Decreased serum C1Q/TNF-related protein 4 concentrations are associated with type 2 diabetes mellitus

Objective: To detect serum C1Q/TNF-related protein 4 (CTRP4) concentrations in patients with newly diagnosed type 2 diabetes mellitus (T2DM) and evaluate the correlation between CTRP4 and other variables in T2DM. Method: Sixty-five patients with newly diagnosed T2DM and eighty-nine healthy volunteer...

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Autores principales:	Zheng Liu, Jinhua Lu, Daiyi Zhang, Lijuan Niu, Bimin Shi
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/f0a432b53d664ad3b1f6265304777661
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spelling	oai:doaj.org-article:f0a432b53d664ad3b1f62653047776612021-12-01T00:05:32ZDecreased serum C1Q/TNF-related protein 4 concentrations are associated with type 2 diabetes mellitus2042-019610.1177/20420188211059884https://doaj.org/article/f0a432b53d664ad3b1f62653047776612021-11-01T00:00:00Zhttps://doi.org/10.1177/20420188211059884https://doaj.org/toc/2042-0196Objective: To detect serum C1Q/TNF-related protein 4 (CTRP4) concentrations in patients with newly diagnosed type 2 diabetes mellitus (T2DM) and evaluate the correlation between CTRP4 and other variables in T2DM. Method: Sixty-five patients with newly diagnosed T2DM and eighty-nine healthy volunteers were enrolled in this study. Anthropometric and biochemical data of the study participants was collected, and serum CTRP4 concentrations were detected by enzyme-linked immunosorbent assay (ELISA) kit. The correlation between serum CTRP4 and other indexes was analyzed by Spearman correlation analysis. Trend χ 2 test and binary multivariate stepwise logistic regression were performed to assess the correlation between CTRP4 and the risk of T2DM. Results: Serum CTRP4 concentrations in the T2DM group were significantly lower than those in the control group ( P < .01). Spearman correlation analysis showed that CTRP4 concentrations were negatively correlated with BMI, hs-CRP, HOMA-IR, FBG and TG ( r = - 0.430, - 0.453, - 0.371, - 0.361, - 0.506, P < .05), and positively correlated with HDL-c ( r = 0.303, P < .05). Trend χ 2 test indicated that with the increase of CTRP4 levels in the population, the risk of T2DM presented a general downward trend ( P < .01). Binary multivariate stepwise logistic regression suggested that serum CTRP4 was an independent impact factor for T2DM and high serum CTRP4 levels were related to the decreased risk of T2DM (P < .05). Conclusions: Serum CTRP4 concentrations decrease in patients with newly diagnosed T2DM. Serum CTRP4 levels are negatively associated with the risk of T2DM.Zheng LiuJinhua LuDaiyi ZhangLijuan NiuBimin ShiSAGE PublishingarticleDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENTherapeutic Advances in Endocrinology and Metabolism, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Diseases of the endocrine glands. Clinical endocrinology RC648-665 Zheng Liu Jinhua Lu Daiyi Zhang Lijuan Niu Bimin Shi Decreased serum C1Q/TNF-related protein 4 concentrations are associated with type 2 diabetes mellitus
description	Objective: To detect serum C1Q/TNF-related protein 4 (CTRP4) concentrations in patients with newly diagnosed type 2 diabetes mellitus (T2DM) and evaluate the correlation between CTRP4 and other variables in T2DM. Method: Sixty-five patients with newly diagnosed T2DM and eighty-nine healthy volunteers were enrolled in this study. Anthropometric and biochemical data of the study participants was collected, and serum CTRP4 concentrations were detected by enzyme-linked immunosorbent assay (ELISA) kit. The correlation between serum CTRP4 and other indexes was analyzed by Spearman correlation analysis. Trend χ 2 test and binary multivariate stepwise logistic regression were performed to assess the correlation between CTRP4 and the risk of T2DM. Results: Serum CTRP4 concentrations in the T2DM group were significantly lower than those in the control group ( P < .01). Spearman correlation analysis showed that CTRP4 concentrations were negatively correlated with BMI, hs-CRP, HOMA-IR, FBG and TG ( r = - 0.430, - 0.453, - 0.371, - 0.361, - 0.506, P < .05), and positively correlated with HDL-c ( r = 0.303, P < .05). Trend χ 2 test indicated that with the increase of CTRP4 levels in the population, the risk of T2DM presented a general downward trend ( P < .01). Binary multivariate stepwise logistic regression suggested that serum CTRP4 was an independent impact factor for T2DM and high serum CTRP4 levels were related to the decreased risk of T2DM (P < .05). Conclusions: Serum CTRP4 concentrations decrease in patients with newly diagnosed T2DM. Serum CTRP4 levels are negatively associated with the risk of T2DM.
format	article
author	Zheng Liu Jinhua Lu Daiyi Zhang Lijuan Niu Bimin Shi
author_facet	Zheng Liu Jinhua Lu Daiyi Zhang Lijuan Niu Bimin Shi
author_sort	Zheng Liu
title	Decreased serum C1Q/TNF-related protein 4 concentrations are associated with type 2 diabetes mellitus
title_short	Decreased serum C1Q/TNF-related protein 4 concentrations are associated with type 2 diabetes mellitus
title_full	Decreased serum C1Q/TNF-related protein 4 concentrations are associated with type 2 diabetes mellitus
title_fullStr	Decreased serum C1Q/TNF-related protein 4 concentrations are associated with type 2 diabetes mellitus
title_full_unstemmed	Decreased serum C1Q/TNF-related protein 4 concentrations are associated with type 2 diabetes mellitus
title_sort	decreased serum c1q/tnf-related protein 4 concentrations are associated with type 2 diabetes mellitus
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/f0a432b53d664ad3b1f6265304777661
work_keys_str_mv	AT zhengliu decreasedserumc1qtnfrelatedprotein4concentrationsareassociatedwithtype2diabetesmellitus AT jinhualu decreasedserumc1qtnfrelatedprotein4concentrationsareassociatedwithtype2diabetesmellitus AT daiyizhang decreasedserumc1qtnfrelatedprotein4concentrationsareassociatedwithtype2diabetesmellitus AT lijuanniu decreasedserumc1qtnfrelatedprotein4concentrationsareassociatedwithtype2diabetesmellitus AT biminshi decreasedserumc1qtnfrelatedprotein4concentrationsareassociatedwithtype2diabetesmellitus
_version_	1718406176043958272

Decreased serum C1Q/TNF-related protein 4 concentrations are associated with type 2 diabetes mellitus

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