitude of low-frequency fluctuation in treatment-resistant versus non-treatment-resistant depression patients
title_full	Alterations of amplitude of low-frequency fluctuation in treatment-resistant versus non-treatment-resistant depression patients
title_fullStr	Alterations of amplitude of low-frequency fluctuation in treatment-resistant versus non-treatment-resistant depression patients
title_full_unstemmed	Alterations of amplitude of low-frequency fluctuation in treatment-resistant versus non-treatment-resistant depression patients
title_sort	alterations of amplitude of low-frequency fluctuation in treatment-resistant versus non-treatment-resistant depression patients
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f09f54ed79f54f00ab0ca2a28fd0dbec
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Alterations of amplitude of low-frequency fluctuation in treatment-resistant versus non-treatment-resistant depression patients

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