Validation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis

Cognitive fatigability is an objective performance decrement that occurs over time during a task requiring sustained cognitive effort. Although cognitive fatigability is a common and debilitating symptom in multiple sclerosis (MS), there is currently no standard for its quantification. The objective...

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Autores principales:	Caitlin S. Walker, Jason A. Berard, Lisa A. S. Walker
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	PASAT cognitive fatigability fatigue normative data regression-based norms discrete norms Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f0bb4d732d1e4a5bb30383538ffcbb6d
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spelling	oai:doaj.org-article:f0bb4d732d1e4a5bb30383538ffcbb6d2021-11-15T06:23:04ZValidation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis1662-453X10.3389/fnins.2021.730817https://doaj.org/article/f0bb4d732d1e4a5bb30383538ffcbb6d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.730817/fullhttps://doaj.org/toc/1662-453XCognitive fatigability is an objective performance decrement that occurs over time during a task requiring sustained cognitive effort. Although cognitive fatigability is a common and debilitating symptom in multiple sclerosis (MS), there is currently no standard for its quantification. The objective of this study was to validate the Paced Auditory Serial Addition Test (PASAT) discrete and regression-based normative data for quantifying performance and cognitive fatigability in an Ontario-based sample of individuals with MS. Healthy controls and individuals with MS completed the 3″ and 2″ versions of the PASAT. PASAT performance was measured with total correct, dyad, and percent dyad scores. Cognitive fatigability scores were calculated by comparing performance on the first half (or third) of the task to the last half (or third). The results revealed that the 3″ PASAT was sufficient to detect impaired performance and cognitive fatigability in individuals with MS given the increased difficulty of the 2″ version. In addition, using halves or thirds for calculating cognitive fatigability scores were equally effective methods for detecting impairment. Finally, both the discrete and regression-based norms classified a similar proportion of individuals with MS as having impaired performance and cognitive fatigability. These newly validated discrete and regression-based PASAT norms provide a new tool for clinicians to document statistically significant cognitive fatigability in their patients.Caitlin S. WalkerJason A. BerardLisa A. S. WalkerLisa A. S. WalkerLisa A. S. WalkerFrontiers Media S.A.articlePASATcognitive fatigabilityfatiguenormative dataregression-based normsdiscrete normsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PASAT cognitive fatigability fatigue normative data regression-based norms discrete norms Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	PASAT cognitive fatigability fatigue normative data regression-based norms discrete norms Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Caitlin S. Walker Jason A. Berard Lisa A. S. Walker Lisa A. S. Walker Lisa A. S. Walker Validation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis
description	Cognitive fatigability is an objective performance decrement that occurs over time during a task requiring sustained cognitive effort. Although cognitive fatigability is a common and debilitating symptom in multiple sclerosis (MS), there is currently no standard for its quantification. The objective of this study was to validate the Paced Auditory Serial Addition Test (PASAT) discrete and regression-based normative data for quantifying performance and cognitive fatigability in an Ontario-based sample of individuals with MS. Healthy controls and individuals with MS completed the 3″ and 2″ versions of the PASAT. PASAT performance was measured with total correct, dyad, and percent dyad scores. Cognitive fatigability scores were calculated by comparing performance on the first half (or third) of the task to the last half (or third). The results revealed that the 3″ PASAT was sufficient to detect impaired performance and cognitive fatigability in individuals with MS given the increased difficulty of the 2″ version. In addition, using halves or thirds for calculating cognitive fatigability scores were equally effective methods for detecting impairment. Finally, both the discrete and regression-based norms classified a similar proportion of individuals with MS as having impaired performance and cognitive fatigability. These newly validated discrete and regression-based PASAT norms provide a new tool for clinicians to document statistically significant cognitive fatigability in their patients.
format	article
author	Caitlin S. Walker Jason A. Berard Lisa A. S. Walker Lisa A. S. Walker Lisa A. S. Walker
author_facet	Caitlin S. Walker Jason A. Berard Lisa A. S. Walker Lisa A. S. Walker Lisa A. S. Walker
author_sort	Caitlin S. Walker
title	Validation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis
title_short	Validation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis
title_full	Validation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis
title_fullStr	Validation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis
title_full_unstemmed	Validation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis
title_sort	validation of discrete and regression-based performance and cognitive fatigability normative data for the paced auditory serial addition test in multiple sclerosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f0bb4d732d1e4a5bb30383538ffcbb6d
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Validation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis

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