Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences

Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction associated with (i) chimeric antigen receptor (CAR)-T cell therapy, (ii) therapeutic antibodies, and (iii) haploidentical allogeneic stem cell transplantation (haplo-allo-...

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Autores principales:	Tor Henrik Anderson Tvedt, Anh Khoi Vo, Øystein Bruserud, Håkon Reikvam
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cytokines chimeric antigen receptor therapeutic antibodies haploidentical allogeneic stem cell transplantation Medicine R
Acceso en línea:	https://doaj.org/article/f0af6da2777f473186d1684ee863dffe
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spelling	oai:doaj.org-article:f0af6da2777f473186d1684ee863dffe2021-11-11T17:47:47ZCytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences10.3390/jcm102151902077-0383https://doaj.org/article/f0af6da2777f473186d1684ee863dffe2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5190https://doaj.org/toc/2077-0383Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction associated with (i) chimeric antigen receptor (CAR)-T cell therapy, (ii) therapeutic antibodies, and (iii) haploidentical allogeneic stem cell transplantation (haplo-allo-HSCT). Severe CRS can be life-threatening in some cases and requires prompt management of those toxicities and is still a great challenge for physicians. The pathophysiology of CRS is still not fully understood, which also applies to the identifications of predictive biomarkers that can forecast these features in advance. However, a broad range of cytokines are involved in the dynamics of CRS. Treatment approaches include both broad spectrum of immunosuppressant, such as corticosteroids, as well as more specific inhibition of cytokine release. In the present manuscript we will try to review an update regarding pathophysiology, etiology, diagnostics, and therapeutic options for this serious complication.Tor Henrik Anderson TvedtAnh Khoi VoØystein BruserudHåkon ReikvamMDPI AGarticlecytokineschimeric antigen receptortherapeutic antibodieshaploidentical allogeneic stem cell transplantationMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5190, p 5190 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytokines chimeric antigen receptor therapeutic antibodies haploidentical allogeneic stem cell transplantation Medicine R
spellingShingle	cytokines chimeric antigen receptor therapeutic antibodies haploidentical allogeneic stem cell transplantation Medicine R Tor Henrik Anderson Tvedt Anh Khoi Vo Øystein Bruserud Håkon Reikvam Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences
description	Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction associated with (i) chimeric antigen receptor (CAR)-T cell therapy, (ii) therapeutic antibodies, and (iii) haploidentical allogeneic stem cell transplantation (haplo-allo-HSCT). Severe CRS can be life-threatening in some cases and requires prompt management of those toxicities and is still a great challenge for physicians. The pathophysiology of CRS is still not fully understood, which also applies to the identifications of predictive biomarkers that can forecast these features in advance. However, a broad range of cytokines are involved in the dynamics of CRS. Treatment approaches include both broad spectrum of immunosuppressant, such as corticosteroids, as well as more specific inhibition of cytokine release. In the present manuscript we will try to review an update regarding pathophysiology, etiology, diagnostics, and therapeutic options for this serious complication.
format	article
author	Tor Henrik Anderson Tvedt Anh Khoi Vo Øystein Bruserud Håkon Reikvam
author_facet	Tor Henrik Anderson Tvedt Anh Khoi Vo Øystein Bruserud Håkon Reikvam
author_sort	Tor Henrik Anderson Tvedt
title	Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences
title_short	Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences
title_full	Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences
title_fullStr	Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences
title_full_unstemmed	Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences
title_sort	cytokine release syndrome in the immunotherapy of hematological malignancies: the biology behind and possible clinical consequences
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f0af6da2777f473186d1684ee863dffe
work_keys_str_mv	AT torhenrikandersontvedt cytokinereleasesyndromeintheimmunotherapyofhematologicalmalignanciesthebiologybehindandpossibleclinicalconsequences AT anhkhoivo cytokinereleasesyndromeintheimmunotherapyofhematologicalmalignanciesthebiologybehindandpossibleclinicalconsequences AT øysteinbruserud cytokinereleasesyndromeintheimmunotherapyofhematologicalmalignanciesthebiologybehindandpossibleclinicalconsequences AT hakonreikvam cytokinereleasesyndromeintheimmunotherapyofhematologicalmalignanciesthebiologybehindandpossibleclinicalconsequences
_version_	1718432035615277056

Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences

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