Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet

Abstract Epidemiological studies have indicated that rural living might be protective against type 2 diabetes development. We compared the metabolic profile and response to a short-term high-fat high-calorie diet (HFD) of men with the same genetic background living in an urban and rural area of Indo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dicky L. Tahapary, Karin de Ruiter, Farid Kurniawan, Yenny Djuardi, Yanan Wang, Siti M. E. Nurdin, Elisa Iskandar, Dominggus Minggu, Em Yunir, Bruno Guigas, Taniawati Supali, Patrick C. N. Rensen, Erliyani Sartono, Pradana Soewondo, Dante S. Harbuwono, Johannes W. A. Smit, Maria Yazdanbakhsh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f0aadfa327ef4384bf168fe6d66930fd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f0aadfa327ef4384bf168fe6d66930fd
record_format	dspace
spelling	oai:doaj.org-article:f0aadfa327ef4384bf168fe6d66930fd2021-12-02T15:07:49ZImpact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet10.1038/s41598-018-25092-62045-2322https://doaj.org/article/f0aadfa327ef4384bf168fe6d66930fd2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25092-6https://doaj.org/toc/2045-2322Abstract Epidemiological studies have indicated that rural living might be protective against type 2 diabetes development. We compared the metabolic profile and response to a short-term high-fat high-calorie diet (HFD) of men with the same genetic background living in an urban and rural area of Indonesia. First, we recruited 154 Floresian male subjects (18–65 years old), of whom 105 lived in a rural area (Flores) and 49 had migrated and lived in urban area (Jakarta) for more than 1 year. The urban group had significantly higher whole-body insulin resistance (IR), as assessed by homeostatic-model-assessment of IR (HOMA-IR), [mean difference (95% CI), p-value: 0.10 (0.02–0.17), p = 0.01]. Next, we recruited 17 urban and 17 rural age-and-BMI-matched healthy-young-male volunteers for a 5-day HFD challenge. The HOMA-IR increased in both groups similarly −0.77 (−2.03–0.49), p = 0.22]. Neither rural living nor factors associated with rural living, such as current helminth infection or total IgE, were associated with protection against acute induction of IR by HFD.Dicky L. TahaparyKarin de RuiterFarid KurniawanYenny DjuardiYanan WangSiti M. E. NurdinElisa IskandarDominggus MingguEm YunirBruno GuigasTaniawati SupaliPatrick C. N. RensenErliyani SartonoPradana SoewondoDante S. HarbuwonoJohannes W. A. SmitMaria YazdanbakhshNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dicky L. Tahapary Karin de Ruiter Farid Kurniawan Yenny Djuardi Yanan Wang Siti M. E. Nurdin Elisa Iskandar Dominggus Minggu Em Yunir Bruno Guigas Taniawati Supali Patrick C. N. Rensen Erliyani Sartono Pradana Soewondo Dante S. Harbuwono Johannes W. A. Smit Maria Yazdanbakhsh Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet
description	Abstract Epidemiological studies have indicated that rural living might be protective against type 2 diabetes development. We compared the metabolic profile and response to a short-term high-fat high-calorie diet (HFD) of men with the same genetic background living in an urban and rural area of Indonesia. First, we recruited 154 Floresian male subjects (18–65 years old), of whom 105 lived in a rural area (Flores) and 49 had migrated and lived in urban area (Jakarta) for more than 1 year. The urban group had significantly higher whole-body insulin resistance (IR), as assessed by homeostatic-model-assessment of IR (HOMA-IR), [mean difference (95% CI), p-value: 0.10 (0.02–0.17), p = 0.01]. Next, we recruited 17 urban and 17 rural age-and-BMI-matched healthy-young-male volunteers for a 5-day HFD challenge. The HOMA-IR increased in both groups similarly −0.77 (−2.03–0.49), p = 0.22]. Neither rural living nor factors associated with rural living, such as current helminth infection or total IgE, were associated with protection against acute induction of IR by HFD.
format	article
author	Dicky L. Tahapary Karin de Ruiter Farid Kurniawan Yenny Djuardi Yanan Wang Siti M. E. Nurdin Elisa Iskandar Dominggus Minggu Em Yunir Bruno Guigas Taniawati Supali Patrick C. N. Rensen Erliyani Sartono Pradana Soewondo Dante S. Harbuwono Johannes W. A. Smit Maria Yazdanbakhsh
author_facet	Dicky L. Tahapary Karin de Ruiter Farid Kurniawan Yenny Djuardi Yanan Wang Siti M. E. Nurdin Elisa Iskandar Dominggus Minggu Em Yunir Bruno Guigas Taniawati Supali Patrick C. N. Rensen Erliyani Sartono Pradana Soewondo Dante S. Harbuwono Johannes W. A. Smit Maria Yazdanbakhsh
author_sort	Dicky L. Tahapary
title	Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet
title_short	Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet
title_full	Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet
title_fullStr	Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet
title_full_unstemmed	Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet
title_sort	impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f0aadfa327ef4384bf168fe6d66930fd
work_keys_str_mv	AT dickyltahapary impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT karinderuiter impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT faridkurniawan impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT yennydjuardi impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT yananwang impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT sitimenurdin impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT elisaiskandar impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT dominggusminggu impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT emyunir impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT brunoguigas impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT taniawatisupali impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT patrickcnrensen impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT erliyanisartono impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT pradanasoewondo impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT dantesharbuwono impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT johanneswasmit impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet AT mariayazdanbakhsh impactofruralurbanenvironmentonmetabolicprofileandresponsetoa5dayhighfatdiet
_version_	1718388423759233024

Impact of rural-urban environment on metabolic profile and response to a 5-day high-fat diet

Ejemplares similares