Early identification of patient at risk of acute severe pancreatitis with systemic inflammatory response

Introduction and Objective: Clinically, the Systemic Inflammatory Response Syndrome (SIRS) is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leukocyte count. The relationship between SIRS symptoms at the time of presentation and severi...

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Autores principales:	U Laudari, TP Parajuli, A Parajuli, SR Rupakheti, MR Joshi
Formato:	article
Lenguaje:	EN
Publicado:	Society of Surgeons of Nepal 2016
Materias:	Acute Pancreatitis SIRS severe pancreatitis Surgery RD1-811
Acceso en línea:	https://doaj.org/article/f0c121f1d9f9406ab047b2a29baf60fd
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spelling	oai:doaj.org-article:f0c121f1d9f9406ab047b2a29baf60fd2021-12-05T19:16:40ZEarly identification of patient at risk of acute severe pancreatitis with systemic inflammatory response10.3126/jssn.v18i3.152881815-39842392-4772https://doaj.org/article/f0c121f1d9f9406ab047b2a29baf60fd2016-07-01T00:00:00Zhttps://www.nepjol.info/index.php/JSSN/article/view/15288https://doaj.org/toc/1815-3984https://doaj.org/toc/2392-4772 Introduction and Objective: Clinically, the Systemic Inflammatory Response Syndrome (SIRS) is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leukocyte count. The relationship between SIRS symptoms at the time of presentation and severity of pancreatitis is yet to be determined though progression of SIRS in subsequent days has been already correlated. The aim our study was to determine the severity of pancreatitis with SIRS score at the time of admission. Materials and Methods: We conducted prospective cohort study of consecutive patient admitted to emergency of KMCTH, with diagnosis of Acute Pancreatitis (AP) from December 2014 to January 2016. Clinical, biochemical and imaging data from the patients were collected to diagnose pancreatitis. Acute Pancreatitis was diagnosed as per Revised Atlanta Classification 2012. SIRS was evaluated at the time of admission and was correlated with Modified Marshall scoring system for organ dysfunction and sensitivity, specificity and predictive value of SIRS score at admission for organ failure was calculated. Results: Among 41 patients admitted with diagnosis of Acute pancreatitis irrespective of cause the sensitivity of SIRS score at admission in predicting Severe pancreatitis was 28 %, specificity was 80%, Positive predictive value was 60 % and NPV was 51 %, with P value of 0.52 and odds ratio of 1.6 ( CI- 0.376-6.808). Conclusion: This study showed that SIRS score at admission is not sensitive in predicting severe pancreatitis however it is specific for severe pancreatitis. U LaudariTP ParajuliA ParajuliSR RupakhetiMR JoshiSociety of Surgeons of NepalarticleAcute PancreatitisSIRSsevere pancreatitisSurgeryRD1-811ENJournal of Society of Surgeons of Nepal, Vol 18, Iss 3 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acute Pancreatitis SIRS severe pancreatitis Surgery RD1-811
spellingShingle	Acute Pancreatitis SIRS severe pancreatitis Surgery RD1-811 U Laudari TP Parajuli A Parajuli SR Rupakheti MR Joshi Early identification of patient at risk of acute severe pancreatitis with systemic inflammatory response
description	Introduction and Objective: Clinically, the Systemic Inflammatory Response Syndrome (SIRS) is identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leukocyte count. The relationship between SIRS symptoms at the time of presentation and severity of pancreatitis is yet to be determined though progression of SIRS in subsequent days has been already correlated. The aim our study was to determine the severity of pancreatitis with SIRS score at the time of admission. Materials and Methods: We conducted prospective cohort study of consecutive patient admitted to emergency of KMCTH, with diagnosis of Acute Pancreatitis (AP) from December 2014 to January 2016. Clinical, biochemical and imaging data from the patients were collected to diagnose pancreatitis. Acute Pancreatitis was diagnosed as per Revised Atlanta Classification 2012. SIRS was evaluated at the time of admission and was correlated with Modified Marshall scoring system for organ dysfunction and sensitivity, specificity and predictive value of SIRS score at admission for organ failure was calculated. Results: Among 41 patients admitted with diagnosis of Acute pancreatitis irrespective of cause the sensitivity of SIRS score at admission in predicting Severe pancreatitis was 28 %, specificity was 80%, Positive predictive value was 60 % and NPV was 51 %, with P value of 0.52 and odds ratio of 1.6 ( CI- 0.376-6.808). Conclusion: This study showed that SIRS score at admission is not sensitive in predicting severe pancreatitis however it is specific for severe pancreatitis.
format	article
author	U Laudari TP Parajuli A Parajuli SR Rupakheti MR Joshi
author_facet	U Laudari TP Parajuli A Parajuli SR Rupakheti MR Joshi
author_sort	U Laudari
title	Early identification of patient at risk of acute severe pancreatitis with systemic inflammatory response
title_short	Early identification of patient at risk of acute severe pancreatitis with systemic inflammatory response
title_full	Early identification of patient at risk of acute severe pancreatitis with systemic inflammatory response
title_fullStr	Early identification of patient at risk of acute severe pancreatitis with systemic inflammatory response
title_full_unstemmed	Early identification of patient at risk of acute severe pancreatitis with systemic inflammatory response
title_sort	early identification of patient at risk of acute severe pancreatitis with systemic inflammatory response
publisher	Society of Surgeons of Nepal
publishDate	2016
url	https://doaj.org/article/f0c121f1d9f9406ab047b2a29baf60fd
work_keys_str_mv	AT ulaudari earlyidentificationofpatientatriskofacuteseverepancreatitiswithsystemicinflammatoryresponse AT tpparajuli earlyidentificationofpatientatriskofacuteseverepancreatitiswithsystemicinflammatoryresponse AT aparajuli earlyidentificationofpatientatriskofacuteseverepancreatitiswithsystemicinflammatoryresponse AT srrupakheti earlyidentificationofpatientatriskofacuteseverepancreatitiswithsystemicinflammatoryresponse AT mrjoshi earlyidentificationofpatientatriskofacuteseverepancreatitiswithsystemicinflammatoryresponse
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Early identification of patient at risk of acute severe pancreatitis with systemic inflammatory response

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