Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas

Circular RNAs (circRNAs) are single-stranded RNAs generated from exons back-splicing from a single pre-mRNA, forming covalently closed loop structures which lack 5′-3′-polarity or polyadenylated tail. Ongoing research depicts that circRNAs play a pivotal role in tumorigenesis, tumor progression, met...

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Autores principales:	Eleftheria Lakiotaki, Dimitrios S. Kanakoglou, Andromachi Pampalou, Eleni A. Karatrasoglou, Christina Piperi, Penelope Korkolopoulou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	circular RNAs osteosarcoma Kaposi sarcoma rhabdomyosarcoma gastrointestinal stromal tumors diagnosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f0b56746449b4069acd286b3700d6527
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spelling	oai:doaj.org-article:f0b56746449b4069acd286b3700d65272021-11-25T16:50:03ZDissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas10.3390/biomedicines91116422227-9059https://doaj.org/article/f0b56746449b4069acd286b3700d65272021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1642https://doaj.org/toc/2227-9059Circular RNAs (circRNAs) are single-stranded RNAs generated from exons back-splicing from a single pre-mRNA, forming covalently closed loop structures which lack 5′-3′-polarity or polyadenylated tail. Ongoing research depicts that circRNAs play a pivotal role in tumorigenesis, tumor progression, metastatic potential and chemoresistance by regulating transcription, microRNA (miRNA) sponging, RNA-binding protein interactions, alternative splicing and to a lesser degree, protein coding. Sarcomas are rare malignant tumors stemming from mesenchymal cells. Due to their clinically insidious onset, they often present at advanced stage and their treatment may require aggressive chemotherapeutic or surgical options. This review is mainly focused on the regulatory functions of circRNAs on osteosarcoma progression and their potential role as biomarkers, an area which has prompted lately extensive research. The attributed oncogenic role of circRNAs on other mesenchymal tumors such as Kaposi Sarcoma (KS), Rhabdomyosarcoma (RMS) or Gastrointestinal Stromal Tumors (GISTs) is also described. The involvement of circRNAs on sarcoma oncogenesis and relevant emerging diagnostic, prognostic and therapeutic applications are expected to gain more research interest in the future.Eleftheria LakiotakiDimitrios S. KanakoglouAndromachi PampalouEleni A. KaratrasoglouChristina PiperiPenelope KorkolopoulouMDPI AGarticlecircular RNAsosteosarcomaKaposi sarcomarhabdomyosarcomagastrointestinal stromal tumorsdiagnosisBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1642, p 1642 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circular RNAs osteosarcoma Kaposi sarcoma rhabdomyosarcoma gastrointestinal stromal tumors diagnosis Biology (General) QH301-705.5
spellingShingle	circular RNAs osteosarcoma Kaposi sarcoma rhabdomyosarcoma gastrointestinal stromal tumors diagnosis Biology (General) QH301-705.5 Eleftheria Lakiotaki Dimitrios S. Kanakoglou Andromachi Pampalou Eleni A. Karatrasoglou Christina Piperi Penelope Korkolopoulou Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas
description	Circular RNAs (circRNAs) are single-stranded RNAs generated from exons back-splicing from a single pre-mRNA, forming covalently closed loop structures which lack 5′-3′-polarity or polyadenylated tail. Ongoing research depicts that circRNAs play a pivotal role in tumorigenesis, tumor progression, metastatic potential and chemoresistance by regulating transcription, microRNA (miRNA) sponging, RNA-binding protein interactions, alternative splicing and to a lesser degree, protein coding. Sarcomas are rare malignant tumors stemming from mesenchymal cells. Due to their clinically insidious onset, they often present at advanced stage and their treatment may require aggressive chemotherapeutic or surgical options. This review is mainly focused on the regulatory functions of circRNAs on osteosarcoma progression and their potential role as biomarkers, an area which has prompted lately extensive research. The attributed oncogenic role of circRNAs on other mesenchymal tumors such as Kaposi Sarcoma (KS), Rhabdomyosarcoma (RMS) or Gastrointestinal Stromal Tumors (GISTs) is also described. The involvement of circRNAs on sarcoma oncogenesis and relevant emerging diagnostic, prognostic and therapeutic applications are expected to gain more research interest in the future.
format	article
author	Eleftheria Lakiotaki Dimitrios S. Kanakoglou Andromachi Pampalou Eleni A. Karatrasoglou Christina Piperi Penelope Korkolopoulou
author_facet	Eleftheria Lakiotaki Dimitrios S. Kanakoglou Andromachi Pampalou Eleni A. Karatrasoglou Christina Piperi Penelope Korkolopoulou
author_sort	Eleftheria Lakiotaki
title	Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas
title_short	Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas
title_full	Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas
title_fullStr	Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas
title_full_unstemmed	Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas
title_sort	dissecting the role of circular rnas in sarcomas with emphasis on osteosarcomas
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f0b56746449b4069acd286b3700d6527
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Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas

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