Long-acting protein drugs for the treatment of ocular diseases
Retinal vascular disease treatments involve frequent pharmacological intraocular administrations. Here the authors present a method to increase the half-life of injected drugs by fusing these to a hyaluronan-binding peptide, which might lead to less frequent retinal disease treatments.
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Nature Portfolio
2017
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oai:doaj.org-article:f0adf43d440f4267b734d5d4506d71862021-12-02T14:42:05ZLong-acting protein drugs for the treatment of ocular diseases10.1038/ncomms148372041-1723https://doaj.org/article/f0adf43d440f4267b734d5d4506d71862017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14837https://doaj.org/toc/2041-1723Retinal vascular disease treatments involve frequent pharmacological intraocular administrations. Here the authors present a method to increase the half-life of injected drugs by fusing these to a hyaluronan-binding peptide, which might lead to less frequent retinal disease treatments.Joy G. GhoshAndrew A. NguyenChad E. BigelowStephen PoorYubin QiuNalini RangaswamyRichard OrnbergBrittany JacksonHoward MakTucker EzellVania KenanovaElisa de la CruzAna CarrionBijan Etemad-GilbertsonRoxana Garcia CaroKan ZhuVinney GeorgeJirong BaiRadhika Sharma-NaharSiyuan ShenYiqin WangKulandayan K. SubramanianElizabeth FassbenderMichael MakerShawn HanksJoanna VrouvlianisBarrett LeehyDebby LongMelissa PrentissViral KansaraBruce JaffeeThaddeus P. DryjaMichael RoguskaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Joy G. Ghosh Andrew A. Nguyen Chad E. Bigelow Stephen Poor Yubin Qiu Nalini Rangaswamy Richard Ornberg Brittany Jackson Howard Mak Tucker Ezell Vania Kenanova Elisa de la Cruz Ana Carrion Bijan Etemad-Gilbertson Roxana Garcia Caro Kan Zhu Vinney George Jirong Bai Radhika Sharma-Nahar Siyuan Shen Yiqin Wang Kulandayan K. Subramanian Elizabeth Fassbender Michael Maker Shawn Hanks Joanna Vrouvlianis Barrett Leehy Debby Long Melissa Prentiss Viral Kansara Bruce Jaffee Thaddeus P. Dryja Michael Roguska Long-acting protein drugs for the treatment of ocular diseases |
| description |
Retinal vascular disease treatments involve frequent pharmacological intraocular administrations. Here the authors present a method to increase the half-life of injected drugs by fusing these to a hyaluronan-binding peptide, which might lead to less frequent retinal disease treatments. |
| format |
article |
| author |
Joy G. Ghosh Andrew A. Nguyen Chad E. Bigelow Stephen Poor Yubin Qiu Nalini Rangaswamy Richard Ornberg Brittany Jackson Howard Mak Tucker Ezell Vania Kenanova Elisa de la Cruz Ana Carrion Bijan Etemad-Gilbertson Roxana Garcia Caro Kan Zhu Vinney George Jirong Bai Radhika Sharma-Nahar Siyuan Shen Yiqin Wang Kulandayan K. Subramanian Elizabeth Fassbender Michael Maker Shawn Hanks Joanna Vrouvlianis Barrett Leehy Debby Long Melissa Prentiss Viral Kansara Bruce Jaffee Thaddeus P. Dryja Michael Roguska |
| author_facet |
Joy G. Ghosh Andrew A. Nguyen Chad E. Bigelow Stephen Poor Yubin Qiu Nalini Rangaswamy Richard Ornberg Brittany Jackson Howard Mak Tucker Ezell Vania Kenanova Elisa de la Cruz Ana Carrion Bijan Etemad-Gilbertson Roxana Garcia Caro Kan Zhu Vinney George Jirong Bai Radhika Sharma-Nahar Siyuan Shen Yiqin Wang Kulandayan K. Subramanian Elizabeth Fassbender Michael Maker Shawn Hanks Joanna Vrouvlianis Barrett Leehy Debby Long Melissa Prentiss Viral Kansara Bruce Jaffee Thaddeus P. Dryja Michael Roguska |
| author_sort |
Joy G. Ghosh |
| title |
Long-acting protein drugs for the treatment of ocular diseases |
| title_short |
Long-acting protein drugs for the treatment of ocular diseases |
| title_full |
Long-acting protein drugs for the treatment of ocular diseases |
| title_fullStr |
Long-acting protein drugs for the treatment of ocular diseases |
| title_full_unstemmed |
Long-acting protein drugs for the treatment of ocular diseases |
| title_sort |
long-acting protein drugs for the treatment of ocular diseases |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/f0adf43d440f4267b734d5d4506d7186 |
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