A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia

The molecular pathway(s) driving antipsychotics (AP) induced hyperphagia remains unclear. A novel C. elegans system is used here to screen for FDA approved drugs that selectively suppresses this response, unraveling potential molecular mediators influencing AP induced hyperphagia in mouse models.

Guardado en:

Detalles Bibliográficos
Autores principales:	Anabel Perez-Gomez, Maria Carretero, Natalie Weber, Veronika Peterka, Alan To, Viktoriya Titova, Gregory Solis, Olivia Osborn, Michael Petrascheck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f0bb27eb5a4746e6b17de6526ad7e3a7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f0bb27eb5a4746e6b17de6526ad7e3a7
record_format	dspace
spelling	oai:doaj.org-article:f0bb27eb5a4746e6b17de6526ad7e3a72021-12-02T17:31:59ZA phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia10.1038/s41467-018-07684-y2041-1723https://doaj.org/article/f0bb27eb5a4746e6b17de6526ad7e3a72018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07684-yhttps://doaj.org/toc/2041-1723The molecular pathway(s) driving antipsychotics (AP) induced hyperphagia remains unclear. A novel C. elegans system is used here to screen for FDA approved drugs that selectively suppresses this response, unraveling potential molecular mediators influencing AP induced hyperphagia in mouse models.Anabel Perez-GomezMaria CarreteroNatalie WeberVeronika PeterkaAlan ToViktoriya TitovaGregory SolisOlivia OsbornMichael PetrascheckNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anabel Perez-Gomez Maria Carretero Natalie Weber Veronika Peterka Alan To Viktoriya Titova Gregory Solis Olivia Osborn Michael Petrascheck A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia
description	The molecular pathway(s) driving antipsychotics (AP) induced hyperphagia remains unclear. A novel C. elegans system is used here to screen for FDA approved drugs that selectively suppresses this response, unraveling potential molecular mediators influencing AP induced hyperphagia in mouse models.
format	article
author	Anabel Perez-Gomez Maria Carretero Natalie Weber Veronika Peterka Alan To Viktoriya Titova Gregory Solis Olivia Osborn Michael Petrascheck
author_facet	Anabel Perez-Gomez Maria Carretero Natalie Weber Veronika Peterka Alan To Viktoriya Titova Gregory Solis Olivia Osborn Michael Petrascheck
author_sort	Anabel Perez-Gomez
title	A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia
title_short	A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia
title_full	A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia
title_fullStr	A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia
title_full_unstemmed	A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia
title_sort	phenotypic caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f0bb27eb5a4746e6b17de6526ad7e3a7
work_keys_str_mv	AT anabelperezgomez aphenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT mariacarretero aphenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT natalieweber aphenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT veronikapeterka aphenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT alanto aphenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT viktoriyatitova aphenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT gregorysolis aphenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT oliviaosborn aphenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT michaelpetrascheck aphenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT anabelperezgomez phenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT mariacarretero phenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT natalieweber phenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT veronikapeterka phenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT alanto phenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT viktoriyatitova phenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT gregorysolis phenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT oliviaosborn phenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia AT michaelpetrascheck phenotypiccaenorhabditiselegansscreenidentifiesaselectivesuppressorofantipsychoticinducedhyperphagia
_version_	1718380466979995648

A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia

Ejemplares similares