Optical coherence tomography parameters predictive of visual outcome after anti-VEGF therapy for retinal vein occlusion

Akiko Fujihara-Mino, Yoshinori Mitamura, Naoki Inomoto, Hiroki Sano, Kei Akaiwa, Kentaro Semba Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan Purpose: To determine the optical coherence tomography (OCT) parameters that are pred...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fujihara-Mino A, Mitamura Y, Inomoto N, Sano H, Akaiwa K, Semba K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	anti-vascular endothelial growth factor therapy retinal sensitivity retinal vein occlusion spectral-domain optical coherence tomography visual acuity Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f0a2d23f434c436bb0ae91ca162d610b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f0a2d23f434c436bb0ae91ca162d610b
record_format	dspace
spelling	oai:doaj.org-article:f0a2d23f434c436bb0ae91ca162d610b2021-12-02T02:03:02ZOptical coherence tomography parameters predictive of visual outcome after anti-VEGF therapy for retinal vein occlusion1177-5483https://doaj.org/article/f0a2d23f434c436bb0ae91ca162d610b2016-07-01T00:00:00Zhttps://www.dovepress.com/optical-coherence-tomography--parameters-predictive-of-visual-outcome--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Akiko Fujihara-Mino, Yoshinori Mitamura, Naoki Inomoto, Hiroki Sano, Kei Akaiwa, Kentaro Semba Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan Purpose: To determine the optical coherence tomography (OCT) parameters that are predictive of visual outcome after anti-VEGF therapy for a retinal vein occlusion (RVO). Methods: Fifty-seven eyes with macular edema (ME) secondary to a central or branch RVO treated with bevacizumab or ranibizumab were studied. Spectral-domain OCT and microperimetry were performed before, 1, 3, and 6 months after the treatment and at the final visit. Central retinal thickness (CRT), macular volume (MV), integrity of the external limiting membrane (ELM), ellipsoid zone (EZ), and foveal bulge (FB), and photoreceptor outer segment (PROS) length were determined. Results: The mean follow-up period was 17.8±11.5 months. In 46 of the 57 eyes, a resolution of the ME was achieved. The pretreatment CRT and MV, presence of intact ELM, EZ, and FB, and PROS length at the time of ME resolution were significantly correlated with the best-corrected visual acuity and retinal sensitivity at the final visit (P<0.050). Multiple regression analyses showed that the pretreatment MV had the highest correlation with the posttreatment best-corrected visual acuity and retinal sensitivity (P<0.050). Conclusion: The CRT, MV, ELM, EZ, FB, and PROS length are predictive factors for the visual outcome after anti-VEGF therapy for RVO. Keywords: anti-VEGF therapy, retinal sensitivity, retinal vein occlusion, spectral-domain optical coherence tomography, visual acuityFujihara-Mino AMitamura YInomoto NSano HAkaiwa KSemba KDove Medical Pressarticleanti-vascular endothelial growth factor therapyretinal sensitivityretinal vein occlusionspectral-domain optical coherence tomographyvisual acuityOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 1305-1313 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-vascular endothelial growth factor therapy retinal sensitivity retinal vein occlusion spectral-domain optical coherence tomography visual acuity Ophthalmology RE1-994
spellingShingle	anti-vascular endothelial growth factor therapy retinal sensitivity retinal vein occlusion spectral-domain optical coherence tomography visual acuity Ophthalmology RE1-994 Fujihara-Mino A Mitamura Y Inomoto N Sano H Akaiwa K Semba K Optical coherence tomography parameters predictive of visual outcome after anti-VEGF therapy for retinal vein occlusion
description	Akiko Fujihara-Mino, Yoshinori Mitamura, Naoki Inomoto, Hiroki Sano, Kei Akaiwa, Kentaro Semba Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan Purpose: To determine the optical coherence tomography (OCT) parameters that are predictive of visual outcome after anti-VEGF therapy for a retinal vein occlusion (RVO). Methods: Fifty-seven eyes with macular edema (ME) secondary to a central or branch RVO treated with bevacizumab or ranibizumab were studied. Spectral-domain OCT and microperimetry were performed before, 1, 3, and 6 months after the treatment and at the final visit. Central retinal thickness (CRT), macular volume (MV), integrity of the external limiting membrane (ELM), ellipsoid zone (EZ), and foveal bulge (FB), and photoreceptor outer segment (PROS) length were determined. Results: The mean follow-up period was 17.8±11.5 months. In 46 of the 57 eyes, a resolution of the ME was achieved. The pretreatment CRT and MV, presence of intact ELM, EZ, and FB, and PROS length at the time of ME resolution were significantly correlated with the best-corrected visual acuity and retinal sensitivity at the final visit (P<0.050). Multiple regression analyses showed that the pretreatment MV had the highest correlation with the posttreatment best-corrected visual acuity and retinal sensitivity (P<0.050). Conclusion: The CRT, MV, ELM, EZ, FB, and PROS length are predictive factors for the visual outcome after anti-VEGF therapy for RVO. Keywords: anti-VEGF therapy, retinal sensitivity, retinal vein occlusion, spectral-domain optical coherence tomography, visual acuity
format	article
author	Fujihara-Mino A Mitamura Y Inomoto N Sano H Akaiwa K Semba K
author_facet	Fujihara-Mino A Mitamura Y Inomoto N Sano H Akaiwa K Semba K
author_sort	Fujihara-Mino A
title	Optical coherence tomography parameters predictive of visual outcome after anti-VEGF therapy for retinal vein occlusion
title_short	Optical coherence tomography parameters predictive of visual outcome after anti-VEGF therapy for retinal vein occlusion
title_full	Optical coherence tomography parameters predictive of visual outcome after anti-VEGF therapy for retinal vein occlusion
title_fullStr	Optical coherence tomography parameters predictive of visual outcome after anti-VEGF therapy for retinal vein occlusion
title_full_unstemmed	Optical coherence tomography parameters predictive of visual outcome after anti-VEGF therapy for retinal vein occlusion
title_sort	optical coherence tomography parameters predictive of visual outcome after anti-vegf therapy for retinal vein occlusion
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/f0a2d23f434c436bb0ae91ca162d610b
work_keys_str_mv	AT fujiharaminoa opticalcoherencetomographyparameterspredictiveofvisualoutcomeafterantivegftherapyforretinalveinocclusion AT mitamuray opticalcoherencetomographyparameterspredictiveofvisualoutcomeafterantivegftherapyforretinalveinocclusion AT inomoton opticalcoherencetomographyparameterspredictiveofvisualoutcomeafterantivegftherapyforretinalveinocclusion AT sanoh opticalcoherencetomographyparameterspredictiveofvisualoutcomeafterantivegftherapyforretinalveinocclusion AT akaiwak opticalcoherencetomographyparameterspredictiveofvisualoutcomeafterantivegftherapyforretinalveinocclusion AT sembak opticalcoherencetomographyparameterspredictiveofvisualoutcomeafterantivegftherapyforretinalveinocclusion
_version_	1718402747341996032

Optical coherence tomography parameters predictive of visual outcome after anti-VEGF therapy for retinal vein occlusion

Ejemplares similares