Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC

Treatment of EGFR mutant non-small cell lung cancer (NSCLC) often develops resistance to EGFR TKIs. In this study, the authors discover a non-canonical activation of β-catenin signaling through Notch3 as a mechanism of adaptation to and resistance to EGFR TKI treatment in NSCLC.

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Autores principales:	Rajeswara Rao Arasada, Konstantin Shilo, Tadaaki Yamada, Jianying Zhang, Seiji Yano, Rashelle Ghanem, Walter Wang, Shinji Takeuchi, Koji Fukuda, Nobuyuki Katakami, Keisuke Tomii, Fumitaka Ogushi, Yasuhiko Nishioka, Tiffany Talabere, Shrilekha Misra, Wenrui Duan, Paolo Fadda, Mohammad A. Rahman, Patrick Nana-Sinkam, Jason Evans, Joseph Amann, Elena E. Tchekneva, Mikhail M. Dikov, David P. Carbone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f0b02e3948464f6081e96b751e406253
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spelling	oai:doaj.org-article:f0b02e3948464f6081e96b751e4062532021-12-02T15:34:38ZNotch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC10.1038/s41467-018-05626-22041-1723https://doaj.org/article/f0b02e3948464f6081e96b751e4062532018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05626-2https://doaj.org/toc/2041-1723Treatment of EGFR mutant non-small cell lung cancer (NSCLC) often develops resistance to EGFR TKIs. In this study, the authors discover a non-canonical activation of β-catenin signaling through Notch3 as a mechanism of adaptation to and resistance to EGFR TKI treatment in NSCLC.Rajeswara Rao ArasadaKonstantin ShiloTadaaki YamadaJianying ZhangSeiji YanoRashelle GhanemWalter WangShinji TakeuchiKoji FukudaNobuyuki KatakamiKeisuke TomiiFumitaka OgushiYasuhiko NishiokaTiffany TalabereShrilekha MisraWenrui DuanPaolo FaddaMohammad A. RahmanPatrick Nana-SinkamJason EvansJoseph AmannElena E. TcheknevaMikhail M. DikovDavid P. CarboneNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rajeswara Rao Arasada Konstantin Shilo Tadaaki Yamada Jianying Zhang Seiji Yano Rashelle Ghanem Walter Wang Shinji Takeuchi Koji Fukuda Nobuyuki Katakami Keisuke Tomii Fumitaka Ogushi Yasuhiko Nishioka Tiffany Talabere Shrilekha Misra Wenrui Duan Paolo Fadda Mohammad A. Rahman Patrick Nana-Sinkam Jason Evans Joseph Amann Elena E. Tchekneva Mikhail M. Dikov David P. Carbone Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC
description	Treatment of EGFR mutant non-small cell lung cancer (NSCLC) often develops resistance to EGFR TKIs. In this study, the authors discover a non-canonical activation of β-catenin signaling through Notch3 as a mechanism of adaptation to and resistance to EGFR TKI treatment in NSCLC.
format	article
author	Rajeswara Rao Arasada Konstantin Shilo Tadaaki Yamada Jianying Zhang Seiji Yano Rashelle Ghanem Walter Wang Shinji Takeuchi Koji Fukuda Nobuyuki Katakami Keisuke Tomii Fumitaka Ogushi Yasuhiko Nishioka Tiffany Talabere Shrilekha Misra Wenrui Duan Paolo Fadda Mohammad A. Rahman Patrick Nana-Sinkam Jason Evans Joseph Amann Elena E. Tchekneva Mikhail M. Dikov David P. Carbone
author_facet	Rajeswara Rao Arasada Konstantin Shilo Tadaaki Yamada Jianying Zhang Seiji Yano Rashelle Ghanem Walter Wang Shinji Takeuchi Koji Fukuda Nobuyuki Katakami Keisuke Tomii Fumitaka Ogushi Yasuhiko Nishioka Tiffany Talabere Shrilekha Misra Wenrui Duan Paolo Fadda Mohammad A. Rahman Patrick Nana-Sinkam Jason Evans Joseph Amann Elena E. Tchekneva Mikhail M. Dikov David P. Carbone
author_sort	Rajeswara Rao Arasada
title	Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC
title_short	Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC
title_full	Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC
title_fullStr	Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC
title_full_unstemmed	Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC
title_sort	notch3-dependent β-catenin signaling mediates egfr tki drug persistence in egfr mutant nsclc
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f0b02e3948464f6081e96b751e406253
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Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC

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