Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

Abstract Silicosis is a diffuse interstitial lung disease caused by sustained inhalation of silica and silicates. Several cytokines are activated by their inhalation and can mediate the process of pulmonary fibrosis. The identification of biomarkers could allow an early diagnosis before the developm...

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Autores principales:	José Jesús Blanco-Pérez, Sara Blanco-Dorado, Javier Rodríguez-García, Mª Elena Gonzalez-Bello, Ángel Salgado-Barreira, Adriana Carolina Caldera-Díaz, Abel Pallarés-Sanmartín, Alberto Fernandez-Villar, Francisco Javier González-Barcala
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f0ae9aaa03634037a7ccabc00620feff
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spelling	oai:doaj.org-article:f0ae9aaa03634037a7ccabc00620feff2021-12-02T18:02:54ZSerum levels of inflammatory mediators as prognostic biomarker in silica exposed workers10.1038/s41598-021-92587-02045-2322https://doaj.org/article/f0ae9aaa03634037a7ccabc00620feff2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92587-0https://doaj.org/toc/2045-2322Abstract Silicosis is a diffuse interstitial lung disease caused by sustained inhalation of silica and silicates. Several cytokines are activated by their inhalation and can mediate the process of pulmonary fibrosis. The identification of biomarkers could allow an early diagnosis before the development of radiological alterations and help monitor the evolution of patients. The objetive of this study was to determine the clinical significance of specific biomarkers, to estimate their association with the development, severity and/or progression of silicosis, and identify determinants of this evolution. We conducted a prospective observational study in patients attending the pulmonology clinic from 2009 to 2018. Serum levels of the following inflammatory mediators were assessed: interleukin-6 (IL-6), interleukin 2 receptor subunit alpha (IL2R) interleukin 1 beta (IL1B), interleukin-8 (IL-8), tumour necrosis factor-alpha (TNF-α), transforming growth factor-beta1 (TGF-β1), alpha-1 antitrypsin (AAT), C-reactive protein (CRP), lactate dehydrogenase (LDH) and ferritin in subjects exposed to silica, with and without silicosis. Association between those inflammatory mediators with lung function measurements and radiological severity of disease and their impact on prognosis were analysed. 337 exposed to silica (278 with silicosis) and 30 subjects in the control group were included. IL-8, α1AT, ferritin, CRP and LDH levels were higher in silicosis than in those exposed to silica without silicosis. IL-8, LDH and AAT levels were associated with progression of silicosis and IL-6, IL-8, LDH, AAT, ferritin, and CRP with vital status. The results of the ROC analysis indicated the potential of IL-8 as a biomarker in the presence of silicosis and for the prediction of mortality.José Jesús Blanco-PérezSara Blanco-DoradoJavier Rodríguez-GarcíaMª Elena Gonzalez-BelloÁngel Salgado-BarreiraAdriana Carolina Caldera-DíazAbel Pallarés-SanmartínAlberto Fernandez-VillarFrancisco Javier González-BarcalaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q José Jesús Blanco-Pérez Sara Blanco-Dorado Javier Rodríguez-García Mª Elena Gonzalez-Bello Ángel Salgado-Barreira Adriana Carolina Caldera-Díaz Abel Pallarés-Sanmartín Alberto Fernandez-Villar Francisco Javier González-Barcala Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers
description	Abstract Silicosis is a diffuse interstitial lung disease caused by sustained inhalation of silica and silicates. Several cytokines are activated by their inhalation and can mediate the process of pulmonary fibrosis. The identification of biomarkers could allow an early diagnosis before the development of radiological alterations and help monitor the evolution of patients. The objetive of this study was to determine the clinical significance of specific biomarkers, to estimate their association with the development, severity and/or progression of silicosis, and identify determinants of this evolution. We conducted a prospective observational study in patients attending the pulmonology clinic from 2009 to 2018. Serum levels of the following inflammatory mediators were assessed: interleukin-6 (IL-6), interleukin 2 receptor subunit alpha (IL2R) interleukin 1 beta (IL1B), interleukin-8 (IL-8), tumour necrosis factor-alpha (TNF-α), transforming growth factor-beta1 (TGF-β1), alpha-1 antitrypsin (AAT), C-reactive protein (CRP), lactate dehydrogenase (LDH) and ferritin in subjects exposed to silica, with and without silicosis. Association between those inflammatory mediators with lung function measurements and radiological severity of disease and their impact on prognosis were analysed. 337 exposed to silica (278 with silicosis) and 30 subjects in the control group were included. IL-8, α1AT, ferritin, CRP and LDH levels were higher in silicosis than in those exposed to silica without silicosis. IL-8, LDH and AAT levels were associated with progression of silicosis and IL-6, IL-8, LDH, AAT, ferritin, and CRP with vital status. The results of the ROC analysis indicated the potential of IL-8 as a biomarker in the presence of silicosis and for the prediction of mortality.
format	article
author	José Jesús Blanco-Pérez Sara Blanco-Dorado Javier Rodríguez-García Mª Elena Gonzalez-Bello Ángel Salgado-Barreira Adriana Carolina Caldera-Díaz Abel Pallarés-Sanmartín Alberto Fernandez-Villar Francisco Javier González-Barcala
author_facet	José Jesús Blanco-Pérez Sara Blanco-Dorado Javier Rodríguez-García Mª Elena Gonzalez-Bello Ángel Salgado-Barreira Adriana Carolina Caldera-Díaz Abel Pallarés-Sanmartín Alberto Fernandez-Villar Francisco Javier González-Barcala
author_sort	José Jesús Blanco-Pérez
title	Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers
title_short	Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers
title_full	Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers
title_fullStr	Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers
title_full_unstemmed	Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers
title_sort	serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f0ae9aaa03634037a7ccabc00620feff
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_version_	1718378843623915520

Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

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