Osteopontin's relationship with malnutrition and oxidative stress in adolescents. A pilot study.

Osteopontin (OPN) is a protein involved in inflammatory illnesses such as fibrosis and cancer; its overexpression in cardiovascular diseases promotes the biomineralization of blood vessels and other soft tissues. Moreover, there is an active component of oxidative stress related with those diseases....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Octavio Gamaliel Aztatzi-Aguilar, Martha Patricia Sierra-Vargas, Manolo Ortega-Romero, Azucena Eunice Jiménez-Corona
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f0a0636d366942d2b0c56181c9b57633
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f0a0636d366942d2b0c56181c9b57633
record_format	dspace
spelling	oai:doaj.org-article:f0a0636d366942d2b0c56181c9b576332021-11-25T06:19:26ZOsteopontin's relationship with malnutrition and oxidative stress in adolescents. A pilot study.1932-620310.1371/journal.pone.0249057https://doaj.org/article/f0a0636d366942d2b0c56181c9b576332021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0249057https://doaj.org/toc/1932-6203Osteopontin (OPN) is a protein involved in inflammatory illnesses such as fibrosis and cancer; its overexpression in cardiovascular diseases promotes the biomineralization of blood vessels and other soft tissues. Moreover, there is an active component of oxidative stress related with those diseases. The present study relates serum OPN levels with nutritional condition and oxidative stress in a group of adolescents. Anthropometric measurements were performed, and fasting blood samples were analyzed to determine OPN concentrations, blood chemistry parameters (glucose, triglycerides, total cholesterol, urea, uric acid, and creatinine) and oxidative stress biomarkers (Paraoxonase-1, Glutathione S-Transferase, Catalase, NAD(P)H Quinone Oxidoreductase, free carbonyl groups and malondialdehyde). Adolescents were categorized according to body mass index (BMI) and metabolic syndrome (MetS) criteria. We found increased OPN serum concentrations in overweight and obese adolescents, as well as in adolescents with MetS. Rises in OPN correlated with arm circumference and biomarkers of lipid peroxidation; with regard to serum glucose there was a trend to positive correlation. Our results suggest that serum OPN is associated to nutritional status and could be considered as an early biomarker of low-grade inflammation and probably the early biomineralization of soft tissues in adolescence.Octavio Gamaliel Aztatzi-AguilarMartha Patricia Sierra-VargasManolo Ortega-RomeroAzucena Eunice Jiménez-CoronaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 3, p e0249057 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Octavio Gamaliel Aztatzi-Aguilar Martha Patricia Sierra-Vargas Manolo Ortega-Romero Azucena Eunice Jiménez-Corona Osteopontin's relationship with malnutrition and oxidative stress in adolescents. A pilot study.
description	Osteopontin (OPN) is a protein involved in inflammatory illnesses such as fibrosis and cancer; its overexpression in cardiovascular diseases promotes the biomineralization of blood vessels and other soft tissues. Moreover, there is an active component of oxidative stress related with those diseases. The present study relates serum OPN levels with nutritional condition and oxidative stress in a group of adolescents. Anthropometric measurements were performed, and fasting blood samples were analyzed to determine OPN concentrations, blood chemistry parameters (glucose, triglycerides, total cholesterol, urea, uric acid, and creatinine) and oxidative stress biomarkers (Paraoxonase-1, Glutathione S-Transferase, Catalase, NAD(P)H Quinone Oxidoreductase, free carbonyl groups and malondialdehyde). Adolescents were categorized according to body mass index (BMI) and metabolic syndrome (MetS) criteria. We found increased OPN serum concentrations in overweight and obese adolescents, as well as in adolescents with MetS. Rises in OPN correlated with arm circumference and biomarkers of lipid peroxidation; with regard to serum glucose there was a trend to positive correlation. Our results suggest that serum OPN is associated to nutritional status and could be considered as an early biomarker of low-grade inflammation and probably the early biomineralization of soft tissues in adolescence.
format	article
author	Octavio Gamaliel Aztatzi-Aguilar Martha Patricia Sierra-Vargas Manolo Ortega-Romero Azucena Eunice Jiménez-Corona
author_facet	Octavio Gamaliel Aztatzi-Aguilar Martha Patricia Sierra-Vargas Manolo Ortega-Romero Azucena Eunice Jiménez-Corona
author_sort	Octavio Gamaliel Aztatzi-Aguilar
title	Osteopontin's relationship with malnutrition and oxidative stress in adolescents. A pilot study.
title_short	Osteopontin's relationship with malnutrition and oxidative stress in adolescents. A pilot study.
title_full	Osteopontin's relationship with malnutrition and oxidative stress in adolescents. A pilot study.
title_fullStr	Osteopontin's relationship with malnutrition and oxidative stress in adolescents. A pilot study.
title_full_unstemmed	Osteopontin's relationship with malnutrition and oxidative stress in adolescents. A pilot study.
title_sort	osteopontin's relationship with malnutrition and oxidative stress in adolescents. a pilot study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f0a0636d366942d2b0c56181c9b57633
work_keys_str_mv	AT octaviogamalielaztatziaguilar osteopontinsrelationshipwithmalnutritionandoxidativestressinadolescentsapilotstudy AT marthapatriciasierravargas osteopontinsrelationshipwithmalnutritionandoxidativestressinadolescentsapilotstudy AT manoloortegaromero osteopontinsrelationshipwithmalnutritionandoxidativestressinadolescentsapilotstudy AT azucenaeunicejimenezcorona osteopontinsrelationshipwithmalnutritionandoxidativestressinadolescentsapilotstudy
_version_	1718413899888328704

Osteopontin's relationship with malnutrition and oxidative stress in adolescents. A pilot study.

Ejemplares similares