In vitro effect of terpenoid-rich extract of Momordica charantia on alpha glucosidase activity

Background: Momordica charantia is a vine, native to tropics and subtropics that has found use in herbal medicine. In Nigeria, the plant is locally used in the treatment of diabetes. Objective: To investigate the inhibitory effect of terpenoid-rich extract from Momordica charantia on α-glucosidase...

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Autores principales:	AB SALLAU, RN YAKUBU, SM ALIYU, A SALIHU, BY BONIFACE
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2018
Materias:	α-glucosidase terpenoids inhibitor inhibition hyperglycemia extract. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/f0a20c7f64a740a6be6c2531d4193b41
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spelling	oai:doaj.org-article:f0a20c7f64a740a6be6c2531d4193b412021-11-19T04:08:41ZIn vitro effect of terpenoid-rich extract of Momordica charantia on alpha glucosidase activity0121-40042145-2660https://doaj.org/article/f0a20c7f64a740a6be6c2531d4193b412018-12-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/331403https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 Background: Momordica charantia is a vine, native to tropics and subtropics that has found use in herbal medicine. In Nigeria, the plant is locally used in the treatment of diabetes. Objective: To investigate the inhibitory effect of terpenoid-rich extract from Momordica charantia on α-glucosidase activity. Method: The inhibitory effect of the terpenoid-rich extract from Momordica charantia on the activity of alpha-glucosidase from Saccharomyces cerevisiae as well as the determination of the mode of inhibition were investigated using in vitro assay methods. Results: The results revealed that the terpenoid-rich extract had a high IC50 of 1.60 mg/mL. The Lineweaver-Burk plot revealed that the extract exhibited partially mixed–type inhibition of α-glucosidase. Conclusions: It can be inferred from this study that although terpenoid-rich extract inhibited α- glucosidase, further purification will be necessary on the extract so as to increase its potency as an inhibitor of α-glucosidase. The action of the extract on α-glucosidase provided an insight into the probable mechanism of action of Momordica charantia in reducing hyperglycemia. AB SALLAURN YAKUBUSM ALIYUA SALIHUBY BONIFACEUniversidad de Antioquiaarticleα-glucosidaseterpenoidsinhibitorinhibitionhyperglycemiaextract.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 25, Iss 3 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	α-glucosidase terpenoids inhibitor inhibition hyperglycemia extract. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	α-glucosidase terpenoids inhibitor inhibition hyperglycemia extract. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 AB SALLAU RN YAKUBU SM ALIYU A SALIHU BY BONIFACE In vitro effect of terpenoid-rich extract of Momordica charantia on alpha glucosidase activity
description	Background: Momordica charantia is a vine, native to tropics and subtropics that has found use in herbal medicine. In Nigeria, the plant is locally used in the treatment of diabetes. Objective: To investigate the inhibitory effect of terpenoid-rich extract from Momordica charantia on α-glucosidase activity. Method: The inhibitory effect of the terpenoid-rich extract from Momordica charantia on the activity of alpha-glucosidase from Saccharomyces cerevisiae as well as the determination of the mode of inhibition were investigated using in vitro assay methods. Results: The results revealed that the terpenoid-rich extract had a high IC50 of 1.60 mg/mL. The Lineweaver-Burk plot revealed that the extract exhibited partially mixed–type inhibition of α-glucosidase. Conclusions: It can be inferred from this study that although terpenoid-rich extract inhibited α- glucosidase, further purification will be necessary on the extract so as to increase its potency as an inhibitor of α-glucosidase. The action of the extract on α-glucosidase provided an insight into the probable mechanism of action of Momordica charantia in reducing hyperglycemia.
format	article
author	AB SALLAU RN YAKUBU SM ALIYU A SALIHU BY BONIFACE
author_facet	AB SALLAU RN YAKUBU SM ALIYU A SALIHU BY BONIFACE
author_sort	AB SALLAU
title	In vitro effect of terpenoid-rich extract of Momordica charantia on alpha glucosidase activity
title_short	In vitro effect of terpenoid-rich extract of Momordica charantia on alpha glucosidase activity
title_full	In vitro effect of terpenoid-rich extract of Momordica charantia on alpha glucosidase activity
title_fullStr	In vitro effect of terpenoid-rich extract of Momordica charantia on alpha glucosidase activity
title_full_unstemmed	In vitro effect of terpenoid-rich extract of Momordica charantia on alpha glucosidase activity
title_sort	in vitro effect of terpenoid-rich extract of momordica charantia on alpha glucosidase activity
publisher	Universidad de Antioquia
publishDate	2018
url	https://doaj.org/article/f0a20c7f64a740a6be6c2531d4193b41
work_keys_str_mv	AT absallau invitroeffectofterpenoidrichextractofmomordicacharantiaonalphaglucosidaseactivity AT rnyakubu invitroeffectofterpenoidrichextractofmomordicacharantiaonalphaglucosidaseactivity AT smaliyu invitroeffectofterpenoidrichextractofmomordicacharantiaonalphaglucosidaseactivity AT asalihu invitroeffectofterpenoidrichextractofmomordicacharantiaonalphaglucosidaseactivity AT byboniface invitroeffectofterpenoidrichextractofmomordicacharantiaonalphaglucosidaseactivity
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In vitro effect of terpenoid-rich extract of Momordica charantia on alpha glucosidase activity

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