Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions

Adenovirus based (AdV) vectors are promising platforms for therapeutics and vaccines, but receptor usage of serotypes in clinical development remains unclear. Here, based on crystal structures and modeling, Baker et al. show that HAdV-D26/48 fiber knob protein interacts weakly with CAR but not with...

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Autores principales:	Alexander T. Baker, Alexander Greenshields-Watson, Lynda Coughlan, James A. Davies, Hanni Uusi-Kerttula, David K. Cole, Pierre J. Rizkallah, Alan L. Parker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f0b1e1b1b41e4d7397fac97ab6273893
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spelling	oai:doaj.org-article:f0b1e1b1b41e4d7397fac97ab62738932021-12-02T16:57:36ZDiversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions10.1038/s41467-019-08599-y2041-1723https://doaj.org/article/f0b1e1b1b41e4d7397fac97ab62738932019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08599-yhttps://doaj.org/toc/2041-1723Adenovirus based (AdV) vectors are promising platforms for therapeutics and vaccines, but receptor usage of serotypes in clinical development remains unclear. Here, based on crystal structures and modeling, Baker et al. show that HAdV-D26/48 fiber knob protein interacts weakly with CAR but not with CD46 or DSG2.Alexander T. BakerAlexander Greenshields-WatsonLynda CoughlanJames A. DaviesHanni Uusi-KerttulaDavid K. ColePierre J. RizkallahAlan L. ParkerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander T. Baker Alexander Greenshields-Watson Lynda Coughlan James A. Davies Hanni Uusi-Kerttula David K. Cole Pierre J. Rizkallah Alan L. Parker Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions
description	Adenovirus based (AdV) vectors are promising platforms for therapeutics and vaccines, but receptor usage of serotypes in clinical development remains unclear. Here, based on crystal structures and modeling, Baker et al. show that HAdV-D26/48 fiber knob protein interacts weakly with CAR but not with CD46 or DSG2.
format	article
author	Alexander T. Baker Alexander Greenshields-Watson Lynda Coughlan James A. Davies Hanni Uusi-Kerttula David K. Cole Pierre J. Rizkallah Alan L. Parker
author_facet	Alexander T. Baker Alexander Greenshields-Watson Lynda Coughlan James A. Davies Hanni Uusi-Kerttula David K. Cole Pierre J. Rizkallah Alan L. Parker
author_sort	Alexander T. Baker
title	Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions
title_short	Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions
title_full	Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions
title_fullStr	Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions
title_full_unstemmed	Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions
title_sort	diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f0b1e1b1b41e4d7397fac97ab6273893
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Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions

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