NGAL as a Potential Target in Tumor Microenvironment

The signaling network between cancer and stromal cells plays a crucial role in tumor microenvironment. The fate of tumor progression mainly depends on the huge amount of information that these cell populations exchange from the onset of neoplastic transformation. Interfering with such signaling has...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elvira Crescenzi, Antonio Leonardi, Francesco Pacifico
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	NGAL tumor stroma iron siderophores SASP Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f0b6c2afef364de7a9218ec9cd0b8c23
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f0b6c2afef364de7a9218ec9cd0b8c23
record_format	dspace
spelling	oai:doaj.org-article:f0b6c2afef364de7a9218ec9cd0b8c232021-11-25T17:55:28ZNGAL as a Potential Target in Tumor Microenvironment10.3390/ijms2222123331422-00671661-6596https://doaj.org/article/f0b6c2afef364de7a9218ec9cd0b8c232021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12333https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The signaling network between cancer and stromal cells plays a crucial role in tumor microenvironment. The fate of tumor progression mainly depends on the huge amount of information that these cell populations exchange from the onset of neoplastic transformation. Interfering with such signaling has been producing exciting results in cancer therapy: just think of anti-PD-1/anti-PD-L1/anti-CTLA-4 antibodies that, acting as immune checkpoint inhibitors, interrupt the inhibitory signaling exerted by cancer cells on immune cells or the CAR-T technology that fosters the reactivation of anti-tumoral immunity in a restricted group of leukemias and lymphomas. Nevertheless, many types of cancers, in particular solid tumors, are still refractory to these treatments, so the identification of novel molecular targets in tumor secretome would benefit from implementation of current anti-cancer therapeutical strategies. Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a secreted protein abundantly expressed in the secretome of various human tumors. It represents a promising target for the multiple roles that are played inside cancer and stromal cells, and also overall in their cross-talk. The review focuses on the different roles of NGAL in tumor microenvironment and in cancer senescence-associated secretory phenotype (SASP), highlighting the most crucial functions that could be eventually targetable in cancer therapy.Elvira CrescenziAntonio LeonardiFrancesco PacificoMDPI AGarticleNGALtumor stromaironsiderophoresSASPBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12333, p 12333 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NGAL tumor stroma iron siderophores SASP Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	NGAL tumor stroma iron siderophores SASP Biology (General) QH301-705.5 Chemistry QD1-999 Elvira Crescenzi Antonio Leonardi Francesco Pacifico NGAL as a Potential Target in Tumor Microenvironment
description	The signaling network between cancer and stromal cells plays a crucial role in tumor microenvironment. The fate of tumor progression mainly depends on the huge amount of information that these cell populations exchange from the onset of neoplastic transformation. Interfering with such signaling has been producing exciting results in cancer therapy: just think of anti-PD-1/anti-PD-L1/anti-CTLA-4 antibodies that, acting as immune checkpoint inhibitors, interrupt the inhibitory signaling exerted by cancer cells on immune cells or the CAR-T technology that fosters the reactivation of anti-tumoral immunity in a restricted group of leukemias and lymphomas. Nevertheless, many types of cancers, in particular solid tumors, are still refractory to these treatments, so the identification of novel molecular targets in tumor secretome would benefit from implementation of current anti-cancer therapeutical strategies. Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a secreted protein abundantly expressed in the secretome of various human tumors. It represents a promising target for the multiple roles that are played inside cancer and stromal cells, and also overall in their cross-talk. The review focuses on the different roles of NGAL in tumor microenvironment and in cancer senescence-associated secretory phenotype (SASP), highlighting the most crucial functions that could be eventually targetable in cancer therapy.
format	article
author	Elvira Crescenzi Antonio Leonardi Francesco Pacifico
author_facet	Elvira Crescenzi Antonio Leonardi Francesco Pacifico
author_sort	Elvira Crescenzi
title	NGAL as a Potential Target in Tumor Microenvironment
title_short	NGAL as a Potential Target in Tumor Microenvironment
title_full	NGAL as a Potential Target in Tumor Microenvironment
title_fullStr	NGAL as a Potential Target in Tumor Microenvironment
title_full_unstemmed	NGAL as a Potential Target in Tumor Microenvironment
title_sort	ngal as a potential target in tumor microenvironment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f0b6c2afef364de7a9218ec9cd0b8c23
work_keys_str_mv	AT elviracrescenzi ngalasapotentialtargetintumormicroenvironment AT antonioleonardi ngalasapotentialtargetintumormicroenvironment AT francescopacifico ngalasapotentialtargetintumormicroenvironment
_version_	1718411838848237568

NGAL as a Potential Target in Tumor Microenvironment

Ejemplares similares